Hepatitis C virus

Recombinant Human Butyrylcholinesterase as a New-Age Bioscavenger Drug: Development of the Expression System.

Recombinant human butyrylcholinesterase as a new-age bioscavenger drug: development of the expression system.

Acta Naturae. 2013 Jan; 5(1): 73-84
Ilyushin DG, Haertley OM, Bobik TV, Shamborant OG, Surina EA, Knorre VD, Masson P, Smirnov IV, Gabibov AG, Ponomarenko NA… Continue reading

RASopathic Skin Eruptions During Vemurafenib Therapy.

RASopathic Skin Eruptions during Vemurafenib Therapy.

PLoS One. 2013; 8(3): e58721
Rinderknecht JD, Goldinger SM, Rozati S, Kamarashev J, Kerl K, French LE, Dummer R, Belloni B

Vemurafenib is a potent inhibitor of V600 mutant BRAF with significant impact… Continue reading

Analysis of Novel Melphalan Hydrolysis Products Formed Under Isolated Lung Perfusion Conditions Using Liquid Chromatography/tandem Mass Spectrometry.

Analysis of novel melphalan hydrolysis products formed under isolated lung perfusion conditions using liquid chromatography/tandem mass spectrometry.

Rapid Commun Mass Spectrom. 2013 Apr 15; 27(7): 835-841
Boschmans J, de Bruijn E, Van Schil P, Lemière F

RATIONALE: Melphalan is a widely used cytotoxic agent in cancer treatments. This phenylalanine analog has been shown an effective drug in the treatment of breast cancer, multiple myeloma and melanoma of the extremities. A good knowledge of the drug’s degradation and metabolism are crucial for understanding its activity during cancer treatments. METHODS: The formation of hydrolysis products of melphalan is studied using ultra-performance liquid chromatography (UPLC) tandem mass spectrometry (MS/MS). Aqueous melphalan solutions were incubated at elevated temperatures and analyzed by UPLC/MS/MS. Two previously described hydrolysis products, mono- and dihydroxymelphalan (MOH and DOH), were formed in vitro and could be characterized during MS/MS and high-resolution experiments. RESULTS: Novel compounds with m/z values >500?Da were discovered.… Continue reading

“We Lost All We Had in a Second”: Coping With Grief and Loss After a Natural Disaster.

“We lost all we had in a second”: coping with grief and loss after a natural disaster.

World Psychiatry. 2013 Feb; 12(1): 69-75
Ekanayake S, Prince M, Sumathipala A, Siribaddana S, Morgan C

Natural disasters cause immense suffering among… Continue reading

Episodic Sexual Addiction in a Depressed Woman Treated With Cyproterone Acetate.

Episodic Sexual Addiction in a Depressed Woman Treated With Cyproterone Acetate.

Filed under: Addiction Rehab

J Clin Psychopharmacol. 2013 Feb 14;
Dardennes R, Al Anbar N, Rouillon F

HubMed – addiction

 

Trends in Opioid Agonist Therapy in the… Continue reading

Neonatal Visual Evoked Potentials in Infants Born to Mothers Prescribed Methadone.

Neonatal Visual Evoked Potentials in Infants Born to Mothers Prescribed Methadone.

Filed under: Drug and Alcohol Rehabilitation

Pediatrics. 2013 Feb 18;
McGlone L, Hamilton R, McCulloch DL, Boulton R, Bradnam MS, Weaver LT, Mactier H

OBJECTIVE:Drug misuse in pregnancy… Continue reading

Drug and Alcohol Rehabilitation: Treatment Outcomes of Treatment-Naïve Hepatitis C Patients Co-Infected With HIV: A Systematic Review and Meta-Analysis of Observational Cohorts.

Treatment Outcomes of Treatment-Naïve Hepatitis C Patients Co-Infected with HIV: A Systematic Review and Meta-Analysis of Observational Cohorts.

Filed under: Drug and Alcohol Rehabilitation

PLoS One. 2013; 8(2): e55373
Davies A, Singh KP, Shubber Z, Ducros P, Mills EJ,… Continue reading

Prevalent and Incident Hepatitis C Virus Infection Among HIV-Infected Men Who Have Sex With Men Engaged in Primary Care in a Boston Community Health Center.

Prevalent and Incident Hepatitis C Virus Infection among HIV-Infected Men Who Have Sex with Men Engaged in Primary Care in a Boston Community Health Center.

Filed under: Drug and Alcohol Rehabilitation

Clin Infect Dis. 2013 Feb 5;
Garg S,… Continue reading

What’s Conditioned in Conditioned Place Preference?

What’s conditioned in conditioned place preference?

Filed under: Addiction Rehab

Trends Pharmacol Sci. 2013 Feb 2;
Huston JP, Silva MA, Topic B, Müller CP

Conditioned place preference (CPP) is a learned behavior shown in many vertebrates, including humans. CPP… Continue reading

Safety and Effectiveness of a Nurse-Led Outreach Program for Assessment and Treatment of Chronic Hepatitis C in the Custodial Setting.

Safety and Effectiveness of a Nurse-Led Outreach Program for Assessment and Treatment of Chronic Hepatitis C in the Custodial Setting.

Filed under: Drug and Alcohol Rehabilitation

Clin Infect Dis. 2013 Jan 29;
Lloyd AR, Clegg J, Lange J, Stevenson… Continue reading