Alzheimer’s disease

Insight in Alzheimer’s Disease and Its Relation to Psychiatric and Behavioral Disturbances.

Insight in Alzheimer’s disease and its relation to psychiatric and behavioral disturbances.

Int J Geriatr Psychiatry. 2013 May 14;
Horning SM, Melrose R, Sultzer D

OBJECTIVE: Individuals suffering from Alzheimer’s disease (AD) often have impaired awareness or a lack… Continue reading

Pearls and Pitfalls in Experimental Models of Spreading Depression.

Pearls and pitfalls in experimental models of spreading depression.

Cephalalgia. 2013 Jun; 33(8): 604-13
Ayata C

Spreading depression (SD) is the electrophysiological substrate of migraine aura and a potential trigger for headache. Since its discovery by Leão in 1944,… Continue reading

Strategies to Improve Recruitment and Retention of Older Stroke Survivors to a Randomized Clinical Exercise Trial.

Strategies to Improve Recruitment and Retention of Older Stroke Survivors to a Randomized Clinical Exercise Trial.

J Stroke Cerebrovasc Dis. 2013 May 2;
Taylor-Piliae RE, Boros D, Coull BM

BACKGROUND: Relatively few exercise randomized clinical trials (RCTs) among stroke… Continue reading

Inconsolable Infant Crying and Maternal Postpartum Depressive Symptoms.

Inconsolable Infant Crying and Maternal Postpartum Depressive Symptoms.

Pediatrics. 2013 May 6;
Radesky JS, Zuckerman B, Silverstein M, Rivara FP, Barr M, Taylor JA, Lengua LJ, Barr RG

OBJECTIVE:To quantify the extent to which maternal report of inconsolable infant crying, rather than colic (defined by Wessel’s criteria of daily duration of fussing and crying >3 hours), is associated with maternal postpartum depressive symptoms.METHODS:Participants were 587 mothers who were recruited shortly before or after delivery and followed longitudinally. At 5 to 6 weeks postpartum, mothers recorded the duration and mode (fussing, crying, or inconsolable crying) of their infant’s distress by using the Baby’s Day Diary. The Edinburgh Postnatal Depression Scale (EPDS) was administered at enrollment and at 8 weeks postpartum. Using regression models that included baseline EPDS scores and multiple confounders, we examined associations of colic and inconsolable crying with later maternal EPDS scores at 8 weeks postpartum.RESULTS:Sixty mothers (10%) met the EPDS threshold for “possible depression” (score ?9) at 8 weeks postpartum. For mothers reporting >20 minutes of inconsolable crying per day, the adjusted odds ratio… Continue reading

Machine Learning Prediction of Cancer Cell Sensitivity to Drugs Based on Genomic and Chemical Properties.

Machine learning prediction of cancer cell sensitivity to drugs based on genomic and chemical properties.

PLoS One. 2013; 8(4): e61318
Menden MP, Iorio F, Garnett M, McDermott U, Benes CH, Ballester PJ, Saez-Rodriguez J

Predicting the response of a… Continue reading

Cannabinoid and Opioid Interactions: Implications for Opiate Dependence and Withdrawal.

Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal.

Neuroscience. 2013 Apr 24;
Scavone JL, Sterling RC, Van Bockstaele EJ

Withdrawal from opiates, such as heroin or oral narcotics, is characterized by a host of aversive physical and… Continue reading

Consanguineous Mating, Specialization, and the Environment: How Multiple Variable Interactions Affect the Evolution of Dioecy.

Consanguineous mating, specialization, and the environment: How multiple variable interactions affect the evolution of dioecy.

Am J Bot. 2013 Apr 25;
Sinclair JP, Maxwell GD, Freeman DC

• Premise: The evolution of dioecy in plants is usually modeled as… Continue reading

Drinking Patterns of Older Adults With Chronic Medical Conditions.

Drinking Patterns of Older Adults with Chronic Medical Conditions.

J Gen Intern Med. 2013 Apr 23;
Ryan M, Merrick EL, Hodgkin D, Horgan CM, Garnick DW, Panas L, Ritter G, Blow FC, Saitz R

BACKGROUND: Understanding alcohol consumption patterns… Continue reading

Amylin Uncovered: A Review on the Polypeptide Responsible for Type II Diabetes.

Amylin Uncovered: A Review on the Polypeptide Responsible for Type II Diabetes.

Biomed Res Int. 2013; 2013: 826706
Pillay K, Govender P

Amylin is primarily responsible for classifying type II diabetes as an amyloid (protein misfolding) disease as it… Continue reading

Screening of the Antidepressant-Like Effect of the Traditional Chinese Medicinal Formula Si-Ni-San and Their Possible Mechanism of Action in Mice.

Screening of the antidepressant-like effect of the traditional Chinese medicinal formula Si-Ni-San and their possible mechanism of action in mice.

Pharmacognosy Res. 2013 1; 5(1): 36-42
Yi LT, Li J, Liu BB, Li CF

The traditional Chinese medicine formula… Continue reading