human immunodeficiency virus

Advanced Drug Delivery to the Lymphatic System: Lipid-Based Nanoformulations.

Advanced drug delivery to the lymphatic system: lipid-based nanoformulations.

Int J Nanomedicine. 2013; 8: 2733-44
Khan AA, Mudassir J, Mohtar N, Darwis Y

The delivery of drugs and bioactive compounds via the lymphatic system is complex and dependent on… Continue reading

Chemotherapy for Cholangiocarcinoma: An Update.

Chemotherapy for cholangiocarcinoma: An update.

World J Gastrointest Oncol. 2013 Jul 15; 5(7): 171-6
Ramírez-Merino N, Aix SP, Cortés-Funes H

Cholangiocarcinomas (bile duct cancers) are a heterogeneous group of malignancies arising from the epithelial cells of the intrahepatic, perihilar… Continue reading

Psychoeducation Improves Hepatitis C Virus Treatment During Opioid Substitution Therapy: A Controlled, Prospective Multicenter Trial.

Psychoeducation improves hepatitis C virus treatment during opioid substitution therapy: a controlled, prospective multicenter trial.

Clin Infect Dis. 2013 Aug; 57 Suppl 2: S97-S104
Reimer J, Schmidt CS, Schulte B, Gansefort D, Gölz J, Gerken G, Scherbaum N, Verthein… Continue reading

Significant Impact of the MTHFR Polymorphisms and Haplotypes on Male Infertility Risk.

Significant Impact of the MTHFR Polymorphisms and Haplotypes on Male Infertility Risk.

PLoS One. 2013; 8(7): e69180
Gupta N, Sarkar S, David A, Gangwar PK, Gupta R, Khanna G, Sankhwar SN, Khanna A, Rajender S

Methylenetetrahydrofolate reductase (MTHFR) converts 5,10-methylene tetrahydrofolate to 5-methyl tetrahydrofolate and affects the activity of cellular cycles participating in nucleotide synthesis, DNA repair, genome stability, maintenance of methyl pool, and gene regulation. Genetically compromised MTHFR activity has been suggested to affect male fertility. The objective of the present study was to find the impact on infertility risk of c.203G>A, c.1298A>C, and c.1793G>A polymorphisms in the MTHFR gene.PCR-RFLP and DNA sequencing were used to genotype the common SNPs in the MTHFR gene in 630 infertile and 250 fertile males. Chi-square test was applied for statistical comparison of genotype data. Linkage disequilibrium between the SNPs and the frequency of common haplotypes were assessed using Haploview software. Biochemical levels of total homocysteine (tHcy) and folic acid were measured. Meta-analysis on c.1298A>C polymorphism was performed using data from ten studies, comprising 2734 cases and 2737 controls.c.203G>A and c.1298A>C were found to be unrelated to infertility risk. c.1793G>A was protective against infertility (P?=?0.0008). c.677C>T and c.1793G>A were in significant LD (D’?=?0.9). Folic acid and tHcy level did not correlate with male infertility. Pooled estimate on c.1298A>C data from all published studies including our data showed no association of this polymorphism with male infertility (Odds ratio?=?1.035, P?=?0.56), azoospermia (Odds ratio?=?0.97, P?=?0.74), or oligoasthenoteratozoospermia (Odds ratio?=?0.92, p?=?0.29). Eight haplotypes with more than 1% frequency were detected, of which CCGA was protective against infertility (p?=?0.02), but the significance of the latter was not seen after applying Bonferroni correction.Among MTHFR polymorphisms, c.203G>A and c.1298A>C do not affect infertility risk and c.1793G>A is protective against… Continue reading

Autophagy in Breast Cancer and Its Implications for Therapy.

Autophagy in breast cancer and its implications for therapy.

Am J Cancer Res. 2013; 3(3): 251-65
Jain K, Paranandi KS, Sridharan S, Basu A

Autophagy is an evolutionarily conserved process of cellular self-digestion that serves as a mechanism to… Continue reading

Discouraging Adverse Drug Reactions Reporting Culture: Just a Tip of the ‘Gullible Prescribing’.

Discouraging adverse drug reactions reporting culture: Just a tip of the ‘Gullible Prescribing’.

Perspect Clin Res. 2013 Apr; 4(2): 153-4
Mohammed I

HubMed – drug

 

Adverse drug reactions to antiretroviral therapy: Results from spontaneous reporting system in Nigeria.… Continue reading

Paget Disease of Bone: Diagnosis and Drug Therapy.

Paget disease of bone: Diagnosis and drug therapy.

Cleve Clin J Med. 2013 Jul; 80(7): 452-462
Seton M

Paget disease of bone is a focal disorder of aging bone that may be asymptomatic or may present with pain, bowing… Continue reading

Qualitative Study of the Quality of Sleep in Marginalized Individuals Living With HIV.

Qualitative study of the quality of sleep in marginalized individuals living with HIV.

Patient Prefer Adherence. 2013; 7: 499-507
Saberi P, Comfort M, Sheon N, Johnson MO

Sleep disturbances have been reported to be higher in human immunodeficiency virus… Continue reading

The Effects of Extended Release Niacin on Lipoprotein Sub-Particle Concentrations in HIV-Infected Patients.

The Effects of Extended Release Niacin on Lipoprotein Sub-Particle Concentrations in HIV-Infected Patients.

Hawaii J Med Public Health. 2013 Apr; 72(4): 123-7
Lin C, Grandinetti A, Shikuma C, Souza S, Parikh N, Nakamoto B, Kallianpur KJ, Chow D

With… Continue reading

Global Drug Policy Fuels Hepatitis C Epidemic, Report Warns.

Global drug policy fuels hepatitis C epidemic, report warns.

Lancet. 2013 Jun 1; 381(9881): 1891
Clark F

HubMed – drug

 

Reversible acute kidney injury requiring haemodialysis five days after starting dronedarone in a stable 71-year-old man at risk… Continue reading