breast cancer

Post Laryngectomy Speech Rehabilitation Outcome in Elderly Patients.

Post laryngectomy speech rehabilitation outcome in elderly patients.

Eur Arch Otorhinolaryngol. 2013 Mar 22;
Cocuzza S, Bonfiglio M, Grillo C, Maiolino L, Malaguarnera M, Martines F, Serra A

The aim of our work has been to evaluate the different options of tracheoesophageal voice rehabilitation in over 70-year-old patients, who had undergone laryngectomy, assessing advantages and drawbacks of this method of vocal recovery. A retrospective study has been carried out. This has included 40 subjects, all aged more than 70 years old, who have been referred to tracheoesophageal voice rehabilitation. It has been realized a phonatory fistula between trachea and esophagus with prosthesis positioning by means of a primary puncture in 18 cases and it has been realized a secondary puncture in 22 cases. The results gathered in these patients were compared with data obtained from a group made of 39 patients, less than 70 years of age that therefore represented our control group. In primary tracheoesophageal puncture (TEP), the short-term success was 67 %, while in the 22 cases who underwent secondary TEP, the short-term success was 64 %. After 2 years from TEP, the long-term success was 82.5 %. In the control group, the short-term success was 65 % in primary TEP and 73 % in secondary TEP. After 2 years from TEP, the long-term success was 77 %. The evaluation of the results has shown the absence of a statistically significant difference both as regards complications incidence, during and after surgery (p > 0.9) and as regards overall success ratio of prosthesis implants between the two groups (p > 0.7). The possibilities of tracheoesophageal recovery of elderly patients do… Continue reading

T-Cell Responses in Oiled Guillemots and Swans in a Rehabilitation Setting.

T-cell Responses in Oiled Guillemots and Swans in a Rehabilitation Setting.

Arch Environ Contam Toxicol. 2013 Mar 20;
Troisi GM

Aquatic birds are commonly affected by oil spills. Despite rehabilitation efforts, the majority of rehabilitated common guillemots (Uria aalge)… Continue reading

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Study: Radiation for breast cancer… Continue reading

Analysis of Novel Melphalan Hydrolysis Products Formed Under Isolated Lung Perfusion Conditions Using Liquid Chromatography/tandem Mass Spectrometry.

Analysis of novel melphalan hydrolysis products formed under isolated lung perfusion conditions using liquid chromatography/tandem mass spectrometry.

Rapid Commun Mass Spectrom. 2013 Apr 15; 27(7): 835-841
Boschmans J, de Bruijn E, Van Schil P, Lemière F

RATIONALE: Melphalan is a widely used cytotoxic agent in cancer treatments. This phenylalanine analog has been shown an effective drug in the treatment of breast cancer, multiple myeloma and melanoma of the extremities. A good knowledge of the drug’s degradation and metabolism are crucial for understanding its activity during cancer treatments. METHODS: The formation of hydrolysis products of melphalan is studied using ultra-performance liquid chromatography (UPLC) tandem mass spectrometry (MS/MS). Aqueous melphalan solutions were incubated at elevated temperatures and analyzed by UPLC/MS/MS. Two previously described hydrolysis products, mono- and dihydroxymelphalan (MOH and DOH), were formed in vitro and could be characterized during MS/MS and high-resolution experiments. RESULTS: Novel compounds with m/z values >500?Da were discovered.… Continue reading

Interaction of Neuropeptide Y Genotype and Childhood Emotional Maltreatment on Brain Activity During Emotional Processing.

Interaction of neuropeptide Y genotype and childhood emotional maltreatment on brain activity during emotional processing.

Soc Cogn Affect Neurosci. 2013 Mar 11;
Opmeer EM, Kortekaas R, van Tol MJ, van der Wee NJ, Woudstra S, van Buchem MA, Penninx… Continue reading

Label-Free Recognition of Drug Resistance via Impedimetric Screening of Breast Cancer Cells.

Label-Free Recognition of Drug Resistance via Impedimetric Screening of Breast Cancer Cells.

PLoS One. 2013; 8(3): e57423
Eker B, Meissner R, Bertsch A, Mehta K, Renaud P

We present a novel study on label-free recognition and distinction of drug… Continue reading

Efficient Generation of Stable Bispecific IgG1 by Controlled Fab-Arm Exchange.

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange.

Proc Natl Acad Sci U S A. 2013 Mar 11;
Labrijn AF, Meesters JI, de Goeij BE, van den Bremer ET, Neijssen J, van Kampen MD, Strumane K, Verploegen… Continue reading

Fatty Acid Biosynthesis and Lipogenic Enzyme Activities in Subcutaneous Adipose Tissue of Feedlot Steers Fed Supplementary Palm Oil or Soybean Oil.

Fatty acid biosynthesis and lipogenic enzyme activities in subcutaneous adipose tissue of feedlot steers fed supplementary palm oil or soybean oil.

J Anim Sci. 2013 Mar 5;
Choi SH, Gang GO, Sawyer JE, Johnson BJ, Kim KH, Choi CW,… Continue reading

Incidence and Risk of Mood Disorders in Patients With Breast Cancers in Taiwan: A Nationwide Population-Based Study.

Incidence and risk of mood disorders in patients with breast cancers in Taiwan: a nationwide population-based study.

Psychooncology. 2013 Mar 6;
Hung YP, Liu CJ, Tsai CF, Hung MH, Tzeng CH, Liu CY, Chen TJ

OBJECTIVE: The objective of… Continue reading

[A New Method of Calibration and Positioning in Quantitative Analysis of Multicomponents by Single Marker].

[A new method of calibration and positioning in quantitative analysis of multicomponents by single marker].

Yao Xue Xue Bao. 2012 Dec; 47(12): 1653-9
He B, Yang SY, Zhang Y

This paper aims to establish a new method of calibration… Continue reading