PLoS One

'Love Hormone' Released During Sex and Childbirth Could Cure Anorexia

Published March 14, 2014

'Love hormone' released during sex and childbirth could cure anorexia
Another study, published in the journal PLOS ONE, found that people with the eating disorder – which has been linked to a heightened perception of threat – were less likely… Continue reading →

Crisis Centers Turn to Texting to Help Teens

Published August 22, 2013

Crisis Centers Turn to Texting to Help Teens
A few national help lines are training staff and volunteers in the art of counseling via text message or online chat. The added anonymity of digital communication means people seeking help talk… Continue reading →

Prevalence of Overweight and Obesity in Urban Elementary School Children in Northeastern Romania: Its Relationship With Socioeconomic Status and Associated Dietary and Lifestyle Factors.

Published August 13, 2013

Prevalence of overweight and obesity in urban elementary school children in northeastern romania: its relationship with socioeconomic status and associated dietary and lifestyle factors.

Biomed Res Int. 2013; 2013: 537451
Mocanu V

The purpose of this paper is to… Continue reading →

SAHA Enhances Synaptic Function and Plasticity in Vitro but Has Limited Brain Availability in Vivo and Does Not Impact Cognition.

Published August 9, 2013

SAHA Enhances Synaptic Function and Plasticity In Vitro but Has Limited Brain Availability In Vivo and Does Not Impact Cognition.

PLoS One. 2013; 8(7): e69964
Hanson JE, La H, Plise E, Chen YH, Ding X, Hanania T, Sabath EV,… Continue reading →

Cognitive Reactivity, Implicit Associations, and the Incidence of Depression: A Two-Year Prospective Study.

Published August 9, 2013

Cognitive reactivity, implicit associations, and the incidence of depression: a two-year prospective study.

PLoS One. 2013; 8(7): e70245
Kruijt AW, Antypa N, Booij L, de Jong PJ, Glashouwer K, Penninx BW, Van der Does W

Cognitive reactivity to sad… Continue reading →

Fitness Consequences of Dispersal: Is Leaving Home the Best of a Bad Lot?

Published August 8, 2013

Fitness consequences of dispersal: is leaving home the best of a bad lot?

Ecology. 2013 Jun; 94(6): 1287-95
Waser PM, Nichols KM, Hadfield JD

Using 20 years of demographic and genetic data from four populations of banner-tailed kangaroo rats… Continue reading →

Nothing Will Ever Beat Me, Says Parkinson's Disease Victim Jennifer Bodenhamer

Published August 5, 2013

Nothing will ever beat me, says Parkinson's disease victim Jennifer Bodenhamer
Despite this, doctors put her on Parkinson's drugs. Jennifer returned to caring for … Medication that boosts dopamine levels is used to control the symptoms which, for Jennifer, include… Continue reading →

Differential Impact of Two Risk Communications on Antipsychotic Prescribing to People With Dementia in Scotland: Segmented Regression Time Series Analysis 2001-2011.

Published July 24, 2013

Differential impact of two risk communications on antipsychotic prescribing to people with dementia in Scotland: segmented regression time series analysis 2001-2011.

PLoS One. 2013; 8(7): e68976
Guthrie B, Clark SA, Reynish EL, McCowan C, Morales DR

Regulatory risk communications… Continue reading →

Cortical Shape and Curvedness Analysis of Structural Deficits in Remitting and Non-Remitting Depression.

Published July 24, 2013

Cortical shape and curvedness analysis of structural deficits in remitting and non-remitting depression.

PLoS One. 2013; 8(7): e68625
Liao YL, Wang PS, Lu CF, Hung CI, Li CT, Lin CP, Hsieh JC, Su TP, Wu YT

In morphometric neuroimaging… Continue reading →

Significant Impact of the MTHFR Polymorphisms and Haplotypes on Male Infertility Risk.

Published July 23, 2013

Significant Impact of the MTHFR Polymorphisms and Haplotypes on Male Infertility Risk.

PLoS One. 2013; 8(7): e69180
Gupta N, Sarkar S, David A, Gangwar PK, Gupta R, Khanna G, Sankhwar SN, Khanna A, Rajender S

Methylenetetrahydrofolate reductase (MTHFR) converts 5,10-methylene tetrahydrofolate to 5-methyl tetrahydrofolate and affects the activity of cellular cycles participating in nucleotide synthesis, DNA repair, genome stability, maintenance of methyl pool, and gene regulation. Genetically compromised MTHFR activity has been suggested to affect male fertility. The objective of the present study was to find the impact on infertility risk of c.203G>A, c.1298A>C, and c.1793G>A polymorphisms in the MTHFR gene.PCR-RFLP and DNA sequencing were used to genotype the common SNPs in the MTHFR gene in 630 infertile and 250 fertile males. Chi-square test was applied for statistical comparison of genotype data. Linkage disequilibrium between the SNPs and the frequency of common haplotypes were assessed using Haploview software. Biochemical levels of total homocysteine (tHcy) and folic acid were measured. Meta-analysis on c.1298A>C polymorphism was performed using data from ten studies, comprising 2734 cases and 2737 controls.c.203G>A and c.1298A>C were found to be unrelated to infertility risk. c.1793G>A was protective against infertility (P?=?0.0008). c.677C>T and c.1793G>A were in significant LD (D’?=?0.9). Folic acid and tHcy level did not correlate with male infertility. Pooled estimate on c.1298A>C data from all published studies including our data showed no association of this polymorphism with male infertility (Odds ratio?=?1.035, P?=?0.56), azoospermia (Odds ratio?=?0.97, P?=?0.74), or oligoasthenoteratozoospermia (Odds ratio?=?0.92, p?=?0.29). Eight haplotypes with more than 1% frequency were detected, of which CCGA was protective against infertility (p?=?0.02), but the significance of the latter was not seen after applying Bonferroni correction.Among MTHFR polymorphisms, c.203G>A and c.1298A>C do not affect infertility risk and c.1793G>A is protective against… Continue reading →