Drug interaction

Deubiquitylating Enzymes and DNA Damage Response Pathways.

Published May 30, 2013

... amenable to high-throughput screening because of speed, simplicity, versatility and low protein material requirements. The results suggest that kosmotrope-based solubility assessment has broad applicability to selecting protein therapeutic candidates with low aggregation propensity and high “developability” to progress into… Continue reading →

Pharmacotherapies for COPD.

Published May 25, 2013

... – drug Clinically significant interactions between antiretroviral and co-prescribed drugs for HIV-infected children: profiling and comparison of two drug databases. Ther Clin Risk Manag. 2013; 9: 215-221Oshikoya KA, Oreagba IA, Ogunleye OO, Lawal S, Senbanjo IO Drug-drug… Continue reading →

Assay Sensitivity and Study Features in Neuropathic Pain Trials: An ACTTION Meta-Analysis.

Published May 24, 2013

Assay sensitivity and study features in neuropathic pain trials: An ACTTION meta-analysis. Neurology. 2013 May 22; Dworkin RH, Turk DC, Peirce-Sandner S, He H, McDermott MP, Farrar JT, Katz NP, Lin AH, Rappaport BA, Rowbotham MC OBJECTIVE: Our objective was… Continue reading →

Non-Destructively Shattered Mesoporous Silica for Protein Drug Delivery.

Published May 21, 2013

Non-destructively shattered mesoporous silica for protein drug delivery. Microporous Mesoporous Mater. 2013 Jul 15; 175: 157-160Lei C, Chen B, Li X, Qi W, Liu J Mesoporous silicas have been extensively used for entrapping small chemical molecules and biomacromolecules for drug… Continue reading →

Drug-Like Property Profiling of Novel Neuroprotective Compounds to Treat Acute Ischemic Stroke: Guidelines to Develop Pleiotropic Molecules.

Published May 21, 2013

... used to show pleiotropic activity of a series of novel compounds; including enhanced neuroprotective activity compared to the parent compound fisetin. Moreover, for preliminary drug de-risking or risk reduction during development, we used compound assessment in the CeeTox assay,… Continue reading →

A Bivalent Ligand Targeting the Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Heterodimers: Binding Affinity Versus Functional Activities.

Published May 18, 2013

A Bivalent Ligand Targeting the Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Heterodimers: Binding Affinity versus Functional Activities. Medchemcomm. 2013 May 1; 4(5): 847-851Yuan Y, Arnatt CK, El-Hage N, Dever SM, Jacob JC, Selley DE, Hauser KF, Zhang Y… Continue reading →

A Review of Potential Harmful Interactions Between Anticoagulant/Antiplatelet Agents and Chinese Herbal Medicines.

Published May 15, 2013

A Review of Potential Harmful Interactions between Anticoagulant/Antiplatelet Agents and Chinese Herbal Medicines. PLoS One. 2013; 8(5): e64255Tsai HH, Lin HW, Lu YH, Chen YL, Mahady GB BACKGROUND: The risks attributed to drug-herb interactions, even when known, are often ignored… Continue reading →

Differences in Predictors of Traditional and Cyber-Bullying: A 2-Year Longitudinal Study in Korean School Children.

Published May 4, 2013

Differences in predictors of traditional and cyber-bullying: a 2-year longitudinal study in Korean school children. Eur Child Adolesc Psychiatry. 2013 May; 22(5): 309-18Yang SJ, Stewart R, Kim JM, Kim SW, Shin IS, Dewey ME, Maskey S, Yoon JS Traditional bullying… Continue reading →

Metformin Downregulates the Insulin/IGF-I Signaling Pathway and Inhibits Different Uterine Serous Carcinoma (USC) Cells Proliferation and Migration in P53-Dependent or -Independent Manners.

Published April 27, 2013

Metformin Downregulates the Insulin/IGF-I Signaling Pathway and Inhibits Different Uterine Serous Carcinoma (USC) Cells Proliferation and Migration in p53-Dependent or -Independent Manners. PLoS One. 2013; 8(4): e61537Sarfstein R, Friedman Y, Attias-Geva Z, Fishman A, Bruchim I, Werner H Accumulating epidemiological… Continue reading →

Effect of a Resident Physician Educational Program on Pediatric Emergency Department Pharmacy Interventions and Medication Errors.

Published April 26, 2013

Effect of a resident physician educational program on pediatric emergency department pharmacy interventions and medication errors. J Pediatr Pharmacol Ther. 2013 Jan; 18(1): 53-62Foster ME, Lighter DE, Godambe AV, Edgerson B, Bradley R, Godambe S To determine the effects of… Continue reading →