drug design

Rapid Countermeasure Discovery Against Francisella Tularensis Based on a Metabolic Network Reconstruction.

Rapid Countermeasure Discovery against Francisella tularensis Based on a Metabolic Network Reconstruction.

PLoS One. 2013; 8(5): e63369
Chaudhury S, Abdulhameed MD, Singh N, Tawa GJ, D’haeseleer PM, Zemla AT, Navid A, Zhou CE, Franklin MC, Cheung J, Rudolph MJ,… Continue reading

Prodrug Design, Synthesis and Pharmacokinetic Evaluation of (3′ R, 4′ R)-3-Hydroxymethyl-4-Methyl-3′,4′-Di-O-(S)-Camphanoyl-(+)-Cis-Khellactone.

Prodrug design, synthesis and pharmacokinetic evaluation of (3′ R, 4′ R)-3-hydroxymethyl-4-methyl-3′,4′-di-O-(S)-camphanoyl-(+)-cis-khellactone.

Acta Pharm Sin B. 2012 Apr 1; 2(2): 213-219
Guo H, Zhuang X, Qian K, Sun L, Wang X, Li H, Lee K, Xie L

3-Hydroxymethyl-4-methyl-DCK (3, HMDCK)… Continue reading

Evaluation of Genetically Inactivated Alpha Toxin for Protection in Multiple Mouse Models of Staphylococcus Aureus Infection.

Evaluation of Genetically Inactivated Alpha Toxin for Protection in Multiple Mouse Models of Staphylococcus aureus Infection.

PLoS One. 2013; 8(4): e63040
Brady RA, Mocca CP, Prabhakara R, Plaut RD, Shirtliff ME, Merkel TJ, Burns DL

Staphylococcus aureus is a… Continue reading

In Vitro Selection of Mutant HDM2 Resistant to Nutlin Inhibition.

In Vitro Selection of Mutant HDM2 Resistant to Nutlin Inhibition.

PLoS One. 2013; 8(4): e62564
Wei SJ, Joseph T, Sim AY, Yurlova L, Zolghadr K, Lane D, Verma C, Ghadessy F

HDM2 binds to the p53 tumour suppressor and… Continue reading

Development of an HPLC-UV Method for the Analysis of Drugs Used for Combined Hypertension Therapy in Pharmaceutical Preparations and Human Plasma.

Development of an HPLC-UV Method for the Analysis of Drugs Used for Combined Hypertension Therapy in Pharmaceutical Preparations and Human Plasma.

J Anal Methods Chem. 2013; 2013: 179627
Kepekci Tekkeli SE

A simple, rapid, and selective HPLC-UV method was… Continue reading

Characteristics of Opioid-Users Whose Death Was Related to Opioid-Toxicity: A Population-Based Study in Ontario, Canada.

Characteristics of opioid-users whose death was related to opioid-toxicity: a population-based study in ontario, Canada.

PLoS One. 2013; 8(4): e60600
Madadi P, Hildebrandt D, Lauwers AE, Koren G

The impact of the prescription opioid public health crisis has been… Continue reading

Reply: Drug Concentration Monitoring in Mycobacterium Avium Lung Disease: Problems With Methods and Conclusions.

Reply: drug concentration monitoring in Mycobacterium avium lung disease: problems with methods and conclusions.

Am J Respir Crit Care Med. 2013 Mar 1; 187(5): 555-6
Koh WJ, Jeong BH, Jeon K, Lee SY, Shin SJ

HubMed – drug

 … Continue reading

Adherence Challenges and Long-Acting Injectable Antipsychotic Treatment in Patients With Schizophrenia.

Adherence challenges and long-acting injectable antipsychotic treatment in patients with schizophrenia.

J Psychosoc Nurs Ment Health Serv. 2013 Mar; 51(3): 13-8
Kirk Morton N, Zubek D

Medication nonadherence has been associated with persistence of psychotic symptoms, relapse, and hospitalization… Continue reading

CXCR4 Expression and Treatment With SDF-1? or Plerixafor Modulate Proliferation and Chemosensitivity of Colon Cancer Cells.

CXCR4 Expression and Treatment with SDF-1? or Plerixafor Modulate Proliferation and Chemosensitivity of Colon Cancer Cells.

Transl Oncol. 2013 Apr; 6(2): 124-32
Heckmann D, Maier P, Laufs S, Wenz F, Zeller WJ, Fruehauf S, Allgayer H

Signaling through stromal… Continue reading

Novel Phenolic Inhibitors of Small/Intermediate-Conductance Ca(2+)-Activated K(+) Channels, KCa3.1 and KCa2.3.

Novel Phenolic Inhibitors of Small/Intermediate-Conductance Ca(2+)-Activated K(+) Channels, KCa3.1 and KCa2.3.

PLoS One. 2013; 8(3): e58614
Oliván-Viguera A, Valero MS, Murillo MD, Wulff H, García-Otín AL, Arbonés-Mainar JM, Köhler R

BACKGROUND: KCa3.1 channels are calcium/calmodulin-regulated voltage-independent K(+) channels that… Continue reading