HIV Infection

Vagal Nerve Stimulator: Evolving Trends.

Published May 2, 2013

Vagal nerve stimulator: Evolving trends.

J Nat Sci Biol Med. 2013 Jan; 4(1): 8-13
Ogbonnaya S, Kaliaperumal C

Over three decades ago, it was found that intermittent electrical stimulation from the vagus nerve produces inhibition of neural processes, which… Continue reading →

Alcohol Use and Subsequent Sex Among HIV-Infected Patients in an Ethnic Minority Area of Yunnan Province, China.

Published May 1, 2013

Alcohol Use and Subsequent Sex among HIV-Infected Patients in an Ethnic Minority Area of Yunnan Province, China.

PLoS One. 2013; 8(4): e61660
Luo X, Duan S, Duan Q, Pu Y, Yang Y, Ding Y, Gao M, He N

To… Continue reading →

Prevalence Survey of Infection With Treponema Pallidum Among HIV-Positive Patients in Tehran.

Published April 27, 2013

Prevalence survey of infection with Treponema pallidum among HIV-positive patients in Tehran.

Asian Pac J Trop Biomed. 2013 Apr; 3(4): 334-6
Badie , Yavari Z, Esmaeeli S, Paydary K, Emamzadeh-Fard S, Seyedalinaghi S, Rasoulinejad M, Mohraz M

To identify… Continue reading →

Reliability of Classifying Multiple Sclerosis Disease Activity Using Magnetic Resonance Imaging in a Multiple Sclerosis Clinic.

Published April 20, 2013

Reliability of classifying multiple sclerosis disease activity using magnetic resonance imaging in a multiple sclerosis clinic.

JAMA Neurol. 2013 Mar 1; 70(3): 338-44
Erbayat Altay E, Fisher E, Jones SE, Hara-Cleaver C, Lee JC, Rudick RA

To assess the… Continue reading →

Effect of Acetazolamide for Long-Lasting Paroxysmal Dystonia in a Patient With Multiple Sclerosis: A Case Report and Review of Literature.

Published April 17, 2013

Effect of acetazolamide for long-lasting paroxysmal dystonia in a patient with multiple sclerosis: a case report and review of literature.

Neuropsychiatr Dis Treat. 2013; 9: 445-8
Hsieh PC, Chen SM, Guo YH, Kuan TS, Yen WJ, Chang WC, Lin… Continue reading →

Re-Directing an Alkylating Agent to Mitochondria Alters Drug Target and Cell Death Mechanism.

Published April 16, 2013

Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism.

PLoS One. 2013; 8(4): e60253
Mourtada R, Fonseca SB, Wisnovsky SP, Pereira MP, Wang X, Hurren R, Parfitt J, Larsen L, Smith RA, Murphy MP, Schimmer… Continue reading →

Inhibition of Dopamine Transporter Activity by G Protein ?? Subunits.

Published April 5, 2013

Inhibition of Dopamine Transporter Activity by G Protein ?? Subunits.

PLoS One. 2013; 8(3): e59788
Garcia-Olivares J, Torres-Salazar D, Owens WA, Baust T, Siderovski DP, Amara SG, Zhu J, Daws LC, Torres GE

Uptake through the Dopamine Transporter (DAT)… Continue reading →

Functionalized Graphene Oxide Mediated Adriamycin Delivery and miR-21 Gene Silencing to Overcome Tumor Multidrug Resistance in Vitro.

Published March 26, 2013

Functionalized Graphene Oxide Mediated Adriamycin Delivery and miR-21 Gene Silencing to Overcome Tumor Multidrug Resistance In Vitro.

PLoS One. 2013; 8(3): e60034
Zhi F, Dong H, Jia X, Guo W, Lu H, Yang Y, Ju H, Zhang X, Hu… Continue reading →

Stroke in a Patient With Tuberculous Meningitis and HIV Infection.

Published March 19, 2013

Stroke in a Patient with Tuberculous Meningitis and HIV Infection.

Mediterr J Hematol Infect Dis. 2013; 5(1): e2013017
Pasticci MB, Paciaroni M, Floridi P, Cecchini E, Baldelli F

Tuberculous meningitis (TBM) is a devastating disease. TBM occurs more commonly… Continue reading →

Analysis of Novel Melphalan Hydrolysis Products Formed Under Isolated Lung Perfusion Conditions Using Liquid Chromatography/tandem Mass Spectrometry.

Published March 16, 2013

Analysis of novel melphalan hydrolysis products formed under isolated lung perfusion conditions using liquid chromatography/tandem mass spectrometry.

Rapid Commun Mass Spectrom. 2013 Apr 15; 27(7): 835-841
Boschmans J, de Bruijn E, Van Schil P, Lemière F

RATIONALE: Melphalan is a widely used cytotoxic agent in cancer treatments. This phenylalanine analog has been shown an effective drug in the treatment of breast cancer, multiple myeloma and melanoma of the extremities. A good knowledge of the drug’s degradation and metabolism are crucial for understanding its activity during cancer treatments. METHODS: The formation of hydrolysis products of melphalan is studied using ultra-performance liquid chromatography (UPLC) tandem mass spectrometry (MS/MS). Aqueous melphalan solutions were incubated at elevated temperatures and analyzed by UPLC/MS/MS. Two previously described hydrolysis products, mono- and dihydroxymelphalan (MOH and DOH), were formed in vitro and could be characterized during MS/MS and high-resolution experiments. RESULTS: Novel compounds with m/z values >500?Da were discovered.… Continue reading →