Drug discovery

Dose-Dependent Adverse Effects of Salinomycin on Male Reproductive Organs and Fertility in Mice.

Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice.

PLoS One. 2013; 8(7): e69086
Ojo OO, Bhadauria S, Rath SK

Salinomycin is used as an antibiotic in animal husbandry. Its implication in cancer therapy has… Continue reading

Effects of Propofol, a Sedative-Hypnotic Drug, on the Lipid Profile, Antioxidant Indices, and Cardiovascular Marker Enzymes in Wistar Rats.

Effects of propofol, a sedative-hypnotic drug, on the lipid profile, antioxidant indices, and cardiovascular marker enzymes in wistar rats.

ISRN Pharmacol. 2013; 2013: 230261
Adaramoye OA, Akinwonmi O, Akanni O

In recent years, the activity of anaesthetic propofol on… Continue reading

Autophagy in Breast Cancer and Its Implications for Therapy.

Autophagy in breast cancer and its implications for therapy.

Am J Cancer Res. 2013; 3(3): 251-65
Jain K, Paranandi KS, Sridharan S, Basu A

Autophagy is an evolutionarily conserved process of cellular self-digestion that serves as a mechanism to… Continue reading

Antidepressant Utilization and Suicide in Europe: An Ecological Multi-National Study.

Antidepressant Utilization and Suicide in Europe: An Ecological Multi-National Study.

PLoS One. 2013; 8(6): e66455
Gusmão R, Quintão S, McDaid D, Arensman E, Van Audenhove C, Coffey C, Värnik A, Värnik P, Coyne J, Hegerl U

Research concerning the… Continue reading

Potential Use of Custirsen to Treat Prostate Cancer.

Potential use of custirsen to treat prostate cancer.

Onco Targets Ther. 2013; 6: 785-97
Higano CS

Over the last few years, five agents have demonstrated a survival benefit over a comparator treatment or placebo in the treatment of metastatic… Continue reading

Spectrum of Depression


 

Spectrum of Depression

 

Evotec to Realign Discovery Chemistry Operations
We operate worldwide providing the highest quality stand-alone and integrated drug discovery solutions, covering all activities from target-to-clinic. The Company has established a unique position by assembling top-class… Continue reading

Scaling and Systems Biology for Integrating Multiple Organs-on-a-Chip.

Scaling and systems biology for integrating multiple organs-on-a-chip.

Lab Chip. 2013 Jul 5;
Wikswo JP, Curtis EL, Eagleton ZE, Evans BC, Kole A, Hofmeister LH, Matloff WJ

Coupled systems of in vitro microfabricated organs-on-a-chip containing small populations of human… Continue reading

Exploring the Ligand-Protein Networks in Traditional Chinese Medicine: Current Databases, Methods, and Applications.

Exploring the ligand-protein networks in traditional chinese medicine: current databases, methods, and applications.

Evid Based Complement Alternat Med. 2013; 2013: 806072
Zhao M, Zhou Q, Ma W, Wei DQ

The traditional Chinese medicine (TCM), which has thousands of years… Continue reading

Comparative Proteomic Analysis of Peritoneal Dialysate From Chronic Glomerulonephritis Patients.

Comparative proteomic analysis of peritoneal dialysate from chronic glomerulonephritis patients.

Biomed Res Int. 2013; 2013: 863860
Wu HY, Liao AC, Huang CC, Liao PC, Chien CC, Kan WC, Wang HY

Peritoneal dialysis (PD) frequently contributes to peritoneal damage which… Continue reading

A Review of Targeted Therapies Evaluated by the Pediatric Preclinical Testing Program for Osteosarcoma.

A review of targeted therapies evaluated by the pediatric preclinical testing program for osteosarcoma.

Front Oncol. 2013; 3: 132
Sampson VB, Gorlick R, Kamara D, Anders Kolb E

Osteosarcoma, the most common malignant bone tumor of childhood, is a… Continue reading