synaptic plasticity

PICK1 Interacts With PACSIN to Regulate AMPA Receptor Internalization and Cerebellar Long-Term Depression.

PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression.

Proc Natl Acad Sci U S A. 2013 Aug 5;
Anggono V, Koç-Schmitz Y, Widagdo J, Kormann J, Quan A, Chen CM, Robinson PJ, Choi SY,… Continue reading

A Prolyl-Isomerase Mediates Dopamine-Dependent Plasticity and Cocaine Motor Sensitization.

A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization.

Cell. 2013 Aug 1; 154(3): 637-50
Park JM, Hu JH, Milshteyn A, Zhang PW, Moore CG, Park S, Datko MC, Domingo RD, Reyes CM, Wang XJ, Etzkorn FA, Xiao B,… Continue reading

A Nine-Year Follow-Up Study of Sleep Patterns and Mortality in Community-Dwelling Older Adults in Taiwan.

A Nine-Year Follow-up Study of Sleep Patterns and Mortality in Community-Dwelling Older Adults in Taiwan.

Sleep. 2013; 36(8): 1187-98
Chen HC, Su TP, Chou P

To simultaneously explore the associations between mortality and insomnia, sleep duration, and the use of hypnotics in older adults.A fixed cohort study.A community in Shih-Pai area, Taipei, Taiwan.A total of 4,064 participants over the age of 65 completed the study.N/A.Insomnia was classified using an exclusionary hierarchical algorithm, which categorized insomnia as “no insomnia,” “subjective poor sleep quality,” “Pittsburgh Sleep Quality Index > 5 insomnia,” “1-month insomnia disorder,” and “6-month insomnia disorder.” The main outcome variables were 9-year all-cause mortality rates. In the all-cause mortality analyses, when hypnotic use, depressive symptoms and total sleep time were excluded from a proportional hazards regression model, subjects with “Pittsburgh Sleep Quality Index > 5 insomnia” had a higher mortality risk (HR: 1.21, 95% CI: 1.01-1.45). In the full model, frequent hypnotic use and long sleep duration predicted higher mortality rates. However, the increased mortality risk for subjects with “Pittsburgh Sleep Quality Index > 5 insomnia” was not observed in the full model. On the contrary, individuals with… Continue reading

The Story of Glutamate in Drug Addiction and of N-Acetylcysteine as a Potential Pharmacotherapy.

The Story of Glutamate in Drug Addiction and of N-Acetylcysteine as a Potential Pharmacotherapy.

JAMA Psychiatry. 2013 Jul 31;
Brown RM, Kupchik YM, Kalivas PW

HubMed – addiction

Pharmacological interventions to modulate attentional bias in addiction.

CNS Spectr.… Continue reading

Antidepressant Medication Use Among Patients With Depression: Comparison Between Usual Care and Collaborative Care Using Care Managers.

Antidepressant Medication Use Among Patients with Depression: Comparison between Usual Care and Collaborative Care Using Care Managers.

Clin Pract Epidemiol Ment Health. 2013; 9: 84-87
Dejesus RS, Angstman KB, Cha SS, Williams MD

Depression poses a significant economic and… Continue reading

The Effect of Acute Swim Stress and Training in the Water Maze on Hippocampal Synaptic Activity as Well as Plasticity in the Dentate Gyrus of Freely Moving Rats: Revisiting Swim-Induced LTP Reinforcement.

The effect of acute swim stress and training in the water maze on hippocampal synaptic activity as well as plasticity in the dentate gyrus of freely moving rats: Revisiting swim-induced LTP reinforcement.

Hippocampus. 2013 Jul 8;
Tabassum H, Frey… Continue reading

Molecular and Cellular Mechanisms of Dopamine-Mediated Behavioral Plasticity in the Striatum.

Molecular and cellular mechanisms of dopamine-mediated behavioral plasticity in the striatum.

Neurobiol Learn Mem. 2013 Jul 1;
Cerovic M, d’Isa R, Tonini R, Brambilla R

The striatum is the input structure of the basal ganglia system. By integrating glutamatergic… Continue reading

Development of a Positive Psychology Intervention for Patients With Acute Cardiovascular Disease.

Development of a positive psychology intervention for patients with acute cardiovascular disease.

Heart Int. 2011 Sep 29; 6(2): e14
Huffman JC, Mastromauro CA, Boehm JK, Seabrook R, Fricchione GL, Denninger JW, Lyubomirsky S

The management of depression and other… Continue reading

Suicidal Behavior in Dementia: A Special Risk in Semantic Dementia.

Suicidal Behavior in Dementia: A Special Risk in Semantic Dementia.

Am J Alzheimers Dis Other Demen. 2013 Jul 1;
Sabodash V, Mendez MF, Fong S, Hsiao JJ

Background:Some studies report a low suicide risk in general dementia and in… Continue reading

Decynium-22 Enhances SSRI-Induced Antidepressant-Like Effects in Mice: Uncovering Novel Targets to Treat Depression.

Decynium-22 Enhances SSRI-Induced Antidepressant-Like Effects in Mice: Uncovering Novel Targets to Treat Depression.

J Neurosci. 2013 Jun 19; 33(25): 10534-43
Horton RE, Apple DM, Owens WA, Baganz NL, Cano S, Mitchell NC, Vitela M, Gould GG, Koek W, Daws… Continue reading