Effectiveness of Miltefosine Treatment in Targeting Anti-Leishmanial HO-1/Nrf-2-Mediated Oxidative Responses in Visceral Leishmaniasis Patients.
Effectiveness of miltefosine treatment in targeting anti-leishmanial HO-1/Nrf-2-mediated oxidative responses in visceral leishmaniasis patients.
J Antimicrob Chemother. 2013 May 31;
Das S, Pandey K, Rabidas VN, Mandal A, Das P
OBJECTIVES: Miltefosine, an alkylphosphocholine anti-cancer drug, exhibits direct activity… Continue reading
Beyond Anti-VEGF: Dual-Targeting Antiangiogenic and Antiproliferative Therapy.
Beyond anti-VEGF: dual-targeting antiangiogenic and antiproliferative therapy.
Am J Transl Res. 2013; 5(4): 393-403
Chen CT, Hung MC
Antiangiogenesis is a promising antitumor strategy that inhibits tumor vascular formation to suppress tumor growth. Specifically, targeting VEGF has shown therapeutic… Continue reading
Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy.
Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy.
Front Oncol. 2013; 3: 120
Godwin P, Baird AM, Heavey S, Barr MP, O’Byrne KJ, Gately K
Intrinsic or acquired resistance to chemotherapeutic agents is a common phenomenon and a… Continue reading
Metformin Increases Mitochondrial Energy Formation in L6 Muscle Cell Cultures.
Metformin Increases Mitochondrial Energy Formation in L6 Muscle Cell Cultures.
J Biol Chem. 2013 May 29;
Vytla VS, Ochs RS
A popular hypothesis for the action of metformin, the widely used anti-diabetes drug, is the inhibition of mitochondrial respiration,… Continue reading
[Ibuprofen: Safety and Efficiency of Its Use in Wide Clinical Practice].
[Ibuprofen: safety and efficiency of its use in wide clinical practice].
Ter Arkh. 2013; 85(3): 118-24
The paper presents data on the pharmacokinetics of the nonsteroidal anti-inflammatory drug ibuprofen and a review of the evidence base that suggests its… Continue reading
BcL-xL Conformational Changes Upon Fragment Binding Revealed by NMR.
BcL-xL Conformational Changes upon Fragment Binding Revealed by NMR.
PLoS One. 2013; 8(5): e64400
Aguirre C, Ten Brink T, Walker O, Guillière F, Davesne D, Krimm I
Protein-protein interactions represent difficult but increasingly important targets for the design of… Continue reading
Proteomic Approach Toward Molecular Backgrounds of Drug Resistance of Osteosarcoma Cells in Spheroid Culture System.
Proteomic approach toward molecular backgrounds of drug resistance of osteosarcoma cells in spheroid culture system.
Proteomics. 2013 May 28;
Arai K, Sakamoto R, Kubota D, Kondo T
Chemoresistance is one of the most critical prognostic factors in osteosarcoma, and… Continue reading
Influence of Adult Height on Rheumatoid Arthritis: Association With Disease Activity, Impairment of Joint Function and Overall Disability.
Influence of Adult Height on Rheumatoid Arthritis: Association with Disease Activity, Impairment of Joint Function and Overall Disability.
PLoS One. 2013; 8(5): e64862
Chen Y, Yu Z, Packham JC, Mattey DL
To investigate whether normal variation of adult height… Continue reading