Statin a Day Keeps Cancer at Bay.
Statin a day keeps cancer at bay.
World J Clin Oncol. 2013 May 10; 4(2): 43-6
Singh S, Singh PP
In addition to cholesterol reduction, statins, currently the most commonly prescribed drug in the world, have been shown to… Continue reading
Evaluation of a New Nonnvasive Device in Determining Hemoglobin Levels in Emergency Department Patients.
Evaluation of a New Nonnvasive Device in Determining Hemoglobin Levels in Emergency Department Patients.
West J Emerg Med. 2013 May; 14(3): 283-286
Knutson T, Della-Giustina D, Tomich E, Wills B, Luerssen E, Reynolds P
Introduction: The Masimo Radical-7 Pulse CO-Oximeter is a medical device recently approved by the US Food and Drug Administration that performs noninvasive oximetry and estimated venous or arterial hemoglobin measurements. A portable, noninvasive device that rapidly measures hemoglobin concentration could be useful in both austere and modern hospital settings. The objective of this study is to determine the degree of variation between the device’s estimated hemoglobin measurement and the actual venous hemoglobin concentration in undifferentiated emergency department (ED) patients. Methods: We conducted a prospective, observational, cross-sectional study of adult patients presenting to the ED. The subjects consisted of a convenience sample of adult ED patients who required a complete blood count as part of their care in the ED. A simultaneous probe hemoglobin was obtained and recorded. Results: Bias between probe and laboratory hemoglobin measurements was -0.5 (95% confidence interval, – 0.8 to -0.1) but this was not statistically significant from 0 (t 0.05,124 = 0.20, P > 0.5). The limits of agreement… Continue reading
Tumor Burden Talks in Cancer Treatment With PEGylated Liposomal Drugs.
Tumor Burden Talks in Cancer Treatment with PEGylated Liposomal Drugs.
PLoS One. 2013; 8(5): e63078
Lin YY, Kao HW, Li JJ, Hwang JJ, Tseng YL, Lin WJ, Lin MH, Ting G, Wang HE
PEGylated liposomes are important drug carriers that can passively target tumor by enhanced permeability and retention (EPR) effect in neoplasm lesions. This study demonstrated that tumor burden determines the tumor uptake, and also the tumor response, in cancer treatment with PEGylated liposomal drugs in a C26/tk-luc colon carcinoma-bearing mouse model.Empty PEGylated liposomes (NanoX) and those encapsulated with VNB (NanoVNB) were labeled with In-111 to obtain InNanoX and InVNBL in high labeling yield and radiochemical purity (all >90%). BALB/c mice bearing either small… Continue reading
Interplay Between Pro-Inflammatory Cytokines and Growth Factors in Depressive Illnesses.
Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses.
Front Cell Neurosci. 2013; 7: 68
Audet MC, Anisman H
The development of depressive disorders had long been attributed to monoamine variations, and pharmacological treatment strategies likewise focused on… Continue reading
Fifty-Two-Week Continuous Abstinence Rates of Smokers Being Treated With Varenicline Versus Nicotine Replacement Therapy.
Fifty-two-week continuous abstinence rates of smokers being treated with varenicline versus nicotine replacement therapy.
Addiction. 2013 May 13;
Kralikova E, Kmetova A, Stepankova L, Zvolska K, Davis R, West R
BACKGROUND AND AIMS: Cross-study comparisons of effect sizes suggest… Continue reading
Factors Associated With Sexuality Following Traumatic Brain Injury.
Factors associated with sexuality following traumatic brain injury.
J Head Trauma Rehabil. 2013 May-Jun; 28(3): 195-201
Ponsford JL, Downing MG, Stolwyk R
: Previous research has demonstrated that sexuality is compromised following traumatic brain injury (TBI).: The aim of… Continue reading
Fusion of Dioxygenase and Lignin-Binding Domains in a Novel Secreted Enzyme From Cellulolytic Streptomyces Sp. SirexAA-E.
Fusion of dioxygenase and lignin-binding domains in a novel secreted enzyme from cellulolytic Streptomyces sp. SirexAA-E.
J Biol Chem. 2013 May 7;
Bianchetti CM, Harmann CH, Takasuka TE, Hura GL, Dyer K, Fox BG
Streptomyces sp. SirexAA-E is a… Continue reading