Drug discovery

Excessive MET Signaling Causes Acquired Resistance and Addiction to MET Inhibitors in the MKN45 Gastric Cancer Cell Line.

Excessive MET signaling causes acquired resistance and addiction to MET inhibitors in the MKN45 gastric cancer cell line.

Invest New Drugs. 2013 Apr 9;
Funakoshi Y, Mukohara T, Tomioka H, Ekyalongo RC, Kataoka Y, Inui Y, Kawamori Y, Toyoda… Continue reading

A Two-Step Similarity-Based Method for Prediction of Drug’s Target Group.

A two-step similarity-based method for prediction of drug’s target group.

Protein Pept Lett. 2013 Mar; 20(3): 364-70
Chen L, Zeng WM

Determination of drug’s target protein is very important for studying drug-target interaction network, while drug-target interaction network is… Continue reading

The Efficacy and Safety of Sertaconazole Cream (2 %) in Diaper Dermatitis Candidiasis.

The Efficacy and Safety of Sertaconazole Cream (2 %) in Diaper Dermatitis Candidiasis.

Mycopathologia. 2013 Apr 2;
Bonifaz A, Tirado-Sánchez A, Graniel MJ, Mena C, Valencia A, Ponce-Olivera RM

AIM: Diaper dermatitis (DD) is an inflammatory irritating condition… Continue reading

Novel Phenolic Inhibitors of Small/Intermediate-Conductance Ca(2+)-Activated K(+) Channels, KCa3.1 and KCa2.3.

Novel Phenolic Inhibitors of Small/Intermediate-Conductance Ca(2+)-Activated K(+) Channels, KCa3.1 and KCa2.3.

PLoS One. 2013; 8(3): e58614
Oliván-Viguera A, Valero MS, Murillo MD, Wulff H, García-Otín AL, Arbonés-Mainar JM, Köhler R

BACKGROUND: KCa3.1 channels are calcium/calmodulin-regulated voltage-independent K(+) channels that… Continue reading

Amitozyn Impairs Chromosome Segregation and Induces Apoptosis via Mitotic Checkpoint Activation.

Amitozyn Impairs Chromosome Segregation and Induces Apoptosis via Mitotic Checkpoint Activation.

PLoS One. 2013; 8(3): e57461
Herman B, Gudrun A, Potopalsky AI, Chroboczek J, Tcherniuk SO

Amitozyn (Am) is a semi-synthetic drug produced by the alkylation of major celandine… Continue reading

Protein-Protein Docking With F2Dock 2.0 and GB-Rerank.

Protein-Protein Docking with F2Dock 2.0 and GB-Rerank.

PLoS One. 2013; 8(3): e51307
Chowdhury R, Rasheed M, Keidel D, Moussalem M, Olson A, Sanner M, Bajaj C

Computational simulation of protein-protein docking can expedite the process of molecular modeling and… Continue reading

Propagation of Adult SSCs: From Mouse to Human.

Propagation of Adult SSCs: From Mouse to Human.

Biomed Res Int. 2013; 2013: 384734
Martin LA, Seandel M

Adult spermatogonial stem cells (SSCs) represent a distinctive source of stem cells in mammals for several reasons. First, by giving rise… Continue reading

Weak Affinity Chromatography for Evaluation of Stereoisomers in Early Drug Discovery.

Weak Affinity Chromatography for Evaluation of Stereoisomers in Early Drug Discovery.

J Biomol Screen. 2013 Mar 11;
Duong-Thi MD, Bergström M, Fex T, Svensson S, Ohlson S, Isaksson R

In early drug discovery (e.g., in fragment screening), recognition of… Continue reading

Efficient Generation of Stable Bispecific IgG1 by Controlled Fab-Arm Exchange.

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange.

Proc Natl Acad Sci U S A. 2013 Mar 11;
Labrijn AF, Meesters JI, de Goeij BE, van den Bremer ET, Neijssen J, van Kampen MD, Strumane K, Verploegen… Continue reading

Retroperitoneal Fibrosis: Role of Imaging in Diagnosis and Follow-Up.

Retroperitoneal Fibrosis: Role of Imaging in Diagnosis and Follow-up.

Radiographics. 2013 Mar; 33(2): 535-52
Caiafa RO, Vinuesa AS, Izquierdo RS, Brufau BP, Ayuso Colella JR, Molina CN

Retroperitoneal fibrosis (RPF) encompasses a range of diseases characterized by proliferation of… Continue reading