Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids.
Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids.
Chem Sci. 2013 Apr 1; 4(4): 1646-1657
Boyer N, Morrison KC, Kim J, Hergenrother PJ, Movassaghi M
The epipolythiodiketopiperazine (ETP) alkaloids are a highly complex class of natural products with potent anticancer… Continue reading
Identifying Depression, Some of the Symptoms of Depression
Identifying Depression, Some of the Symptoms of Depression
Counselor Greg Samples, from “A Growth Place” instructs on how one can identify depression or to identify symptoms of depression. A Growth Place is in the At…
6 Exercises to… Continue reading
Is Sulphadoxine-Pyrimethamine (SP) Still Useful as the First-Line Antimalarial Drug in Malawi or It Must Be Quickly Withdrawn From the Antimalarial Repertoire?
Is sulphadoxine-pyrimethamine (SP) still useful as the first-line antimalarial drug in Malawi or it must be quickly withdrawn from the antimalarial repertoire?
Malawi Med J. 2007 Mar; 19(1): 37-8
Nkhoma S
Application of design of experiment… Continue reading
Her2 Activation Mechanism Reflects Evolutionary Preservation of Asymmetric Ectodomain Dimers in the Human EGFR Family.
Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family.
Elife. 2013; 2: e00708
Arkhipov A, Shan Y, Kim ET, Dror RO, Shaw DE
The receptor tyrosine kinase Her2, an intensely pursued drug target,… Continue reading
Mefloquine Use, Psychosis, and Violence: A Retinoid Toxicity Hypothesis.
Mefloquine use, psychosis, and violence: A retinoid toxicity hypothesis.
Med Sci Monit. 2013; 19: 579-83
Mawson A
Mefloquine use has been linked to severe gastrointestinal and neuropsychiatric adverse effects, including cognitive disturbances, anxiety, depression, psychosis, and violence. The adverse… Continue reading
Effects of Propofol, a Sedative-Hypnotic Drug, on the Lipid Profile, Antioxidant Indices, and Cardiovascular Marker Enzymes in Wistar Rats.
Effects of propofol, a sedative-hypnotic drug, on the lipid profile, antioxidant indices, and cardiovascular marker enzymes in wistar rats.
ISRN Pharmacol. 2013; 2013: 230261
Adaramoye OA, Akinwonmi O, Akanni O
In recent years, the activity of anaesthetic propofol on… Continue reading
Metformin Increases Mitochondrial Energy Formation in L6 Muscle Cell Cultures.
Metformin Increases Mitochondrial Energy Formation in L6 Muscle Cell Cultures.
J Biol Chem. 2013 May 29;
Vytla VS, Ochs RS
A popular hypothesis for the action of metformin, the widely used anti-diabetes drug, is the inhibition of mitochondrial respiration,… Continue reading
[Ibuprofen: Safety and Efficiency of Its Use in Wide Clinical Practice].
[Ibuprofen: safety and efficiency of its use in wide clinical practice].
Ter Arkh. 2013; 85(3): 118-24
The paper presents data on the pharmacokinetics of the nonsteroidal anti-inflammatory drug ibuprofen and a review of the evidence base that suggests its… Continue reading
Pharmacophore Modeling and 3D Quantitative Structure-Activity Relationship Analysis of Febrifugine Analogues as Potent Antimalarial Agent.
Pharmacophore modeling and 3D quantitative structure-activity relationship analysis of febrifugine analogues as potent antimalarial agent.
J Adv Pharm Technol Res. 2013 Jan; 4(1): 50-60
Sen D, Chatterjee TK
Febrifugine and its derivatives are effective against Plasmodium falciparum. Using PHASE… Continue reading