Future Prospects for Pharmacogenetics in the Quest for Personalized Medicine.
Future prospects for pharmacogenetics in the quest for personalized medicine.
J Psychosoc Nurs Ment Health Serv. 2012 Dec; 50(12): 13-6
Howland RH
Understanding pharmacogenetic differences in drug response and tolerability has been an important area of research in personalized… Continue reading
Identification of (2-Aminopropyl)benzofuran (APB) Phenyl Ring Positional Isomers in Internet Purchased Products.
Identification of (2-aminopropyl)benzofuran (APB) phenyl ring positional isomers in Internet purchased products.
Filed under: Addiction Rehab
Drug Test Anal. 2013 Jan 24;
Stanczuk A, Morris N, Gardner EA, Kavanagh P
5-(2-Aminopropyl)benzofuran (5-APB), a ‘research chemical’ that was first reported… Continue reading
Drug and Alcohol Rehabilitation: Inducible Nitric Oxide Synthase Haplotype Associated With Hypertension and Responsiveness to Antihypertensive Drug Therapy.
Inducible nitric oxide synthase haplotype associated with hypertension and responsiveness to antihypertensive drug therapy.
Filed under: Drug and Alcohol Rehabilitation
Gene. 2012 Dec 21;
Oliveira-Paula GH, Lacchini R, Coeli-Lacchini FB, Junior HM, Tanus-Santos JE
Hypertension is a multifactorial disorder associated with increased inducible nitric oxide synthase (iNOS) expression and activity. While genetic polymorphisms affect iNOS expression, it is not known whether iNOS gene polymorphisms affect the susceptibility to hypertension and the responses to antihypertensive therapy. This study aimed at assessing whether iNOS polymorphisms ((CCTTT)(n), g.-1026C>A, and g.2087G>A) and haplotypes are associated with hypertension and with responsiveness to drug therapy. We studied 115 well controlled hypertensive patients (HTN), 82 hypertensive patients resistant to optimized antihypertensive therapy (RHTN), and 113 normotensive healthy subjects (NT). Genotypings were carried out using real-time polymerase chain reaction (PCR) and PCR amplification followed by capillary electrophoresis. The software PHASE 2.1 was used to estimate the haplotypes frequencies in each group. Variant genotypes (GA+AA) for the g.2087G>A polymorphism were more commonly found in hypertensive patients (HTN+RHTN) than in normotensives (P=0.016; OR=2.05). We found no associations between genotypes and responsiveness to therapy (P>0.05). The S-C-A haplotype was more commonly found in hypertensive patients (HTN+RHTN) than in normotensives (P=0.014; OR=6.07). Interestingly, this haplotype was more commonly found in the HTN group than in the RHTN group (P=0.012; OR=0.14). Our findings indicate that the g.2087G>A polymorphism in the iNOS… Continue reading
Prevalence of Current, 12-Month and Lifetime Major Depressive Disorder Among Patients With Systemic Sclerosis.
Prevalence of current, 12-month and lifetime major depressive disorder among patients with systemic sclerosis.
Filed under: Depression Treatment
Rheumatology (Oxford). 2012 Dec 18;
Jewett LR, Razykov I, Hudson M, Baron M, Thombs BD,
Objectives. Patients with SSc experience a… Continue reading
Depression Treatment: No Association of Genetic Variants in BDNF With Major Depression: A Meta- and Gene-Based Analysis.
No association of genetic variants in BDNF with major depression: A meta- and gene-based analysis.
Filed under: Depression Treatment
Am J Med Genet B Neuropsychiatr Genet. 2012 Nov 26;
Gyekis JP, Yu W, Dong S, Wang H, Qian J,… Continue reading
Genome-Wide Association Study Identifies a Potent Locus Associated With Human Opioid Sensitivity.
Genome-wide association study identifies a potent locus associated with human opioid sensitivity.
Filed under: Eating Disorders
Mol Psychiatry. 2012 Nov 27;
Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Aoki Y, Nishi A, Saita N, Koukita Y, Nagashima M,… Continue reading