Mass spectrometry

Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors.

Published April 23, 2013

Pharmacodynamic analysis of magnetic resonance imaging-monitored focused ultrasound-induced blood-brain barrier opening for drug delivery to brain tumors.

Biomed Res Int. 2013; 2013: 627496
Chu PC, Chai WY, Hsieh HY, Wang JJ, Wey SP, Huang CY, Wei KC, Liu HL… Continue reading →

UHPLC-MS/MS and UHPLC-HRMS Identification of Zolpidem and Zopiclone Main Urinary Metabolites and Method Development for Their Toxicological Determination.

Published March 21, 2013

UHPLC-MS/MS and UHPLC-HRMS identification of zolpidem and zopiclone main urinary metabolites and method development for their toxicological determination.

Drug Test Anal. 2013 Mar 19;
Strano Rossi S, Anzillotti L, Castrignanò E, Frison G, Zancanaro F, Chiarotti M

Zolpidem and… Continue reading →

Deoxyhypusine Hydroxylase From Plasmodium Vivax, the Neglected Human Malaria Parasite: Molecular Cloning, Expression and Specific Inhibition by the 5-LOX Inhibitor Zileuton.

Published March 19, 2013

Deoxyhypusine Hydroxylase from Plasmodium vivax, the Neglected Human Malaria Parasite: Molecular Cloning, Expression and Specific Inhibition by the 5-LOX Inhibitor Zileuton.

PLoS One. 2013; 8(3): e58318
Atemnkeng VA, Pink M, Schmitz-Spanke S, Wu XJ, Dong LL, Zhao KH, May… Continue reading →

Comparative Performance of Two Drug Interaction Screening Programmes Analysing a Cross-Sectional Prescription Dataset of 84,625 Psychiatric Inpatients.

Published March 16, 2013

Comparative Performance of Two Drug Interaction Screening Programmes Analysing a Cross-Sectional Prescription Dataset of 84,625 Psychiatric Inpatients.

Drug Saf. 2013 Mar 14;
Zorina OI, Haueis P, Greil W, Grohmann R, Kullak-Ublick GA, Russmann S

BACKGROUND: Clinical decision support software… Continue reading →

Analysis of Novel Melphalan Hydrolysis Products Formed Under Isolated Lung Perfusion Conditions Using Liquid Chromatography/tandem Mass Spectrometry.

Published March 16, 2013

Analysis of novel melphalan hydrolysis products formed under isolated lung perfusion conditions using liquid chromatography/tandem mass spectrometry.

Rapid Commun Mass Spectrom. 2013 Apr 15; 27(7): 835-841
Boschmans J, de Bruijn E, Van Schil P, Lemière F

RATIONALE: Melphalan is a widely used cytotoxic agent in cancer treatments. This phenylalanine analog has been shown an effective drug in the treatment of breast cancer, multiple myeloma and melanoma of the extremities. A good knowledge of the drug’s degradation and metabolism are crucial for understanding its activity during cancer treatments. METHODS: The formation of hydrolysis products of melphalan is studied using ultra-performance liquid chromatography (UPLC) tandem mass spectrometry (MS/MS). Aqueous melphalan solutions were incubated at elevated temperatures and analyzed by UPLC/MS/MS. Two previously described hydrolysis products, mono- and dihydroxymelphalan (MOH and DOH), were formed in vitro and could be characterized during MS/MS and high-resolution experiments. RESULTS: Novel compounds with m/z values >500?Da were discovered.… Continue reading →

Treating Tuberculosis: Time to Introduce Fixed-Dose Drug Combinations.

Published March 16, 2013

Treating Tuberculosis: Time to Introduce Fixed-Dose Drug Combinations.

J Young Pharm. 2012 10; 4(4): 199-200
Manikandan S

HubMed – drug

The Role of Phenethyl Isothiocyanate on Bladder Cancer ADM Resistance Reversal and Its Molecular Mechanism.

Anat Rec (Hoboken)… Continue reading →

Weak Affinity Chromatography for Evaluation of Stereoisomers in Early Drug Discovery.

Published March 13, 2013

Weak Affinity Chromatography for Evaluation of Stereoisomers in Early Drug Discovery.

J Biomol Screen. 2013 Mar 11;
Duong-Thi MD, Bergström M, Fex T, Svensson S, Ohlson S, Isaksson R

In early drug discovery (e.g., in fragment screening), recognition of… Continue reading →

Effects of Oral Fluid Contamination on Two Oral Fluid Testing Systems.

Published March 9, 2013

Effects of Oral Fluid Contamination on Two Oral Fluid Testing Systems.

J Anal Toxicol. 2013 Mar 6;
Reichardt EM, Baldwin D, Osselton MD

Oral fluid is a popular matrix for drug testing; however, little has been published concerning the… Continue reading →

Plasma Pharmacochemistry Combined With Microdialysis to Screen Potential Bioactive Components and Their Metabolites in Anemarrhena Asphodeloides Saponin Extract Using Ultrahigh-Performance Liquid Chromatography/quadrupole-Time-of-Flight Mass Spectrometry.

Published March 8, 2013

Plasma pharmacochemistry combined with microdialysis to screen potential bioactive components and their metabolites in Anemarrhena asphodeloides saponin extract using ultrahigh-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.

J Sep Sci. 2013 Mar 6;
Liu Z, Liu M, Qi Y, Zhu Z, Chai… Continue reading →

Macrophage Scavenger Receptor a Promotes Tumor Progression in Murine Models of Ovarian and Pancreatic Cancer.

Published March 1, 2013

Macrophage Scavenger Receptor A Promotes Tumor Progression in Murine Models of Ovarian and Pancreatic Cancer.

J Immunol. 2013 Feb 27;
Neyen C, Plüddemann A, Mukhopadhyay S, Maniati E, Bossard M, Gordon S, Hagemann T

Alternatively activated macrophages express the… Continue reading →

Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors.

UHPLC-MS/MS and UHPLC-HRMS Identification of Zolpidem and Zopiclone Main Urinary Metabolites and Method Development for Their Toxicological Determination.

Deoxyhypusine Hydroxylase From Plasmodium Vivax, the Neglected Human Malaria Parasite: Molecular Cloning, Expression and Specific Inhibition by the 5-LOX Inhibitor Zileuton.

Comparative Performance of Two Drug Interaction Screening Programmes Analysing a Cross-Sectional Prescription Dataset of 84,625 Psychiatric Inpatients.

Analysis of Novel Melphalan Hydrolysis Products Formed Under Isolated Lung Perfusion Conditions Using Liquid Chromatography/tandem Mass Spectrometry.

Treating Tuberculosis: Time to Introduce Fixed-Dose Drug Combinations.

Weak Affinity Chromatography for Evaluation of Stereoisomers in Early Drug Discovery.

Effects of Oral Fluid Contamination on Two Oral Fluid Testing Systems.

Plasma Pharmacochemistry Combined With Microdialysis to Screen Potential Bioactive Components and Their Metabolites in Anemarrhena Asphodeloides Saponin Extract Using Ultrahigh-Performance Liquid Chromatography/quadrupole-Time-of-Flight Mass Spectrometry.

Macrophage Scavenger Receptor a Promotes Tumor Progression in Murine Models of Ovarian and Pancreatic Cancer.

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