Postradiation Osteosarcoma in an Older Prostate Cancer Survivor: Case Study and Literature Review With Emphasis on Geriatric Principles.
Postradiation osteosarcoma in an older prostate cancer survivor: case study and literature review with emphasis on geriatric principles.
Case Rep Oncol. 2013 May; 6(2): 250-5
Gumber D, Rodin M, Wildes TM
The aging population and the increasing number of… Continue reading
Do Children Have the Same Vulnerability to Metabolic Drug–Drug Interactions as Adults? a Critical Analysis of the Literature.
Do children have the same vulnerability to metabolic drug–drug interactions as adults? A critical analysis of the literature.
J Clin Pharmacol. 2013 May; 53(5): 559-66
Salem F, Rostami-Hodjegan A, Johnson TN
Many drug–drug interactions (DDIs) in the pediatric population are managed based on data generated in adults. However, due to developmental changes in elimination pathways from birth to adolesence, and variable weight?adjusted dose of interacting drugs, the assumption of DDIs being similar in adults and pediatrics might not be correct. This study compares the magnitude of reported DDIs in pediatric and adult populations. A systematic literature review was undertaken to identify reports of DDIs in pediatric subjects. A total of 145 reports of DDIs were identified over the age range of birth to 20 years. The magnitude of DDIs for 24 drug pairs from 31 different pediatric studies could be assessed and compared with those in adults where corresponding data existed. The magnitude of the DDI, as measured by a relevant parameter (e.g., AUC, CL) in the presence and absence of inhibitor,were higher (>1.25?fold), similar (0.8? to 1.25?fold) or lower (… Continue reading
Systematic Review of Prenatal Cocaine Exposure and Adolescent Development.
Systematic Review of Prenatal Cocaine Exposure and Adolescent Development.
Pediatrics. 2013 May 27;
Buckingham-Howes S, Berger SS, Scaletti LA, Black MM
BACKGROUND AND OBJECTIVE:Previous research found that prenatal cocaine exposure (PCE) may increase children’s vulnerability to behavior and cognition… Continue reading
Life-Review Interventions as Psychotherapeutic Techniques in Psychotraumatology.
Life-review interventions as psychotherapeutic techniques in psychotraumatology.
Eur J Psychotraumatol. 2013; 4:
Maercker A, Bachem R
Life-review interventions (LRI) are psychotherapeutic techniques originally derived from gerontology, which can be distinguished from other biographical and reminiscing techniques. They have been… Continue reading
Challenges in the Optimisation of Post-Operative Pain Management With Opioids in Obese Patients: A Literature Review.
Challenges in the Optimisation of Post-operative Pain Management with Opioids in Obese Patients: a Literature Review.
Obes Surg. 2013 May 23;
Lloret-Linares C, Lopes A, Declèves X, Serrie A, Mouly S, Bergmann JF, Perrot S
An increasing number of… Continue reading