Hepatitis C virus

Recombinant Human Butyrylcholinesterase as a New-Age Bioscavenger Drug: Development of the Expression System.

Recombinant human butyrylcholinesterase as a new-age bioscavenger drug: development of the expression system.

Acta Naturae. 2013 Jan; 5(1): 73-84
Ilyushin DG, Haertley OM, Bobik TV, Shamborant OG, Surina EA, Knorre VD, Masson P, Smirnov IV, Gabibov AG, Ponomarenko NA… Continue reading →

RASopathic Skin Eruptions During Vemurafenib Therapy.

RASopathic Skin Eruptions during Vemurafenib Therapy.

PLoS One. 2013; 8(3): e58721
Rinderknecht JD, Goldinger SM, Rozati S, Kamarashev J, Kerl K, French LE, Dummer R, Belloni B

Vemurafenib is a potent inhibitor of V600 mutant BRAF with significant impact… Continue reading →

Analysis of Novel Melphalan Hydrolysis Products Formed Under Isolated Lung Perfusion Conditions Using Liquid Chromatography/tandem Mass Spectrometry.

Analysis of novel melphalan hydrolysis products formed under isolated lung perfusion conditions using liquid chromatography/tandem mass spectrometry.

Rapid Commun Mass Spectrom. 2013 Apr 15; 27(7): 835-841
Boschmans J, de Bruijn E, Van Schil P, Lemière F

RATIONALE: Melphalan is a widely used cytotoxic agent in cancer treatments. This phenylalanine analog has been shown an effective drug in the treatment of breast cancer, multiple myeloma and melanoma of the extremities. A good knowledge of the drug’s degradation and metabolism are crucial for understanding its activity during cancer treatments. METHODS: The formation of hydrolysis products of melphalan is studied using ultra-performance liquid chromatography (UPLC) tandem mass spectrometry (MS/MS). Aqueous melphalan solutions were incubated at elevated temperatures and analyzed by UPLC/MS/MS. Two previously described hydrolysis products, mono- and dihydroxymelphalan (MOH and DOH), were formed in vitro and could be characterized during MS/MS and high-resolution experiments. RESULTS: Novel compounds with m/z values >500?Da were discovered.… Continue reading →

“We Lost All We Had in a Second”: Coping With Grief and Loss After a Natural Disaster.

“We lost all we had in a second”: coping with grief and loss after a natural disaster.

World Psychiatry. 2013 Feb; 12(1): 69-75
Ekanayake S, Prince M, Sumathipala A, Siribaddana S, Morgan C

Natural disasters cause immense suffering among… Continue reading →

Episodic Sexual Addiction in a Depressed Woman Treated With Cyproterone Acetate.

Episodic Sexual Addiction in a Depressed Woman Treated With Cyproterone Acetate.

Filed under: Addiction Rehab

J Clin Psychopharmacol. 2013 Feb 14;
Dardennes R, Al Anbar N, Rouillon F

HubMed – addiction

 

Trends in Opioid Agonist Therapy in the… Continue reading →

Neonatal Visual Evoked Potentials in Infants Born to Mothers Prescribed Methadone.

Neonatal Visual Evoked Potentials in Infants Born to Mothers Prescribed Methadone.

Filed under: Drug and Alcohol Rehabilitation

Pediatrics. 2013 Feb 18;
McGlone L, Hamilton R, McCulloch DL, Boulton R, Bradnam MS, Weaver LT, Mactier H

OBJECTIVE:Drug misuse in pregnancy… Continue reading →

Drug and Alcohol Rehabilitation: Treatment Outcomes of Treatment-Naïve Hepatitis C Patients Co-Infected With HIV: A Systematic Review and Meta-Analysis of Observational Cohorts.

Treatment Outcomes of Treatment-Naïve Hepatitis C Patients Co-Infected with HIV: A Systematic Review and Meta-Analysis of Observational Cohorts.

Filed under: Drug and Alcohol Rehabilitation

PLoS One. 2013; 8(2): e55373
Davies A, Singh KP, Shubber Z, Ducros P, Mills EJ,… Continue reading →

Prevalent and Incident Hepatitis C Virus Infection Among HIV-Infected Men Who Have Sex With Men Engaged in Primary Care in a Boston Community Health Center.

Prevalent and Incident Hepatitis C Virus Infection among HIV-Infected Men Who Have Sex with Men Engaged in Primary Care in a Boston Community Health Center.

Filed under: Drug and Alcohol Rehabilitation

Clin Infect Dis. 2013 Feb 5;
Garg S,… Continue reading →

What’s Conditioned in Conditioned Place Preference?

What’s conditioned in conditioned place preference?

Filed under: Addiction Rehab

Trends Pharmacol Sci. 2013 Feb 2;
Huston JP, Silva MA, Topic B, Müller CP

Conditioned place preference (CPP) is a learned behavior shown in many vertebrates, including humans. CPP… Continue reading →

Safety and Effectiveness of a Nurse-Led Outreach Program for Assessment and Treatment of Chronic Hepatitis C in the Custodial Setting.

Safety and Effectiveness of a Nurse-Led Outreach Program for Assessment and Treatment of Chronic Hepatitis C in the Custodial Setting.

Filed under: Drug and Alcohol Rehabilitation

Clin Infect Dis. 2013 Jan 29;
Lloyd AR, Clegg J, Lange J, Stevenson… Continue reading →