drug design

Role of Ess1 in Growth, Morphogenetic Switching, and RNA Polymerase II Transcription in Candida Albicans.

Role of Ess1 in Growth, Morphogenetic Switching, and RNA Polymerase II Transcription in Candida albicans.

PLoS One. 2013; 8(3): e59094
Samaranayake D, Atencio D, Morse R, Wade JT, Chaturvedi V, Hanes SD

Candida albicans is a fungal pathogen that… Continue reading

Predicting Where Small Molecules Bind at Protein-Protein Interfaces.

Predicting where Small Molecules Bind at Protein-Protein Interfaces.

PLoS One. 2013; 8(3): e58583
Walter P, Metzger J, Thiel C, Helms V

Small molecules that bind at protein-protein interfaces may either block or stabilize protein-protein interactions in cells. Thus, some… Continue reading

Stroke in a Patient With Tuberculous Meningitis and HIV Infection.

Stroke in a Patient with Tuberculous Meningitis and HIV Infection.

Mediterr J Hematol Infect Dis. 2013; 5(1): e2013017
Pasticci MB, Paciaroni M, Floridi P, Cecchini E, Baldelli F

Tuberculous meningitis (TBM) is a devastating disease. TBM occurs more commonly… Continue reading

Simultaneous Quantitation of Venlafaxine and Its Main Metabolite, O-Desmethylvenlafaxine, in Human Saliva by HPLC.

Simultaneous quantitation of venlafaxine and its main metabolite, O-desmethylvenlafaxine, in human saliva by HPLC.

J Sep Sci. 2013 Mar 12;
Dziurkowska E, Wesolowski M

Venlafaxine is used for the treatment of major depression and generalized anxiety disorders. Because its… Continue reading

The Relationship of Copper to DNA Damage and Damage Prevention in Humans.

The relationship of copper to DNA damage and damage prevention in humans.

Mutat Res. 2012 May 1; 733(1-2): 83-91
Linder MC

Copper ions are well suited to facilitate formation of reactive oxygen species (ROS) that can damage biomolecules, including… Continue reading

The Μ Opioid Receptor and Ligands Acting at the Μ Opioid Receptor, as Therapeutics and Potential Therapeutics.

The µ Opioid Receptor and Ligands Acting at the µ Opioid Receptor, as Therapeutics and Potential Therapeutics.

Curr Pharm Des. 2013 Feb 20;
Spetea M, Asim MF, Wolber G, Schmidhammer H

Although the µ opioid receptor (MOR) was pharmacologically… Continue reading

Drug and Alcohol Rehabilitation: Protein-Chemical Interaction Prediction via Kernelized Sparse Learning Svm.

Protein-chemical interaction prediction via kernelized sparse learning svm.

Filed under: Drug and Alcohol Rehabilitation

Pac Symp Biocomput. 2013; 41-52
Shi Y, Zhang X, Liao X, Lin G, Schuurmans D

Given the difficulty of experimental determination of drug-protein interactions, there… Continue reading

Analysis of the Functional Polymorphism in the Cytochrome P450 CYP2C8 Gene Rs11572080 With Regard to Colorectal Cancer Risk.

Analysis of the Functional Polymorphism in the Cytochrome P450 CYP2C8 Gene rs11572080 with Regard to Colorectal Cancer Risk.

Filed under: Drug and Alcohol Rehabilitation

Front Genet. 2012; 3: 278
Ladero JM, Agúndez JA, Martínez C, Amo G, Ayuso P,… Continue reading

Drug and Alcohol Rehabilitation: Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond.

Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond.

Filed under: Drug and Alcohol Rehabilitation

Front Pharmacol. 2013; 4: 5
Davidson D, Amrein L, Panasci L, Aloyz R

Many current chemotherapies function by damaging genomic DNA in rapidly… Continue reading

[Zebrafish as a Model Animal for the Study of Blood-Brain Barrier Permeability by Biomolecules].

[Zebrafish as a model animal for the study of blood-brain barrier permeability by biomolecules].

Filed under: Drug and Alcohol Rehabilitation

Yao Xue Xue Bao. 2012 Nov; 47(11): 1447-51
Fu AL, Chen HY, Xu XR, Zhao BQ

Blood-brain barrier (BBB)… Continue reading