Clinical trial

Analysis of Novel Melphalan Hydrolysis Products Formed Under Isolated Lung Perfusion Conditions Using Liquid Chromatography/tandem Mass Spectrometry.

Published March 16, 2013

Analysis of novel melphalan hydrolysis products formed under isolated lung perfusion conditions using liquid chromatography/tandem mass spectrometry.

Rapid Commun Mass Spectrom. 2013 Apr 15; 27(7): 835-841
Boschmans J, de Bruijn E, Van Schil P, Lemière F

RATIONALE: Melphalan is a widely used cytotoxic agent in cancer treatments. This phenylalanine analog has been shown an effective drug in the treatment of breast cancer, multiple myeloma and melanoma of the extremities. A good knowledge of the drug’s degradation and metabolism are crucial for understanding its activity during cancer treatments. METHODS: The formation of hydrolysis products of melphalan is studied using ultra-performance liquid chromatography (UPLC) tandem mass spectrometry (MS/MS). Aqueous melphalan solutions were incubated at elevated temperatures and analyzed by UPLC/MS/MS. Two previously described hydrolysis products, mono- and dihydroxymelphalan (MOH and DOH), were formed in vitro and could be characterized during MS/MS and high-resolution experiments. RESULTS: Novel compounds with m/z values >500?Da were discovered.… Continue reading →

Interaction of Neuropeptide Y Genotype and Childhood Emotional Maltreatment on Brain Activity During Emotional Processing.

Published March 15, 2013

Interaction of neuropeptide Y genotype and childhood emotional maltreatment on brain activity during emotional processing.

Soc Cogn Affect Neurosci. 2013 Mar 11;
Opmeer EM, Kortekaas R, van Tol MJ, van der Wee NJ, Woudstra S, van Buchem MA, Penninx… Continue reading →

Weak Affinity Chromatography for Evaluation of Stereoisomers in Early Drug Discovery.

Published March 13, 2013

Weak Affinity Chromatography for Evaluation of Stereoisomers in Early Drug Discovery.

J Biomol Screen. 2013 Mar 11;
Duong-Thi MD, Bergström M, Fex T, Svensson S, Ohlson S, Isaksson R

In early drug discovery (e.g., in fragment screening), recognition of… Continue reading →

Closing the Door to Human Immunodeficiency Virus.

Published March 13, 2013

Closing the door to human immunodeficiency virus.

Protein Cell. 2013 Feb; 4(2): 86-102
Kang Y, Guo J, Chen Z

The pandemic of human immunodeficiency virus type one (HIV-1), the major etiologic agent of acquired immunodeficiency disease (AIDS), has led… Continue reading →

Blood Gases and Energy Metabolites in Mouse Blood Before and After Cerebral Ischemia: The Effects of Anesthetics.

Published March 13, 2013

Blood gases and energy metabolites in mouse blood before and after cerebral ischemia: the effects of anesthetics.

Exp Biol Med (Maywood). 2013 Jan 1; 238(1): 84-9
Schwarzkopf TM, Horn T, Lang D, Klein J

The levels of blood gases… Continue reading →

Livestock-Associated Staphylococcus Aureus CC398: Animal Reservoirs and Human Infections.

Published March 12, 2013

Livestock-associated Staphylococcus aureus CC398: animal reservoirs and human infections.

Infect Genet Evol. 2013 Mar 5;
Verkade E, Kluytmans J

Over the past 15 years the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) has changed significantly. Being initially a nosocomial pathogen,… Continue reading →

Duloxetine and Pregnancy Outcomes: Safety Surveillance Findings.

Published March 9, 2013

Duloxetine and pregnancy outcomes: safety surveillance findings.

Int J Med Sci. 2013; 10(4): 413-9
Hoog SL, Cheng Y, Elpers J, Dowsett SA

Duloxetine hydrochloride is approved for the treatment or management of major depressive disorder, generalized anxiety disorder, diabetic… Continue reading →

Recovery Mechanisms of Somatosensory Function in Stroke Patients: Implications of Brain Imaging Studies.

Published March 9, 2013

Recovery mechanisms of somatosensory function in stroke patients: implications of brain imaging studies.

Neurosci Bull. 2013 Mar 8;
Jang SH

Somatosensory dysfunction is associated with a high incidence of functional impairment and safety in patients with stroke. With developments… Continue reading →

Fat to Treat Fat: Emerging Relationship Between Dietary PUFA, Endocannabinoids, and Obesity.

Published March 8, 2013

Fat to treat fat: Emerging relationship between dietary PUFA, endocannabinoids, and obesity.

Prostaglandins Other Lipid Mediat. 2013 Mar 1;
Kim J, Li Y, Watkins BA

Obesity incidence continues to escalate as a global nutrition and health problem. Scientists and… Continue reading →

Walking Performance: Correlation Between Energy Cost of Walking and Walking Participation. New Statistical Approach Concerning Outcome Measurement.

Published March 8, 2013

Walking Performance: Correlation between Energy Cost of Walking and Walking Participation. New Statistical Approach Concerning Outcome Measurement.

PLoS One. 2013; 8(2): e56669
Franceschini M, Rampello A, Agosti M, Massucci M, Bovolenta F, Sale P

Walking ability, though important for… Continue reading →

Analysis of Novel Melphalan Hydrolysis Products Formed Under Isolated Lung Perfusion Conditions Using Liquid Chromatography/tandem Mass Spectrometry.

Interaction of Neuropeptide Y Genotype and Childhood Emotional Maltreatment on Brain Activity During Emotional Processing.

Weak Affinity Chromatography for Evaluation of Stereoisomers in Early Drug Discovery.

Closing the Door to Human Immunodeficiency Virus.

Blood Gases and Energy Metabolites in Mouse Blood Before and After Cerebral Ischemia: The Effects of Anesthetics.

Livestock-Associated Staphylococcus Aureus CC398: Animal Reservoirs and Human Infections.

Duloxetine and Pregnancy Outcomes: Safety Surveillance Findings.

Recovery Mechanisms of Somatosensory Function in Stroke Patients: Implications of Brain Imaging Studies.

Fat to Treat Fat: Emerging Relationship Between Dietary PUFA, Endocannabinoids, and Obesity.

Walking Performance: Correlation Between Energy Cost of Walking and Walking Participation. New Statistical Approach Concerning Outcome Measurement.

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