human immunodeficiency virus

Pharmacotherapies for COPD.

Published May 25, 2013

Pharmacotherapies for COPD.

Clin Med Insights Circ Respir Pulm Med. 2013; 7: 17-34
Ejiofor S, Turner AM

This review article summarizes the main treatments for chronic obstructive pulmonary disease, their mechanisms, and the key evidence from trials supporting their… Continue reading →

Adherence to Antiretroviral Therapy Among People Living With HIV.

Published April 30, 2013

Adherence to Antiretroviral Therapy Among People Living with HIV.

N Am J Med Sci. 2013 Mar; 5(3): 220-3
Achappa B, Madi D, Bhaskaran U, Ramapuram JT, Rao S, Mahalingam S

Acquired immune deficiency syndrome (AIDS) is now considered as a manageable chronic illness. There has been a dramatic reduction in human immunodeficiency virus (HIV) related morbidity and mortality due to antiretroviral therapy. A high level of adherence (>95%) is required for antiretroviral therapy to be effective.… Continue reading →

The Role of Etravirine in the Management of Treatment-Experienced Pediatric Patients With HIV.

Published April 24, 2013

The role of etravirine in the management of treatment-experienced pediatric patients with HIV.

HIV AIDS (Auckl). 2013; 5: 67-73
Osterholzer D

Pediatric patients infected with human immunodeficiency virus (HIV) are now living longer, healthier lives due to the advent… Continue reading →

Analysis of Novel Melphalan Hydrolysis Products Formed Under Isolated Lung Perfusion Conditions Using Liquid Chromatography/tandem Mass Spectrometry.

Published March 16, 2013

Analysis of novel melphalan hydrolysis products formed under isolated lung perfusion conditions using liquid chromatography/tandem mass spectrometry.

Rapid Commun Mass Spectrom. 2013 Apr 15; 27(7): 835-841
Boschmans J, de Bruijn E, Van Schil P, Lemière F

RATIONALE: Melphalan is a widely used cytotoxic agent in cancer treatments. This phenylalanine analog has been shown an effective drug in the treatment of breast cancer, multiple myeloma and melanoma of the extremities. A good knowledge of the drug’s degradation and metabolism are crucial for understanding its activity during cancer treatments. METHODS: The formation of hydrolysis products of melphalan is studied using ultra-performance liquid chromatography (UPLC) tandem mass spectrometry (MS/MS). Aqueous melphalan solutions were incubated at elevated temperatures and analyzed by UPLC/MS/MS. Two previously described hydrolysis products, mono- and dihydroxymelphalan (MOH and DOH), were formed in vitro and could be characterized during MS/MS and high-resolution experiments. RESULTS: Novel compounds with m/z values >500?Da were discovered.… Continue reading →

Closing the Door to Human Immunodeficiency Virus.

Published March 13, 2013

Closing the door to human immunodeficiency virus.

Protein Cell. 2013 Feb; 4(2): 86-102
Kang Y, Guo J, Chen Z

The pandemic of human immunodeficiency virus type one (HIV-1), the major etiologic agent of acquired immunodeficiency disease (AIDS), has led… Continue reading →

Use of Whole Genome Sequencing to Determine the Microevolution of Mycobacterium Tuberculosis During an Outbreak.

Published March 9, 2013

Use of Whole Genome Sequencing to Determine the Microevolution of Mycobacterium tuberculosis during an Outbreak.

PLoS One. 2013; 8(3): e58235
Kato-Maeda M, Ho C, Passarelli B, Banaei N, Grinsdale J, Flores L, Anderson J, Murray M, Rose G, Kawamura… Continue reading →

Gene Expression and Thiopurine Metabolite Profiling in Inflammatory Bowel Disease – Novel Clues to Drug Targets and Disease Mechanisms?

Published February 27, 2013

Gene expression and thiopurine metabolite profiling in inflammatory bowel disease – novel clues to drug targets and disease mechanisms?

PLoS One. 2013; 8(2): e56989
Haglund S, Almer S, Peterson C, Söderman J

Thiopurines are effective to induce and maintain remission in inflammatory bowel disease (IBD). The methyl thioinosine monophosphate (meTIMP)/6-thioguanine nucleotide (6-TGN) concentration ratio has been associated with drug efficacy. Here we explored the molecular basis of differences in metabolite profiles and in relation to disease activity.Transcriptional profiles in blood samples from an exploratory IBD-patient cohort (n?=?21) with a normal thiopurine S-methyltransferase phenotype and meTIMP/6-TGN ratios >20, 10.0-14.0 and ?4, respectively, were assessed… Continue reading →

Posttraumatic Stress Disorder, Depression, and HIV Risk Behavior Among Ohio Army National Guard Soldiers.

Published February 19, 2013

Posttraumatic Stress Disorder, Depression, and HIV Risk Behavior Among Ohio Army National Guard Soldiers.

Filed under: Depression Treatment

J Trauma Stress. 2013 Feb; 26(1): 64-70
Marshall BD, Prescott MR, Liberzon I, Tamburrino MB, Calabrese JR, Galea S

We examined… Continue reading →

Drug and Alcohol Rehabilitation: Combining Oxymatrine or Matrine With Lamivudine Increased Its Antireplication Effect Against the Hepatitis B Virus in Vitro.

Published February 13, 2013

Combining Oxymatrine or Matrine with Lamivudine Increased Its Antireplication Effect against the Hepatitis B Virus In Vitro.

Filed under: Drug and Alcohol Rehabilitation

Evid Based Complement Alternat Med. 2013; 2013: 186573
Ma ZJ, Li Q, Wang JB, Zhao YL,… Continue reading →

Drug and Alcohol Rehabilitation: Cardiovascular Toxicity of Citrus Aurantium in Exercised Rats.

Published February 12, 2013

Cardiovascular Toxicity of Citrus aurantium in Exercised Rats.