cancer treatment

[The Clinical Efficacy of a Succinate-Containing Infusion Drug During Pharmacotherapy for Hepatic Lesions of Varying Genesis: Results of Meta-Analysis].

Published March 29, 2013

[The clinical efficacy of a succinate-containing infusion drug during pharmacotherapy for hepatic lesions of varying genesis: results of meta-analysis].

Ter Arkh. 2013; 85(1): 56-61

To pool the published results of trials of the new infusion hepatoprotector remaxol for the… Continue reading →

Self-Inflicted Male Bladder Foreign Body: Its Endoscopic Removal Using a Rigid Cystoscope and a Suprapubic Forceps.

Published March 28, 2013

Self-inflicted male bladder foreign body: its endoscopic removal using a rigid cystoscope and a suprapubic forceps.

Case Rep Urol. 2013; 2013: 729013
Moslemi MK, Sorani M

Introduction. Herein we present an interesting technique for the removal of bladder foreign… Continue reading →

Functionalized Graphene Oxide Mediated Adriamycin Delivery and miR-21 Gene Silencing to Overcome Tumor Multidrug Resistance in Vitro.

Published March 26, 2013

Functionalized Graphene Oxide Mediated Adriamycin Delivery and miR-21 Gene Silencing to Overcome Tumor Multidrug Resistance In Vitro.

PLoS One. 2013; 8(3): e60034
Zhi F, Dong H, Jia X, Guo W, Lu H, Yang Y, Ju H, Zhang X, Hu… Continue reading →

Cocaine Abuse and Sleep Apnea in Severe Obesity.

Published March 24, 2013

Cocaine Abuse and Sleep Apnea in Severe Obesity.

J Addict Med. 2013 Mar 20;
Marzullo P, Menegatti M, Guzzaloni G, Fanari P, Uccelli E, Tagliaferri MA, Aimaretti G, Liuzzi A

Obesity is a cause of sleep breathing disorders that… Continue reading →

Analysis of Novel Melphalan Hydrolysis Products Formed Under Isolated Lung Perfusion Conditions Using Liquid Chromatography/tandem Mass Spectrometry.

Published March 16, 2013

Analysis of novel melphalan hydrolysis products formed under isolated lung perfusion conditions using liquid chromatography/tandem mass spectrometry.

Rapid Commun Mass Spectrom. 2013 Apr 15; 27(7): 835-841
Boschmans J, de Bruijn E, Van Schil P, Lemière F

RATIONALE: Melphalan is a widely used cytotoxic agent in cancer treatments. This phenylalanine analog has been shown an effective drug in the treatment of breast cancer, multiple myeloma and melanoma of the extremities. A good knowledge of the drug’s degradation and metabolism are crucial for understanding its activity during cancer treatments. METHODS: The formation of hydrolysis products of melphalan is studied using ultra-performance liquid chromatography (UPLC) tandem mass spectrometry (MS/MS). Aqueous melphalan solutions were incubated at elevated temperatures and analyzed by UPLC/MS/MS. Two previously described hydrolysis products, mono- and dihydroxymelphalan (MOH and DOH), were formed in vitro and could be characterized during MS/MS and high-resolution experiments. RESULTS: Novel compounds with m/z values >500?Da were discovered.… Continue reading →

Treating Tuberculosis: Time to Introduce Fixed-Dose Drug Combinations.

Published March 16, 2013

Treating Tuberculosis: Time to Introduce Fixed-Dose Drug Combinations.

J Young Pharm. 2012 10; 4(4): 199-200
Manikandan S

HubMed – drug

The Role of Phenethyl Isothiocyanate on Bladder Cancer ADM Resistance Reversal and Its Molecular Mechanism.

Anat Rec (Hoboken)… Continue reading →

Correction of Drug-Induced Hepatotoxicity With New Triterpene Derivatives in Transplanted RLS Lymphoma.

Published March 14, 2013

Correction of Drug-Induced Hepatotoxicity with New Triterpene Derivatives in Transplanted RLS Lymphoma.

Bull Exp Biol Med. 2012 Dec; 154(3): 370-374
Zhukova NA, Semenov DE, Bessergeneva EP, Sorokina IV, Tolstikova TG

The hepatoprotective effects of new triterpene derivatives, betulin 3?,28-di-O-nicotinate… Continue reading →

Stress, Anxiety, and Depression in the Legal Profession – Part One

Published March 6, 2013

Stress, Anxiety, and Depression In The Legal Profession – Part One – Daniel T. Lukasik, author of LawyersWithDepression.com, shares his experience regarding Stress, Anxiety, and Depression surrounding the legal profession. This is the first of two full segments of… Continue reading →

Future Prospects for Pharmacogenetics in the Quest for Personalized Medicine.

Published March 5, 2013

Future prospects for pharmacogenetics in the quest for personalized medicine.

J Psychosoc Nurs Ment Health Serv. 2012 Dec; 50(12): 13-6
Howland RH

Understanding pharmacogenetic differences in drug response and tolerability has been an important area of research in personalized… Continue reading →

mTORC2 Controls Actin Polymerization Required for Consolidation of Long-Term Memory.

Published March 5, 2013

mTORC2 controls actin polymerization required for consolidation of long-term memory.

Nat Neurosci. 2013 Mar 3;
Huang W, Zhu PJ, Zhang S, Zhou H, Stoica L, Galiano M, Krnjevi? K, Roman G, Costa-Mattioli M

A major goal of biomedical research… Continue reading →