How to Optimize Binding of Coated Nanoparticles: Coupling of Physical Interactions, Molecular Organization and Chemical State.
... 99 days) and four NPC patients had stable disease (median duration of 92.5 days). Median progression-free survival (PFS) for HNSCC patients was 52 days (95% CI 43.0-99.0 days) and 48 days (95% CI 41.0-83.0 days) for NPC. Median overall… Continue reading
Pharmacology of Rasagiline, a New MAO-B Inhibitor Drug for the Treatment of Parkinson’s Disease With Neuroprotective Potential.
... leading causes of cancer-related death worldwide. Previous studies have shown that miR-92a has an oncogenic function in several cancers and that its up-regulation is correlated with malignant clinicopathologic behaviors of colorectal cancer. It also has been suggested that circulating… Continue reading
The Role of Morphology in Reading in Spanish-Speaking Children With Dyslexia.
... complex stimuli. These results indicate that they are able to develop representations of units larger than the grapheme, what suggests that Spanish-speaking children with dyslexia use the morphological structure to overcome their difficulties in phonological recoding. These results have… Continue reading
Zopolrestat as a Human Glyoxalase?I Inhibitor and Its Structural Basis.
... Jul 15; Fu C, Di L, Han X, Soderstrom CI, Snyder M, Troutman MD, Obach RS, Zhang H Aldehyde oxidase 1 (AOX1) is a cytosolic enzyme highly-expressed in liver and plays a key role in metabolizing drugs containing aromatic… Continue reading
Circulating Level of Lipocalin 2 as a Predictor of Severity in Patients With Community-Acquired Pneumonia.
... to hindlimb unloading for 7 or 14 days (7U, 14U), followed by 3, 7, or 14 days of reloading (3R, 7R, 14R). Results: Soleus muscle mass and tetanic force were reduced significantly at 7U and 14U and recovered by… Continue reading
Targeting Asymptomatic Malaria Infections: Active Surveillance in Control and Elimination.
... groups. Among patients who received palliative platinum-based doublet chemotherapy, progression free survival (PFS) was longer in the low-TG2 group than in the high-TG2 group (11.0 vs. 7.0 months; P=0.330). Among those who received EGFR-TKI therapy, PFS was also longer… Continue reading
Therapeutic Action of Fluoxetine Is Associated With a Reduction in Prefrontal Cortical miR-1971 Expression Levels in a Mouse Model of Posttraumatic Stress Disorder.
... Action of Fluoxetine is Associated with a Reduction in Prefrontal Cortical miR-1971 Expression Levels in a Mouse Model of Posttraumatic Stress Disorder. Front Psychiatry. 2013; 4: 66Schmidt U, Herrmann L, Hagl K, Novak B, Huber C, Holsboer F, Wotjak… Continue reading
Electroacupuncture at Quchi and Zusanli Treats Cerebral Ischemia-Reperfusion Injury Through Activation of ERK Signaling.
... treat stroke. However, the precise mechanism of its neuroprotective activities remains largely unknown. In the present study, a focal cerebral I/R-injured rat model was used to evaluate the in vivo therapeutic efficacy of electroacupuncture (EA) and investigate the underlying… Continue reading