clinical studies

Rapid Countermeasure Discovery Against Francisella Tularensis Based on a Metabolic Network Reconstruction.

Rapid Countermeasure Discovery against Francisella tularensis Based on a Metabolic Network Reconstruction.

PLoS One. 2013; 8(5): e63369
Chaudhury S, Abdulhameed MD, Singh N, Tawa GJ, D’haeseleer PM, Zemla AT, Navid A, Zhou CE, Franklin MC, Cheung J, Rudolph MJ,… Continue reading

Rehabilitation in Bilingual Aphasia: Evidence for Within- and Between-Language Generalization.

Rehabilitation in bilingual aphasia: evidence for within- and between-language generalization.

Am J Speech Lang Pathol. 2013 May; 22(2): S298-309
Kiran S, Sandberg C, Gray T, Ascenso E, Kester E

The goal of this study was to examine if there was a principled way to understand the nature of rehabilitation in bilingual aphasia such that patterns of acquisition and generalization are predictable and logical.Seventeen Spanish-English bilingual individuals with aphasia participated in the experiment. For each participant, three sets of stimuli were developed for each language: (a) English Set 1, (b) English Set 2 (semantically related to each item in English Set 1), (c) English Set 3 (unrelated control items), (d) Spanish Set 1 (translations of English Set 1), (e) Spanish Set 2 (translations of English Set 2; semantically related to each item in Spanish Set 1), and (f) Spanish Set 3 (translations of English Set 3; unrelated control items). A single-subject experimental multiple baseline design across participants was implemented. Treatment was conducted in 1 language, but generalization to within- and between-language untrained items was examined.Treatment for naming on Set 1 items resulted in significant improvement (i.e., effect size >4.0) on the trained items in 14/17 participants. Of the… Continue reading

Propofol for Procedural Sedation in the Emergency Department: A Qualitative Systematic Review (June).

Propofol for Procedural Sedation in the Emergency Department: A Qualitative Systematic Review (June).

Ann Pharmacother. 2013 May 21;
Black E, Campbell SG, Magee K, Zed PJ

OBJECTIVE:To evaluate the efficacy and safety of propofol compared to other agents for… Continue reading

BDNF Over-Expression in the Ventral Tegmental Area Prolongs Social Defeat Stress-Induced Cross-Sensitization to Amphetamine and Increases ?FosB Expression in Mesocorticolimbic Regions of Rats.

BDNF Over-Expression in the Ventral Tegmental Area Prolongs Social Defeat Stress-induced Cross-Sensitization to Amphetamine and Increases ?FosB Expression in Mesocorticolimbic Regions of Rats.

Neuropsychopharmacology. 2013 May 21;
Wang J, Fanous S, Terwilliger EF, Bass CE, Hammer RP, Nikulina EM… Continue reading

The Metabolism of Lymphomas.

The metabolism of lymphomas.

Curr Opin Hematol. 2013 May 13;
Calvo-Vidal MN, Cerchietti L

PURPOSE OF REVIEW: Cellular to animal to human studies are shedding light on metabolic pathways that contribute to sustaining lymphomagenesis. Old players with new metabolic… Continue reading

[Laquinimod Is an Oral Drug With a Marked Neuroprotective Effect for Pathogenetic Treatment of Multiple Sclerosis(review)].

[Laquinimod is an oral drug with a marked neuroprotective effect for pathogenetic treatment of multiple sclerosis(review)].

Zh Nevrol Psikhiatr Im S S Korsakova. 2013; 113(2 Pt 2): 93-9

New oral therapies of MS cause great attention. This review includes… Continue reading

Effect of Pilot Hole on Biomechanical and in Vivo Pedicle Screw-Bone Interface.

Effect of pilot hole on biomechanical and in vivo pedicle screw-bone interface.

Eur Spine J. 2013 May 8;
Silva P, Rosa RC, Shimano AC, Defino HL

PURPOSE: To experimentally study the influence of pilot hole diameter (smaller than or… Continue reading

Health Problems Among the Elderly: A Cross-Sectional Study.

Health problems among the elderly: a cross-sectional study.

Ann Med Health Sci Res. 2013 Jan; 3(1): 19-25
Thakur R, Banerjee A, Nikumb V

Estimates of health problems of the elderly in developing countries are required from time to time… Continue reading

Can MDMA Play a Role in the Treatment of Substance Abuse?

Can MDMA Play a Role in the Treatment of Substance Abuse?

Curr Drug Abuse Rev. 2013 Apr 29;
Jerome L, Shira Schuster MA, Yazar-Klosinski BB

A wider array of treatments are needed for people with substance abuse disorders. Some… Continue reading

Cannabinoid and Opioid Interactions: Implications for Opiate Dependence and Withdrawal.

Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal.

Neuroscience. 2013 Apr 24;
Scavone JL, Sterling RC, Van Bockstaele EJ

Withdrawal from opiates, such as heroin or oral narcotics, is characterized by a host of aversive physical and… Continue reading