Expression of the PXR Gene in Various Types of Cancer and Drug Resistance.

Expression of the PXR gene in various types of cancer and drug resistance.

Oncol Lett. 2013 Apr; 5(4): 1093-1100
Qiao E, Ji M, Wu J, Ma R, Zhang X, He Y, Zha Q, Song X, Zhu LW, Tang J

Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily of ligand-regulated transcription factors. PXR is a key xenobiotic receptor that regulates the expression of genes implicated in drug metabolism, detoxification and clearance, including drug metabolizing enzymes and transporters, suggesting that it is significant in the drug resistance of cancer cells. PXR is expressed in a wide range of tissues in the human body. Studies have demonstrated that PXR is expressed in a variety of tumor types, correlating not only with drug resistance but also with the cell proliferation, apoptosis and prognosis of cancer. The purpose of the present review is to provide a comprehensive review of PXR and its potential roles in multidrug resistance and the biological characteristics of PXR-positive tumors. HubMed – drug


American Society of Hematology.

P T. 2013 Feb; 38(2): 116-118
Alexander W

Drug therapies for multiple myeloma, mantle-cell lymphoma, and myelodysplastic syndromes. HubMed – drug


New Drugs/Drug News: New Medical Devices.

P T. 2013 Feb; 38(2): 75-85

FDA approvals, drug indications, and updates. HubMed – drug


Scanning Too Many Orders at Once: The Result: Drug Orders Are Omitted.

P T. 2013 Feb; 38(2): 67-68
Grissinger M

Drug orders can be accidentally omitted or misread if a scanner pulls too many pages through at once. HubMed – drug



Marathon Training blog – week 8 – Only 8 weeks to go for the OKC Memorial Marathon! Training is going great and the weather has been perfect, aside from some snow this week. Watch my latest v…