Addiction Rehab: Immunogenicity and Autoimmunity During Anti-TNF Therapy.
Immunogenicity and autoimmunity during anti-TNF therapy.
Filed under: Addiction Rehab
Autoimmun Rev. 2012 Nov 30;
Atzeni F, Talotta R, Benucci M, Salaffi F, Cassinotti A, Varisco V, Battellino M, Ardizzone S, Pace F, Sarzi-Puttini P
The introduction of anti-TNF… Continue reading
Canada Clamps Down on Access to Drug Safety Data.
Canada clamps down on access to drug safety data.
Filed under: Drug and Alcohol Rehabilitation
Lancet. 2012 Nov 24; 380(9856): 1805
Webster PC
Spinosad: An effective and safe pediculicide.
Filed under: Drug and Alcohol Rehabilitation… Continue reading
Role of Reactive Oxygen Species in the Synergistic Cytotoxicity of Safingol-Based Combination Regimens With Conventional Chemotherapeutics.
Role of reactive oxygen species in the synergistic cytotoxicity of safingol-based combination regimens with conventional chemotherapeutics.
Filed under: Drug and Alcohol Rehabilitation
Oncol Lett. 2011 Sep 1; 2(5): 905-910
Ling LU, Tan KB, Chiu GN
Exploiting the sensitivity of cancer cells to reactive oxygen species (ROS) has been suggested as a strategy for the selective elimination of cancer cells. In this study, the ROS-generating sphingolipid safingol was combined with various conventional chemotherapeutics, and the potential synergism of the safingol-based combination regimen was assessed using a panel of cancer cell lines. The IC(50) values of safingol using as a single agent were 1.4-6.3 µM, which are concentrations that are clinically achievable. While synergism was dependent on the drug molar ratios, a 4:1 molar ratio of safingol to conventional chemotherapeutics exhibited a moderate to strong synergism in MDA-MB-231, JIMT-1, SKOV-3, U937 and KB cells, with combination indices ranging from 0.07 to 0.77. Furthermore, the addition of safingol may reduce the concentrations of conventional chemotherapeutics required to achieve 90% cell-kill by 1 to >3 log-folds. A significant… Continue reading