Circulating Level of Lipocalin 2 as a Predictor of Severity in Patients With Community-Acquired Pneumonia.

Circulating level of lipocalin 2 as a predictor of severity in patients with community-acquired pneumonia.

J Clin Lab Anal. 2013 Jul; 27(4): 253-60
Yeh YH, Chang JL, Hsiao PC, Tsao SM, Lin CH, Kao SJ, Chou MC, Yang SF, Chien MH

The aim of this study was to investigate the differential plasma levels of lipocalin 2 (LCN2) and its complex with MMP-9 (where MMP is matrix metalloproteinase) before and after antibiotic treatment in hospitalized adult patients with community-acquired pneumonia (CAP).Plasma LCN2 and LCN2/MMP-9 complex levels were measured in 61 adult patients with CAP and 60 healthy controls using commercial enzyme-linked immunosorbent assay (ELISA).A decrease in the number of white blood cells (WBCs) and neutrophils and decreases in the levels of C-reactive protein (CRP), LCN2, and LCN2/MMP-9 complex were observed after antibiotic treatment. The plasma level of LCN2, but not that of CRP, was correlated with the severity of CAP based on the Pneumonia Severity Index (PSI; r = 0.333, P = 0.009), confusion, urea, respiratory rate and blood pressure (CURB)-65 (r = 0.288, P = 0.024), and Acute Physiology And Chronic Health Evaluation II (APACHE II) scores (r = 0.328, P = 0.010). LCN2 levels were also significantly correlated with LCN2/MMP-9 levels and the numbers of WBCs or neutrophils.Plasma levels of LCN2 and the LCN2/MMP-9 complex can act as adjuvant diagnostic biomarkers for CAP. Plasma LCN2 might play a further role in the clinical assessment of the severity of CAP, which could potentially guide the development of future treatment strategies. HubMed – rehab

CORR Insights(®): Factors Associated With Survey Response in Hand Surgery Research.

Clin Orthop Relat Res. 2013 Jul 13;
Freedman BA

HubMed – rehab

THE adaptive responses of TRPC1 and TRPC3 during skeletal muscle atrophy and regrowth.

Muscle Nerve. 2013 Jul 15;
Zhang BT, Yeung SS, Cheung KK, Chai ZY, Yeung EW

Introduction: We assessed the time-dependent changes of transient receptor potential channel 1 (TRPC1) and TRPC3 expression and localization associated with muscle atrophy and regrowth in vivo. Methods: Mice were subjected to hindlimb unloading for 7 or 14 days (7U, 14U), followed by 3, 7, or 14 days of reloading (3R, 7R, 14R). Results: Soleus muscle mass and tetanic force were reduced significantly at 7U and 14U and recovered by 14R. Recovery of muscle fiber cross-sectional area was observed by 28R. TRPC1 mRNA was unaltered during the unloading-reloading period. However, protein expression remained depressed through 14R. Decreased localization of TRPC1 to the sarcolemma was observed. TRPC3 mRNA and protein expression levels were decreased significantly during the early phase of reloading. Discussion: Given the known role of these channels in muscle development, changes observed in TRPC1 and TRPC3 may relate closely to the muscle atrophy and remodeling processes. © 2013 Wiley Periodicals, Inc. HubMed – rehab