liquid chromatography

Analysis of Novel Melphalan Hydrolysis Products Formed Under Isolated Lung Perfusion Conditions Using Liquid Chromatography/tandem Mass Spectrometry.

Published March 16, 2013

Analysis of novel melphalan hydrolysis products formed under isolated lung perfusion conditions using liquid chromatography/tandem mass spectrometry.

Rapid Commun Mass Spectrom. 2013 Apr 15; 27(7): 835-841
Boschmans J, de Bruijn E, Van Schil P, Lemière F

RATIONALE: Melphalan is a widely used cytotoxic agent in cancer treatments. This phenylalanine analog has been shown an effective drug in the treatment of breast cancer, multiple myeloma and melanoma of the extremities. A good knowledge of the drug’s degradation and metabolism are crucial for understanding its activity during cancer treatments. METHODS: The formation of hydrolysis products of melphalan is studied using ultra-performance liquid chromatography (UPLC) tandem mass spectrometry (MS/MS). Aqueous melphalan solutions were incubated at elevated temperatures and analyzed by UPLC/MS/MS. Two previously described hydrolysis products, mono- and dihydroxymelphalan (MOH and DOH), were formed in vitro and could be characterized during MS/MS and high-resolution experiments. RESULTS: Novel compounds with m/z values >500?Da were discovered.… Continue reading →

Treating Tuberculosis: Time to Introduce Fixed-Dose Drug Combinations.

Published March 16, 2013

Treating Tuberculosis: Time to Introduce Fixed-Dose Drug Combinations.

J Young Pharm. 2012 10; 4(4): 199-200
Manikandan S

HubMed – drug

The Role of Phenethyl Isothiocyanate on Bladder Cancer ADM Resistance Reversal and Its Molecular Mechanism.

Anat Rec (Hoboken)… Continue reading →

Bioequivalence Study of Pantoprazole Sodium-HPBCD and Conventional Pantoprazole Sodium Enteric-Coated Tablet Formulations.

Published March 13, 2013

Bioequivalence Study of Pantoprazole Sodium-HPBCD and Conventional Pantoprazole Sodium Enteric-Coated Tablet Formulations.

ISRN Pharmacol. 2013; 2013: 347457
Kamdi SP, Palkar PJ

The objective of this study was to investigate the bioequivalence of two formulations of 40?mg pantoprazole sodium enteric-coated… Continue reading →

Effects of Oral Fluid Contamination on Two Oral Fluid Testing Systems.

Published March 9, 2013

Effects of Oral Fluid Contamination on Two Oral Fluid Testing Systems.

J Anal Toxicol. 2013 Mar 6;
Reichardt EM, Baldwin D, Osselton MD

Oral fluid is a popular matrix for drug testing; however, little has been published concerning the… Continue reading →

Effectiveness of the Histone Deacetylase Inhibitor (S)-2 Against LNCaP and PC3 Human Prostate Cancer Cells.

Published March 8, 2013

Effectiveness of the Histone Deacetylase Inhibitor (S)-2 against LNCaP and PC3 Human Prostate Cancer Cells.

PLoS One. 2013; 8(3): e58267
Laurenzana A, Balliu M, Cellai C, Romanelli MN, Paoletti F

Histone deacetylase inhibitors (HDACi) represent a promising class of… Continue reading →

Plasma Pharmacochemistry Combined With Microdialysis to Screen Potential Bioactive Components and Their Metabolites in Anemarrhena Asphodeloides Saponin Extract Using Ultrahigh-Performance Liquid Chromatography/quadrupole-Time-of-Flight Mass Spectrometry.

Published March 8, 2013

Plasma pharmacochemistry combined with microdialysis to screen potential bioactive components and their metabolites in Anemarrhena asphodeloides saponin extract using ultrahigh-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.

J Sep Sci. 2013 Mar 6;
Liu Z, Liu M, Qi Y, Zhu Z, Chai… Continue reading →

[Development of Glipizide Push-Pull Osmotic Pump Controlled Release Tablets by Using Expert System and Artificial Neural Network].

Published March 6, 2013

[Development of glipizide push-pull osmotic pump controlled release tablets by using expert system and artificial neural network].

Yao Xue Xue Bao. 2012 Dec; 47(12): 1687-95
Zhang ZH, Wang Y, Wu WF, Zhao X, Sun XC, Wang HQ

The purpose… Continue reading →

Serum Concentrations and Hypoglycemic Effect of Gliclazide:crosspovidone Solid Dispersion on Streptozotocin Induced Diabetic Rats.

Published February 22, 2013

Serum concentrations and hypoglycemic effect of gliclazide:crosspovidone solid dispersion on streptozotocin induced diabetic rats.

Drug Res (Stuttg). 2013 Feb; 63(2): 94-7
Adibkia K, Babaei H, Asnaashari S, Andalib S, Khorrami A, Ghavimi H, Jadidinia V, Hajiloo H, Barzegar-Jalali M… Continue reading →

Adult Psychiatric Outcomes of Bullying and Being Bullied by Peers in Childhood and Adolescence.

Published February 22, 2013

Adult Psychiatric Outcomes of Bullying and Being Bullied by Peers in Childhood and Adolescence.

JAMA Psychiatry. 2013 Feb 20; 1-8
Copeland WE, Wolke D, Angold A, Costello EJ

IMPORTANCE Both bullies and victims of bullying are at risk for… Continue reading →

Frequency and Nature of Drug-Drug Interactions in the Intensive Care Unit.

Published February 20, 2013

Frequency and nature of drug-drug interactions in the intensive care unit.

Filed under: Drug and Alcohol Rehabilitation

Pharmacoepidemiol Drug Saf. 2013 Feb 18;
Askari M, Eslami S, Louws M, Wierenga PC, Dongelmans DA, Kuiper RA, Abu-Hanna A

PURPOSE: Drug-drug… Continue reading →