Therapeutic Monitoring of Psychoactive Drugs – Antidepressants: A Review.

Therapeutic monitoring of psychoactive drugs – antidepressants: A review.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013 Mar 21;
Grundmann M, Kacirova I, Urinovska R

BACKGROUND: Major depression, is one of the most prevalent mental disorders in Europe and the USA. The dramatic rise in pharmacological antidepressants is mainly due to increase in use of selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors and other new generation antidepressants. In clinical practice, optimum individual doses are often guided by trial-and-error. This article reviews the available literature on therapeutic monitoring of antidepressant drugs. METHODS: A search using MEDLINE (english-language reports, 1983 – August 2012) with the key words for antidepressant drugs and therapeutic drug monitoring. RESULTS: There is a need for monitoring antidepressants due to wide interindividual pharmacokinetic variability. At the same drug dose, a more than 20-fold variation in steady state concentration of drug in the body may result: people differ in their ability to absorb, distribute, metabolise and excrete drugs for reasons of concurrent disease, age, gender, smoking and eating habits, concomitant medication and genetics. CONCLUSIONS: Monitoring of antidepressant drugs enables us to individualise drug doses based on rational therapy, minimalise side effects, reduce morbidity and mortality and cut the cost of health care. Phenotyping and genotyping could increase therapeutic drug monitoring furthere. HubMed – eating


Emotion-Focused Therapy and Dietary Counseling for Obese Patients with Binge Eating Disorder: A Propensity Score-Adjusted Study.

Psychother Psychosom. 2013 Mar 28; 82(3): 193-194
Compare A, Calugi S, Marchesini G, Molinari E, Dalle Grave R

HubMed – eating


Topiramate for abnormal eating behaviour in frontotemporal dementia.

Behav Neurol. 2013 Apr 2;
Singam C, Walterfang M, Mocellin R, Evans A, Velakoulis D

Topiramate is a sulfamate-substituted monosaccharide anticonvulsant that is associated with anorexia and weight loss and has been used to treat binge eating disorder and bulimia nervosa. This report describes a man with frontotemporal dementia, behavioural variant, associated with abnormal eating behaviour which appeared to respond to topiramate. We review the physiological basis of abnormal eating behaviour in frontotemporal dementia and explore possible mechanisms of action by which topiramate may modify eating behaviour in this condition. HubMed – eating


Does Mindfulness Matter? Everyday mindfulness, mindful eating and self-reported serving size of energy dense foods among a sample of South Australian Adults.

Appetite. 2013 Mar 30;
Beshara M, Hutchinson AD, Wilson C

Serving size is a modifiable determinant of energy consumption, and an important factor to address in the prevention and treatment of obesity. The present study tested an hypothesised negative association between individuals’ everyday mindfulness and self-reported serving size of energy dense foods. The mediating role of mindful eating was also explored. A community sample of 171 South Australian adults completed self-report measures of everyday mindfulness and mindful eating. The dependent measure was participants’ self-reported average serving size of energy dense foods consumed in the preceding week. Participants who reported higher levels of everyday mindfulness were more mindful eaters (r = 0.41, p <0.05) and reported smaller serving size estimates of energy dense foods (r = -.25, p <0.05). Mindful eating fully mediated the negative association between everyday mindfulness and serving size. The domains of mindful eating most relevant to serving size included emotional and disinhibited eating. Results suggest that mindful eating may have a greater influence on serving size than daily mindfulness. HubMed – eating



BHS Eating Disorders Documentary – I did not create this video, all credit goes to Tracey Hayes for all the research and interviewing. I am just uploading it for her. This video is meant to ex…