Differentiation in the Protein Synthesis-Dependency of Persistent Synaptic Plasticity in Mossy Fiber and Associational/commissural CA3 Synapses in Vivo.
Differentiation in the protein synthesis-dependency of persistent synaptic plasticity in mossy fiber and associational/commissural CA3 synapses in vivo.
Front Integr Neurosci. 2013; 7: 10
Hagena H, Manahan-Vaughan D
Long-term potentiation (LTP) and long-term depression (LTD) are two mechanisms involved in the long-term storage of information in hippocampal synapses. In the hippocampal CA1 region, the late phases of LTP and LTD are protein-synthesis dependent. In the dentate gyrus, late-LTP but not LTD requires protein synthesis. The protein synthesis-dependency of persistent plasticity at CA3 synapses has not yet been characterized. Here, the roles of protein transcription and translation at mossy fiber (mf) and associational/commissural (AC)- synapses were studied in freely behaving rats. In control animals, low-frequency stimulation (LFS) evoked robust LTD (>24 h), whereas high-frequency stimulation (HFS) elicited robust LTP (>24 h) at both mf-CA3 and AC-CA3 synapses. Translation inhibitors prevented early and late phases of LTP and LTD at mf-CA3 synapses. In contrast, at AC-CA3 synapses, translation inhibitors prevented intermediate/late-LTP and late-LTD only. Transcription effects were also synapse-specific: whereas transcription inhibitors inhibited late-LTP and late-LTD (>3 h) at mf-CA3 synapses, at AC-CA3 synapses, protein transcription affected… Continue reading
[Antidepressant Activities of Flavonoids From Glycyrrhiza Uralensis and Its Neurogenesis Protective Effect in Rats].
[Antidepressant activities of flavonoids from Glycyrrhiza uralensis and its neurogenesis protective effect in rats].
Yao Xue Xue Bao. 2012 Dec; 47(12): 1612-7
Fan ZZ, Zhao WH, Guo J, Cheng RF, Zhao JY, Yang WD, Wang YH, Li W, Peng… Continue reading
Depression Treatment: Anxiety and Depression Are Associated With Migraine and Pain in General: An Investigation of the Interrelationships.
Anxiety and Depression Are Associated With Migraine and Pain in General: An Investigation of the Interrelationships.
Filed under: Depression Treatment
J Pain. 2013 Feb 5;
Ligthart L, Gerrits MM, Boomsma DI, Penninx BW
There is a well-established comorbidity between… Continue reading
Differences Between “Just Feeling Depressed” and Serious Depression
Differences Between “Just Feeling Depressed” and Serious Depression – There are key differences between “feeling depressed” – sadness – and serious depression, Major Depression. HealthyPlace.com Medical Director, Dr. Harry Croft, provides an explanation. For comprehensive information on depression, visit… Continue reading
Antipsychotic Medications for Treatment of Major Depression
Antipsychotic Medications for Treatment of Major Depression – For depression patients who don’t get relief with antidepressant medications alone, adding antipsychotic medications, like Seroquel or Abilify, may help. HealthyPlace.com Medical Director, Dr. Harry Croft, says for patients with tough-to-treat… Continue reading
Depression Treatment: Maternal Interpersonal Affiliation Is Associated With Adolescents’ Brain Structure and Reward Processing.
Maternal interpersonal affiliation is associated with adolescents’ brain structure and reward processing.
Filed under: Depression Treatment
Transl Psychiatry. 2012; 2: e182
Schneider S, Brassen S, Bromberg U, Banaschewski T, Conrod P, Flor H, Gallinat J, Garavan H, Heinz A,… Continue reading
Can You Determine a Cause of an Eating Disorder?
Question by danb135: Can you determine a cause of an eating disorder?
Can you really determine a cause of an eating disorder? I know A person can have pre exsisting condition that can assist them. like depression and other… Continue reading