Molecular mechanisms

Mitochondrial Dysfunction, Oxidative Stress, and Major Depressive Disorder.

Mitochondrial dysfunction, oxidative stress, and major depressive disorder.

Neuropsychiatr Dis Treat. 2013; 9: 567-73
Tobe EH

There is controversy about depression being a physical illness, in part because a reproducible, sensitive, and specific biologic marker is not available. However,… Continue reading

Regulation Where Autophagy Intersects the Inflammasome.

Regulation where autophagy intersects the inflammasome.

Antioxid Redox Signal. 2013 May 5;
Rodgers MA, Bowman JW, Liang Q, Jung JU

Significance: The autophagy and inflammasome pathways are ancient innate immune mechanisms for controlling invading pathogens that are linked by… Continue reading

Evaluation of Functional Relationship Between Mouse Hippocampal Cholinergic and Nitrergic Systems in Anxiogenic-Like Behavior.

Evaluation of functional relationship between mouse hippocampal cholinergic and nitrergic systems in anxiogenic-like behavior.

Behav Pharmacol. 2013 Jun; 24(3): 229-236
Zarrindast MR, Piri M, Bananej M, Shahab Z, Zahmatkesh M

Although a body of evidence shows the crucial role… Continue reading

Symptomatic Hallucal Interphalangeal Sesamoid Bones Successfully Treated With Ultrasound-Guided Injection – a Case Report -.

Symptomatic Hallucal Interphalangeal Sesamoid Bones Successfully Treated with Ultrasound-guided Injection – A Case Report -.

Korean J Pain. 2013 Apr; 26(2): 173-6
Shin HY, Park SY, Kim HY, Jung YS, An S, Kang do H

The hallucal interphalangeal sesamoid… Continue reading

Nicotine and Lung Cancer.

Nicotine and lung cancer.

J Carcinog. 2013; 12: 1
Warren GW, Singh AK

Tobacco use in cancer patients is associated with increased cancer treatment failure and decreased survival. Nicotine is one of over 7,000 compounds in tobacco smoke and… Continue reading

Will the EU Clinical Trials Regulation Support the Innovative Industry in Bringing New Medicines Faster to Patients?

Will the EU Clinical Trials Regulation Support the Innovative Industry in Bringing New Medicines Faster to Patients?

Pharmaceut Med. 2013 Apr; 27(2): 75-82
Atzor S, Gokhale S, Doherty M

A perspective from the innovative industry is provided in this… Continue reading

Neural Correlates of Impulsivity in Healthy Males and Females With Family-Histories of Alcoholism.

Neural Correlates of Impulsivity in Healthy Males and Females with Family-Histories of Alcoholism.

Neuropsychopharmacology. 2013 Apr 12;
Devito EE, Meda SA, Jiantonio R, Potenza MN, Krystal JH, Pearlson GD

Individuals family-history positive for alcoholism (FHP) have increased risk for… Continue reading

Molecular Aging of the Brain, Neuroplasticity, and Vulnerability to Depression and Other Brain-Related Disorders.

Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders.

Dialogues Clin Neurosci. 2013 Mar; 15(1): 53-65
Sibille E

The increased risk for neurodegenerative and neuropsychiatric disorders associated with extended lifespan has long suggested mechanistic… Continue reading

Towards Polypharmacokinetics: Pharmacokinetics of Multicomponent Drugs and Herbal Medicines Using a Metabolomics Approach.

Towards polypharmacokinetics: pharmacokinetics of multicomponent drugs and herbal medicines using a metabolomics approach.

Evid Based Complement Alternat Med. 2013; 2013: 819147
Lan K, Xie G, Jia W

Determination of pharmacokinetics (PKs) of multicomponent pharmaceuticals and/or nutraceuticals (polypharmacokinetics, poly-PKs) is… Continue reading

Dependence Is Not Addiction and “tolerance” Declares Addiction.

Dependence is not addiction and “tolerance” declares addiction.

JAMA Intern Med. 2013 Apr 8; 173(7): 595-6
Geller AS

HubMed – addiction

 

Acute ketamine-induced neuroplasticity: ribosomal protein S6 phosphorylation expression in drug addiction-related rat brain areas.

Neuroreport. 2013… Continue reading