Susceptibility Genes Are Enriched in Those of the HSV-1/host Interactome in Psychiatric and Neurological Disorders.
Susceptibility genes are enriched in those of the HSV-1/host interactome in psychiatric and neurological disorders.
Pathog Dis. 2013 Aug 3;
Carter CJ
Herpes simplex (HSV-1) can promote beta-amyloid deposition and tau phosphorylation, demyelination or cognitive deficits relevant to Alzheimer’s disease or multiple sclerosis and to many neuropsychiatric disorders with which it has been implicated. A seroprevalence much higher than disease incidence has called into question any primary causal role. However, as also the case with risk promoting polymorphisms, (also present in control populations) any causal effects are likely to be conditional. During its life cycle, the virus binds to many proteins and modifies the expression of multiple genes creating a host/pathogen interactome involving 1347 host genes. This dataset is heavily enriched in the susceptibility genes for multiple sclerosis (P= 1.3E-99) >Alzheimer’s disease > schizophrenia > Parkinsonism > depression> bipolar disorder> childhood obesity> chronic fatigue> autism > and anorexia (P=0.047) but not ADHD, a relationship maintained for GWAS datasets in multiple sclerosis and Alzheimer’s… Continue reading
[Functional and Aesthetic Rehabilitation of Microtia in Children and Adolescents].
[Functional and aesthetic rehabilitation of microtia in children and adolescents].
HNO. 2013 Aug; 61(8): 655-61
Hempel JM, Braun T, Berghaus A
Microtia leads to a severe functional and aesthetic handicap. Traditionally, the auricle is often reconstructed with cartilage transplants,… Continue reading
Evaluation of Persistence and Adherence to Teriparatide Treatment in Patients Affected by Severe Osteoporosis (PATT): A Multicenter Observational Real Life Study.
Evaluation of persistence and adherence to teriparatide treatment in patients affected by severe osteoporosis (PATT): a multicenter observational real life study.
Clin Cases Miner Bone Metab. 2013 Jan; 10(1): 56-60
Migliaccio S, Resmini G, Buffa A, Fornari R, Di… Continue reading
The Role of Attention to Emotion in Recovery From Major Depressive Disorder.
The Role of Attention to Emotion in Recovery from Major Depressive Disorder.
Depress Res Treat. 2013; 2013: 540726
Thompson RJ, Mata J, Jaeggi SM, Buschkuehl M, Jonides J, Gotlib IH
Major Depressive Disorder (MDD) is characterized by several emotional… Continue reading
Aspen Plus(®) and Economic Modeling of Equine Waste Utilization For Localized Hot Water Heating via Fast Pyrolysis.
Aspen Plus(®) and economic modeling of equine waste utilization for localized hot water heating via fast pyrolysis.
J Environ Manage. 2013 Jul 8; 128C: 594-601
Hammer NL, Boateng AA, Mullen CA, Wheeler MC
Aspen Plus(®) based simulation models… Continue reading
Association Between Plasma Brain-Derived Neurotrophic Factor Levels and Personality Traits in Healthy Japanese Subjects.
Association between plasma brain-derived neurotrophic factor levels and personality traits in healthy Japanese subjects.
Psychiatry Res. 2013 Jun 24;
Yasui-Furukori N, Tsuchimine S, Kaneda A, Sugawara N, Ishioka M, Kaneko S
Although depression has been associated with decreased brain-derived… Continue reading
Perioperative Analgesia in Pediatric Surgery.
Perioperative analgesia in pediatric surgery.
Curr Opin Anaesthesiol. 2013 Jun 10;
Russell P, von Ungern-Sternberg BS, Schug SA
PURPOSE OF REVIEW: Poor pain management has continued to be a problem after pediatric surgery. This review examines the current situation… Continue reading
Reducing Racial/Ethnic Disparities in Childhood Obesity: The Role of Early Life Risk Factors.
Reducing Racial/Ethnic Disparities in Childhood Obesity: The Role of Early Life Risk Factors.
JAMA Pediatr. 2013 Jun 3; 1-7
Taveras EM, Gillman MW, Kleinman KP, Rich-Edwards JW, Rifas-Shiman SL
IMPORTANCE Many early life risk factors for childhood obesity are… Continue reading