Three-Dimensional Gait Analysis Can Shed New Light on Walking in Patients With Haemophilia.

Three-dimensional gait analysis can shed new light on walking in patients with haemophilia.

ScientificWorldJournal. 2013; 2013: 284358
Lobet S, Detrembleur C, Massaad F, Hermans C

In patients with haemophilia (PWH) (from Greek “blood love”), the long-term consequences of repeated haemarthrosis include cartilage damage and irreversible arthropathy, resulting in severe impairments in locomotion. Quantifying the extent of joint damage is therefore important in order to prevent disease progression and compare the efficacy of treatment strategies. Musculoskeletal impairments in PWH may stem from structural and functional abnormalities, which have traditionally been evaluated radiologically or clinically. However, these examinations are performed in a supine position (i.e., non-weight-bearing condition). We therefore suggest three-dimensional gait analysis (3DGA) as an innovative approach designed to focus on the functional component of the joint during the act of walking. This is of the utmost importance, as pain induced by weight-bearing activities influences the functional performance of the arthropathic joints significantly. This review endeavors to improve our knowledge of the biomechanical consequences of multiple arthropathies on gait pattern in adult patients with haemophilia using 3DGA. In PWH with arthropathy, the more the joint function was altered, the more the metabolic energy was consumed. 3DGA analysis could highlight the effect of an orthopedic disorder in PWH during walking. Indeed, mechanical and metabolic impairments were correlated to the progressive loss of active mobility into the joints. HubMed – rehab


Evaluation of a computer-assisted errorless learning-based memory training program for patients with early Alzheimer’s disease in Hong Kong: a pilot study.

Clin Interv Aging. 2013; 8: 623-33
Lee GY, Yip CC, Yu EC, Man DW

Improving the situation in older adults with cognitive decline and evidence of cognitive rehabilitation is considered crucial in long-term care of the elderly. The objective of this study was to implement a computerized errorless learning-based memory training program (CELP) for persons with early Alzheimer’s disease, and to compare the training outcomes of a CELP group with those of a therapist-led errorless learning program (TELP) group and a waiting-list control group.A randomized controlled trial with a single-blind research design was used in the study. Chinese patients with early Alzheimer’s disease screened by the Clinical Dementia Rating (score of 1) were recruited. The subjects were randomly assigned to CELP (n = 6), TELP (n = 6), and waiting-list control (n = 7) groups. Evaluation of subjects before and after testing, and at three-month follow-up was achieved using primary outcomes on the Chinese Mini-Mental State Examination, Chinese Dementia Rating Scale, Hong Kong List Learning Test, and the Brief Assessment of Prospective Memory-Short Form. Secondary outcomes were the Modified Barthel Index, Hong Kong Lawton Instrumental Activities of Daily Living Scale, and Geriatric Depression Scale-Short Form. The data were analyzed using Friedman’s test for time effect and the Kruskal-Wallis test for treatment effect.Positive treatment effects on cognition were found in two errorless learning-based memory groups (ie, computer-assisted and therapist-led). Remarkable changes were shown in cognitive function for subjects receiving CELP and emotional/daily functions in those receiving TELP.Positive changes in the cognitive function of Chinese patients with early Alzheimer’s disease were initially found after errorless training through CELP. Further enhancement of the training program is recommended. HubMed – rehab


Photobiomodulation of surgical wound dehiscence in a diabetic individual by low-level laser therapy following median sternotomy.

Indian J Palliat Care. 2013 Jan; 19(1): 71-5
Dixit S, Maiya A, Umakanth S, Borkar S

In this single case study, we attempt to outline the possible effect of low-level laser therapy (LLLT) on delayed wound healing and pain in chronic dehiscent sternotomy of a diabetic individual. The methods that were employed to evaluate changes pre and post irradiation were wound photography, wound area measurement, pressure ulcer scale of healing (PUSH), and visual analogue scale (VAS) for pain. After irradiation, proliferation of healthy granulation tissue was observed with decrease in scores of PUSH for sternal dehiscence and VAS for bilateral shoulders and sternal dehiscence. We found that LLLT irradiation could be a novel method of treatment for chronic sternal dehiscence following coronary artery bypass grafting, as it augments wound healing with an early closure of the wound deficit. Hence, this might be translated into an early functional rehabilitation and decreased pain perception of an individual following surgical complication. HubMed – rehab


A palliative approach for rehabilitation of a pediatric patient with retinoblastoma.

Indian J Palliat Care. 2013 Jan; 19(1): 67-70
Aggarwal H, Kumar P, Singh RD, Gupta SK

Retinoblastoma is a highly malignant neoplasm. Most of the cases are usually far advanced at the time of detection, requiring enucleation to salvage the child’s life. However, the cosmetic rehabilitation of these patients should always be an integral part of their treatment, which helps in their re-integration in the society. This paper presents a case of 5-year-old patient who had undergone enucleation of her left eye due to retinoblastoma. A multidisciplinary approach, including ophthalmologist, psychotherapist, and a prosthodontist, was adopted to meet her physical, psychological, functional, emotional, social, and cosmetic demands. The patient was rehabilitated cosmetically with precisely fabricated ocular prosthesis. An ocular prosthesis is a highly positive and non-invasive approach to improve the cosmetic appearance and psychological well-being of patient. HubMed – rehab



J Pharmacol Exp Ther. 2013 Jun 13;
Calzetta L, Spina D, Page C, Rogliani P, Facciolo F, Cazzola M, Matera MG

The phosphodiesterase (PDE) enzyme family hydrolyse cAMP and cGMP, second messengers that regulate a variety of cellular processes, including airway smooth muscle (ASM) relaxation and the inhibition of inflammatory cells. We have investigated the activity of RPL554, a dual PDE3/PDE4 inhibitor exhibiting bifunctional activity for its effects on the tone of human isolated ASM, and any potential synergistic interactions with muscarinic receptor antagonists or a ?2-agonist. We evaluated the influence of RPL554 on the contractile response induced by electrical field stimulation (EFS), acetylcholine (ACh) or histamine on human isolated bronchi. We have also analysed the potential synergistic effect of RPL554 in combination with either atropine, glycopyrollate or salbutamol by using Berenbaum, Bliss Independence (BI) or the dose equivalence methods. RPL554 inhibited the contraction induced by EFS (Emax-91.33±3.37%, P<0.001), relaxed bronchi pre-contracted with ACh (Emax-94.62±2.63%, pD2 4.84±0.12, P<0.001) and abolished the contraction induced by histamine. The analysis of interaction indicated a weak synergism between RPL554 and salbutamol (Interaction Index: 0.25±0.06; BI delta-effect: 0.29±0.11; dose equivalence: no synergism), but significant synergism between RPL554 and atropine (Interaction Index: 0.09±0.07; BI delta-effect: 0.54±0.09; dose equivalence: synergism for low concentrations) or glycopyrrolate (ACh: BI delta-effect 0.46±0.03, Berenbaum delta-effect 0.42±0.02; histamine: BI delta effect 0.46±0.03, Berenbaum delta effect 0.42±0.03). This study demonstrates that RPL554 relaxes human bronchi and that it can interact with a muscarinic receptor antagonist to produce a synergistic inhibition of ASM tone. These results suggest that RPL554 may provide a novel treatment for airway diseases, either alone or in combination with anti-muscarinic drugs. HubMed – rehab



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