Microinjection of Ghrelin in the Nucleus Accumbens Core Enhances Locomotor Activity Induced by Cocaine.
... site. When ghrelin alone microinjected, basal locomotor activity was unchanged. These results expand previous similar findings obtained by systemic ghrelin to more specific neuronal site, the nucleus accumbens core, and further suggest that it may work in this site… Continue reading
HDAC3 Is a Negative Regulator of Cocaine-Context-Associated Memory Formation.
... mice exhibit significantly enhanced CPP acquisition, which is correlated with increased gene expression during the consolidation phase of acquisition. Increased gene expression of c-Fos and Nr4a2 is correlated with decreased HDAC3 occupancy and increased histone H4 lysine 8 acetylation… Continue reading
Hepatitis C Treatment for Multimorbid Patients With Substance Use Disorder in a Primary Care-Based Integrated Treatment Centre: A Retrospective Analysis.
... use of different supporting strategies allows for treatment success rates in the population of PWUD that is comparable to the ones in the population of patients without drug use. Heroin maintenance treatment programmes offer a feasible and safe setting… Continue reading
Detection of Epigenetic Changes Using ANOVA With Spatially Varying Coefficients.
... following repeated treatment, these persistent effects on functional activity in the caudate putamen and septum may provide insights into the way in which baclofen alters the reinforcing effects of abused substances such as cocaine, alcohol, and methamphetamine both in… Continue reading
Neurofeedback-Mediated Self-Regulation of the Dopaminergic Midbrain.
... self-regulation of the dopaminergic midbrain. Neuroimage. 2013 Mar 1; Sulzer J, Sitaram R, Blefari ML, Kollias S, Birbaumer N, Stephan KE, Luft A, Gassert R The dopaminergic system is involved in reward encoding and reinforcement learning. Dopaminergic neurons from… Continue reading
Who Do You Think Is in Control in Addiction? a Pilot Study on Drug-Related Locus of Control Beliefs.
... of a low dose alcohol (2?g/kg) were absent in ?CaMKIIT286A mice, while the sedating effects of high dose (3.5?g/kg) were preserved, after acute and subchronic administration. In-vivo microdialysis revealed that ?CaMKIIT286A mice showed no dopamine (DA) response in the… Continue reading
Caloric Restriction Increases the Sensitivity to the Hyperphagic Effect of Nociceptin/orphanin FQ Limiting Its Ability to Reduce Binge Eating in Female Rats.
... injections of N/OFQ of 0.5 nmol/rat significantly reduced BE. N/OFQ 1 nmol/rat did not reduce BE but significantly increased HPF intake following food restrictions. Cycles of food restriction increased animals’ sensitivity to the hyperphagic effect of N/OFQ… Continue reading