Therapeutic Approach Targeting TRP Channels and Development of Anti-Aspiration Drugs.

Therapeutic approach targeting TRP channels and development of anti-aspiration drugs.

Filed under: Eating Disorders

Rinsho Shinkeigaku. 2012; 52(11): 1195-7
Ebihara S

Aspiration pneumonia is a major health problem in the elderly. A swallowing disorder, such as a delayed triggering of the swallowing reflex, predisposes in patients with aspiration pneumonia. Swallowing reflex was delayed when the temperature of the food is close to body temperature. The actual swallowing time shortened when the temperature difference increases. The improvement of swallowing reflex by temperature stimuli could be mediated by the temperature-sensitive TRP channel at pharynx. The administration of capsaicin as an agonist stimulus of TRPV1, a warm temperature receptor, decreased the delay in swallowing reflex. Food with menthol, agonist of TRPM8 which is a cold temperature receptor, also decreased the delay in swallowing reflex. Olfactory stimulation such as black pepper was useful to improve the swallowing reflex for people with low ADL levels or with decreased consciousness. Thus, we found anti-aspiration drugs with various site of actions on the hierarchical structure of neuronal control of swallowing. By combining anti-aspiration drugs and swallowing rehabilitations, we developed a protocol to start eating more efficiently and safely. Implementation of this protocol would help avoid re-aspiration in many elderly people with aspiration pneumonia. The combination of various anti-aspiration drugs may improve the swallowing disorders and prevent aspiration pneumonia.
HubMed – eating


The role of interpersonal functioning in the maintenance of eating psychopathology: A systematic review and testable model.

Filed under: Eating Disorders

Clin Psychol Rev. 2012 Nov 10; 33(1): 156-167
Arcelus J, Haslam M, Farrow C, Meyer C

This review aims to systematically evaluate the empirical literature relating to the interpersonal functioning of those with eating disorder psychopathology and presents a preliminary model to help the formulation of patients’ problems. Following a thorough literature search, 35 papers were included in this systematic review. The vast majority of studies indicate a strong association between eating psychopathology and certain maladaptive personality traits. The origins of social anxiety and poor social support that have been described as maintaining eating disorders appear to differ according to diagnostic groups. Interpersonal difficulties in people with restrictive behaviors such as anorexia appear to be related to the avoidance of expressing feelings to others and to giving priority to other people’s feeling over their own. While interpersonal difficulties in patients with bulimia nervosa appear to be more related to interpersonal distrust and negative interaction and conflict with others. These concepts are presented in a preliminary model of interpersonal functioning in the eating disorders.
HubMed – eating


Skilled motor control for the preclinical assessment of functional deficits and recovery following nigral and striatal cell transplantation.

Filed under: Eating Disorders

Prog Brain Res. 2012; 200: 279-301
Klein A, Whishaw IQ

Neural transplantation holds the promise for restoring behavioral function following brain injury. Substantial evidence indicates that fetal neurons transplanted to the adult brain survive and incorporate into remaining neural tissue and produce positive behavioral effects. A yet-unanswered question is whether the integration of new tissue can restore complex neural circuits that connect the neocortex, basal ganglia, and brainstem, and restore functions that are mediated by these circuits. This chapter describes the skilled reaching task, a task that requires transport of the arm and hand to grasp a food item and withdrawal to place the food item in the mouth for eating. It is a movement that is readily expressed in rodents and is fundamental to both nonhuman primates and humans. Methods for analyzing skilled reaching have been developed for preclinical rodent and mouse models of Parkinson’s disease and Huntington’s disease that are generalizable to humans with those clinical disorders. It is suggested that the task provides a motor benchmark for assessing the restoration of function produced by neural transplantation.
HubMed – eating



Eating Disorders and the Media – My English class final. How the media has an effect on body image.


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