Incidence and Risk of Mood Disorders in Patients With Breast Cancers in Taiwan: A Nationwide Population-Based Study.

Incidence and risk of mood disorders in patients with breast cancers in Taiwan: a nationwide population-based study.

Psychooncology. 2013 Mar 6;
Hung YP, Liu CJ, Tsai CF, Hung MH, Tzeng CH, Liu CY, Chen TJ

OBJECTIVE: The objective of this study is to assess the incidence and risk of mood disorders, including major depression, anxiety, and bipolar disorders, in Taiwanese patients after the diagnosis of breast cancer compared with a matched cohort. METHODS: From January 2000 to December 2005, 26,629 newly diagnosed breast cancer patients were enrolled by the Taiwan National Health Insurance program database. The control cohort was selected randomly from 1,000,000 National Health Insurance beneficiaries from a population of 21,400,826 enrolled throughout Taiwan. Each patient was matched with one subject without breast cancer by age, sex, and presence of comorbidities with the same diagnosis index date. The diagnosis of mood disorders was defined by compatible International Classification of Diseases, 9th revision, clinical modification codes plus the prescription of antidepressants for at least 30?days. RESULTS: The overall incidence rate ratio of mood disorders was 1.33 (95% CI 1.28-1.39, p?HubMed – depression


Cancer-related self-efficacy following a consultation with an oncologist.

Psychooncology. 2013 Mar 6;
Nielsen BK, Mehlsen M, Jensen AB, Zachariae R

OBJECTIVE: When receiving a cancer diagnosis, patients are often faced with psychological distress and loss of control. As a result, their psychological well-being may be influenced by their perceived ability to cope with disease-related and treatment-related challenges. Research indicates that the patient-oncologist relationship may have an impact on patients’ self-efficacy. The aim was to examine predictors of self-efficacy following a consultation in an oncology outpatient clinic and the predictors of change. METHODS: A total of 226 patients (mean age: 61?years, 40% male) attending an oncology outpatient clinic completed questionnaires before and after a consultation including the Hospital Anxiety and Depression Scale, two domain-specific self-efficacy scales measuring coping self-efficacy and decision self-efficacy, the Physician-Patient Relationship Inventory, and the Information Satisfaction Questionnaire. RESULTS: While most patients experienced an increase in self-efficacy following the consultation, some patients experienced lower self-efficacy post-consultation. In the multivariate analysis, depressive symptoms emerged as a relatively strong predictor of both coping self-efficacy and decision self-efficacy, whereas marital status was a significant predictor of coping self-efficacy, and satisfaction with information significantly predicted decision self-efficacy. No significant associations were found between self-efficacy and the patients’ ratings of the physician-patient relationship. CONCLUSION: Depression seems to be a potential risk factor for lower cancer-related self-efficacy, following an oncologist consultation. By identifying patients who exhibit symptoms of depression, health professionals can increase their attention on empowering these patients. Furthermore, our results suggest that patients’ experience of self-efficacy depends on what particular challenges they have to overcome. Copyright © 2013 John Wiley & Sons, Ltd. HubMed – depression


In vivo performance evaluation and establishment of IVIVC for osmotic pump based extended release formulation of Milnacipran HCl.

Biopharm Drug Dispos. 2013 Mar 5;
Parejiya PB, Barot BS, Patel HK, Chorawala MR, Shelat PK, Shukla A

The objective of the present study was to carry out pharmacokinetics evaluation of oral modified release formulation [Aquarius EKX 19102 SRX-2 based osmotic pump (OP)] containing highly soluble Milnacipran HCl (MH) as a model drug. It was also aimed at developing an in vitro-in vivo correlation (IVIVC) models for developed OP. In vivo plasma concentration data were obtained from 6 healthy male New Zealand albino rabbits after administration of immediate-release Milnacipran HCL solution (IRMHSOL) and Milncipran HCl osmotic pump (MHOP). In vitro samples were analysed using in house developed spectrophotometry method and in vivo samples were analyzed using a RP- HPLC method developed by author. A deconvolution based level A model was attempted through a correlation of percent in vivo input obtained through deconvolution and percent in vitro dissolution obtained experimentally. A good correlation between the percentages dissolved vs absorbed (R2 = 0.978) was obtained using level A correlation. Evaluation of the internal predictability of level A correlation was calculated in terms of percent prediction error, which was found to be below 15%. In a nutshell, the success of present study warrants for further studies in patient volunteers to assess the ability of the MHOP in providing an effective therapy of depression. Copyright © 2013 John Wiley & Sons, Ltd. HubMed – depression


Beside the Geriatric Depression Scale: the WHO-Five Well-being Index as a valid screening tool for depression in nursing homes.

Int J Geriatr Psychiatry. 2013 Mar 6;
Allgaier AK, Kramer D, Saravo B, Mergl R, Fejtkova S, Hegerl U

OBJECTIVE: The aim of the study was to compare criterion validities of the WHO-Five Well-being Index (WHO-5) and the Geriatric Depression Scale 15-item version (GDS-15) and 4-item version (GDS-4) as screening instruments for depression in nursing home residents. METHODS: Data from 92 residents aged 65-97?years without severe cognitive impairment (Mini Mental State Examination ?15) were analysed. Criterion validities of the WHO-5, the GDS-15 and the GDS-4 were assessed against diagnoses of major and minor depression provided by the Structured Clinical Interview for DSM-IV. Subanalyses were performed for major and minor depression. Areas under the receiver operating curve (AUCs) as well as sensitivities and specificities at optimal cut-off points were computed. RESULTS: Prevalence of depressive disorder was 28.3%. The AUC value of the WHO-5 (0.90) was similar to that of the GDS-15 (0.82). Sensitivity of the WHO-5 (0.92) at its optimal cut-off of ?12 was significantly higher than that of the GDS-15 (0.69) at its optimal cut-off of ?7. The WHO-5 was equally sensitive for the subgroups of major and minor depression (0.92), whereas the GDS-15 was sensitive only for major depression (0.85), but not for minor depression (0.54). For specificity, there was no significant difference between WHO-5 (0.79) and GDS-15 (0.88), but both instruments outperformed the GDS-4 (0.53). CONCLUSIONS: The WHO-5 demonstrated high sensitivity for major and minor depression. Being shorter than the GDS-15 and superior to the GDS-4, the WHO-5 is a promising screening tool that could help physicians improve low recognition rates of depression in nursing home residents. Copyright © 2013 John Wiley & Sons, Ltd. HubMed – depression