Nuclear receptor

High-Throughput Screening for GPR119 Modulators Identifies a Novel Compound With Anti-Diabetic Efficacy in Db/db Mice.

High-Throughput Screening for GPR119 Modulators Identifies a Novel Compound with Anti-Diabetic Efficacy in db/db Mice.

PLoS One. 2013; 8(5): e63861
Zhang M, Feng Y, Wang J, Zhao J, Li T, He M, Yang D, Nosjean O, Boutin J, Renard… Continue reading

Demonstration of the Innate Electrophilicity of 4-(3-(Benzyloxy)phenyl)-2-(Ethylsulfinyl)-6-(Trifluoromethyl)pyrimidine (BETP), a Small Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 (GLP-1) Receptor.

Demonstration of the Innate Electrophilicity of 4-(3-(Benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a Small Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 (GLP-1) Receptor.

Drug Metab Dispos. 2013 May 7;
Eng H, Sharma R, McDonald TS, Edmonds DJ, Fortin JP, Li X, Stevens… Continue reading

Prevalence of Transmitted HIV Drug Resistance in Iran Between 2010 and 2011.

Prevalence of Transmitted HIV Drug Resistance in Iran between 2010 and 2011.

PLoS One. 2013; 8(4): e61864
Jahanbakhsh F, Hattori J, Matsuda M, Ibe S, Monavari SH, Memarnejadian A, Aghasadeghi MR, Mostafavi E, Mohraz M, Jabbari H, Kamali K,… Continue reading

Differential Targeting of Brain Stress Circuits With a Selective Glucocorticoid Receptor Modulator.

Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator.

Proc Natl Acad Sci U S A. 2013 Apr 23;
Zalachoras I, Houtman R, Atucha E, Devos R, Tijssen AM, Hu P, Lockey PM, Datson NA, Belanoff… Continue reading

Expression of the PXR Gene in Various Types of Cancer and Drug Resistance.

Expression of the PXR gene in various types of cancer and drug resistance.

Oncol Lett. 2013 Apr; 5(4): 1093-1100
Qiao E, Ji M, Wu J, Ma R, Zhang X, He Y, Zha Q, Song X, Zhu LW, Tang J… Continue reading

[Research Progress of Self-Assembled Beads Drug Delivery System Prepared From Cyclodextrins and Oils].

[Research progress of self-assembled beads drug delivery system prepared from cyclodextrins and oils].

Yao Xue Xue Bao. 2012 Dec; 47(12): 1582-6
Liu C, Yi T

Recently, increasing attention has been paid to beads, an innovative self-assembled drug delivery system… Continue reading

Macromolecular Prodrugs of Ribavirin Combat Side Effects and Toxicity With No Loss of Activity of the Drug.

Macromolecular prodrugs of ribavirin combat side effects and toxicity with no loss of activity of the drug.

Chem Commun (Camb). 2013 Feb 22;
Kryger MB, Wohl BM, Smith AA, Zelikin AN

Chemi-enzymatic synthesis of ribavirin acrylate and subsequent RAFT… Continue reading

Addiction Rehab: Peroxisome Proliferator Activated Receptor-?/Hypoxia Inducible Factor-1? Interplay Sustains Carbonic Anhydrase IX and Apoliprotein E Expression in Breast Cancer Stem Cells.

Peroxisome Proliferator Activated Receptor-?/Hypoxia Inducible Factor-1? Interplay Sustains Carbonic Anhydrase IX and Apoliprotein E Expression in Breast Cancer Stem Cells.

Filed under: Addiction Rehab

PLoS One. 2013; 8(1): e54968
Papi A, Storci G, Guarnieri T, De Carolis S, Bertoni… Continue reading

Addiction Rehab: Novel Hsp90 Inhibitor NVP-AUY922 Radiosensitizes Prostate Cancer Cells.

Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells.

Filed under: Addiction Rehab

Cancer Biol Ther. 2013 Jan 28; 14(4):
Gandhi N, Wild AT, Chettiar ST, Aziz K, Kato Y, Gajula RP, Williams RD, Cades JA, Annadanam A, Song D,… Continue reading

Drug and Alcohol Rehabilitation: Murine Atrial HL-1 Cell Line Is a Reliable Model to Study Drug Metabolizing Enzymes in the Heart.

Murine Atrial HL-1 Cell Line is a Reliable Model to Study Drug Metabolizing Enzymes in the Heart.

Filed under: Drug and Alcohol Rehabilitation

Vascul Pharmacol. 2012 Dec 22;
Elshenawy OH, Anwar-Mohamed A, Abdelhamid G, El-Kadi AO

HL-1 cells are… Continue reading