Depression Treatment: No Association of Genetic Variants in BDNF With Major Depression: A Meta- and Gene-Based Analysis.

No association of genetic variants in BDNF with major depression: A meta- and gene-based analysis.

Filed under: Depression Treatment

Am J Med Genet B Neuropsychiatr Genet. 2012 Nov 26;
Gyekis JP, Yu W, Dong S, Wang H, Qian J, Kota P, Yang J

Major depressive disorder (MDD) is a complex psychiatric condition with strong genetic predisposition. The association of MDD with genetic polymorphisms, such as Val66Met (rs6265), in the brain derived neurotrophic factor (BDNF), have been reported in many studies and the results were conflicting. In this study, we performed a systematic literature search and conducted random-effects meta-analysis to evaluate genetic variants in BDNF with MDD. A gene-based analysis was also conducted to investigate the cumulative effects of genetic polymorphisms in BDNF. A total of 28 studies from 26 published articles were included in our analysis. Meta-analysis yielded an estimated odds ratio (OR) of 0.96 (95% CI: 0.89-1.05; P?=?0.402) for Val66Met (rs6265), 0.83 (95% CI: 0.67-1.04; P?=?0.103) for 11757C/G, 1.16 (95% CI: 0.74-1.82; P?=?0.527) for 270T/C, 1.03 (95% CI: 0.18-5.75; P?=?0.974) for 712A/G and 0.98 (95% CI: 0.85-1.14; P?=?0.831) for rs988748. The gene-based analysis indicated that BDNF is not associated with MDD (P?>?0.21). Our updated meta- and novel gene-based analyses provide no evidence of the association of BDNF with major depression. © 2012 Wiley Periodicals, Inc.
HubMed – depression

Testing for Differential Item Functioning within the EQ-5D.

Filed under: Depression Treatment

Med Decis Making. 2012 Nov 26;
Whynes DK, Sprigg N, Selby J, Berge E, Bath PM,

We test for the presence of differential item functioning (DIF) in the EQ-5D health-related quality-of-life instrument, using data from a large clinical trial in acute stroke (ISRCTN 99414122). DIF occurs when subjects in different subsets of a sample respond differently to items in a measurement instrument, despite possessing the same latent traits. The data comprised 1462 patient records. We analyzed DIF specifically with respect to responses obtained from different geographical regions and responses obtained from proxies as opposed to the patients themselves. We mapped clinical outcome measures (scores from the modified Rankin Scale, the Barthel Index, and the Zung Depression scale) onto EQ-5D index scores and included dummy variables for proxy responses and for region of treatment (United Kingdom, Asia, rest of world). We predicted the level of problem severity reported on each of the EQ-5D’s five constituent dimensions from the clinical measures and the dummy variables. For given clinical characteristics, proxies were more likely to report health problems than were the patients themselves, although the divergences were not sufficiently large to result in any significant difference in mean index scores between patient and proxy reports. However, the distributions of reported levels of problems for similar clinical states diverged significantly by region, and these translated into different index scores. The mean index score for UK responses was significantly higher than the mean index scores from Asia and the rest of the world.
HubMed – depression

Onset of Posttraumatic Stress Disorder and Major Depression Among Refugees and Voluntary Migrants to the United States.

Filed under: Depression Treatment

J Trauma Stress. 2012 Nov 26;
Rasmussen A, Crager M, Baser RE, Chu T, Gany F

Although refugees are generally thought to be at increased risk for posttraumatic stress disorder (PTSD) and major depressive episode (MDE), few studies have compared onset of PTSD and MDE between refugees and voluntary migrants. Given differences in migration histories, onset should differ pre- and postmigration. The National Latino and Asian American Survey (NLAAS) is a national representative, complex dataset measuring psychiatric morbidity, mental health service use, and migration history among Latino and Asian immigrants to the United States. Of the 3,260 foreign-born participants, 660 were refugees (a weighted proportion of 9.52%). Refugees were more likely to report a history of war-related trauma, but reports of other traumatic events were similar. Premigration onset of PTSD was statistically higher for refugees than voluntary migrants, odds ratio (OR) = 4.86, 95% confidence interval (CI) [2.01, 11.76], where postmigration onset for PTSD was not, OR = 0.61, 95% CI [0.29, 1.28]; a similar pattern was found for MDE, OR = 1.98, 95% CI [1.11, 3.51]; and OR = 1.02, 95% CI [0.65, 1.62], respectively. Although refugees arrive in host countries with more pressing psychiatric needs, onset is comparable over time, suggesting that postmigration refugees and voluntary migrants may be best served by similar programs.
HubMed – depression

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