treatment response

The Genetics of Eating Disorders.

...  and twin studies reveal that additive genetic factors account for approximately 40% to 60% of liability to anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Molecular genetics studies have been undertaken to identify alterations in deoxyribonucleic… Continue reading

Depressive Symptoms and All-Cause Mortality in a Nationally Representative Longitudinal Study With Time-Varying Covariates.

...  clinical correlates associated with antidepressant response would reduce symptom severity and morbidity for patients with depression. Twenty-three subjects with major depression were treated with citalopram 20 mg/day in a 6-week open trial and were also simultaneously randomized to either… Continue reading

Chronic Stress Induces Structural Alterations in Splenic Lymphoid Tissue That Are Associated With Changes in Corticosterone Levels in Wistar-Kyoto Rats.

...  the DAS patients were more likely to have severe FLA (14.1% versus 5.6%). Severe FLA remained an independent predictor of DAS in multivariate analysis, with an odds ratio of 2.6 (95% confidence intervals?=?1.2-5.9). Conclusions. The results suggest that FLA… Continue reading

Response to Letter Regarding Article, “Short- and Long-Term Outcomes With Drug-Eluting and Bare-Metal Coronary Stents: A Mixed-Treatment Comparison Analysis of 117,762 Patient-Years of Follow-Up From Randomized Trials”.

...  Fusaro M, Amoroso N, Attubato MJ, Feit F, Slater J, Kumar S, Bhatt DL HubMed – drug   Treatment course with antidepressant therapy in late-life depression. Am J Psychiatry. 2012 Nov 1; 169(11): 1185-93Sheline YI, Disabato BM, Hranilovich J,… Continue reading

Depression, Healthcare Utilization, and Death in Heart Failure: A Community Study.

...  point to potential risk loci of psychotic depression shared with schizoaffective disorder (1q42, 22q11, 19p13), depression, bipolar disorder, and schizophrenia (6p, 8p22, 10p13-12, 10p14, 13q13-14, 13q32, 18p, 22q11-13) and several vulnerability genes possibly contributing to an increased risk of… Continue reading

Repressive Epigenetic Changes at the Mglu2 Promoter in Frontal Cortex of 5-HT2A Knockout Mice.

...  regulated by the 5-HT2A receptor agonist TCB-2, binds less to the mGlu2 promoter in frontal cortex of 5-HT2A-KO as compared to wild-type mice. Furthermore, expression of mGlu2 was increased by viral-mediated gene transfer of Flag-tagged Egr1 in mouse frontal… Continue reading

The Impact of Parental Incarceration on the Physical and Mental Health of Young Adults.

...  in this population. However, studies examining the impact of smoking cessation on changes in affect in smokers with depression are limited and equivocal. METHODS: This study examines affective processes in smokers with depression undergoing a 12-week smoking cessation intervention… Continue reading

[Remission, Response, and Its Prediction in Depressive Inpatients.]

...  as well as other features suggestive of severity of illness. Our results confirm previous findings of associations between SI and panic and (or) phobic symptoms and anxiety, but did not confirm previous findings of an association between SI and… Continue reading

Using the High-Risk Family Design to Identify Biomarkers for Major Depression.

...  promoter polymorphism. We replicated these findings in a novel cohort and reconciled our discrepant findings with other groups using alternate quantification techniques. We also reported higher BP(F) in subjects remitted from a major depressive episode than in controls. From… Continue reading

Macromolecular Prodrugs of Ribavirin Combat Side Effects and Toxicity With No Loss of Activity of the Drug.

...  the signaling pathways regulating the susceptibility of the cells to GCs are only partly revealed. There is still a need to develop clinical tests that can predict the outcome of GC therapy. In this paper, I discuss important parameters… Continue reading