The Role of Galanin System in Modulating Depression, Anxiety, and Addiction-Like Behaviors After Chronic Restraint Stress.
... antidepressant, fluoxetine, normalized the CRS-induced behavioral changes based on reversing the higher expression of galanin and TH while increasing the expression of GalR2 and ?2A-adrenceptor. These results indicate that activating the galanin system, with corresponding changes to noradrenergic systems,… Continue reading
Application of Liposomes in Drug Development – Focus on Gastroenterological Targets.
... – focus on gastroenterological targets. Int J Nanomedicine. 2013; 8: 1325-34Zhang JX, Wang K, Mao ZF, Fan X, Jiang DL, Chen M, Cui L, Sun K, Dang SC Over the past decade, liposomes became a focal point in developing… Continue reading
Restorative Therapies to Enhance Sensorimotor Recovery Following Cerebral Ischemia.
... J The development of therapies that aim to facilitate functional recovery has identified potential approaches in stroke research. The main advantage of restorative therapies is their delayed administration after acute necrotic cell death, when the treatment can be combined… Continue reading
Defining a Service for People Who Use Drugs as ‘low-threshold’: What Should Be the Criteria?
... KM, Pettinati HM, Oslin DW, O’Brien CP, Ferraro TN, Doyle GA, Lohoff FW, Berrettini WH The opioid receptor family is involved in the development and maintenance of drug addiction. The mu-opioid receptor (MOR) mediates the rewarding effects of multiple… Continue reading
Addiction Rehab: Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders.
... inhibition of CaMKII activity produced a long-lasting reversal of the increased GluA1 S831 phosphorylation levels in NAcc shell and persistently blocked the enhanced locomotor response to and self-administration of amphetamine normally observed in rats previously exposed to the drug.… Continue reading
Assessing the Co-Occurring Capability of Mental Health Treatment Programs: The Dual Diagnosis Capability in Mental Health Treatment (DDCMHT) Index.
... resistance remains an important problem. Genomic profiling has demonstrated that ERBB2+ve breast cancers are distinguished from ER+ve and ‘triple-negative’ breast cancers by harbouring not only the ERBB2 amplification on 17q12, but also a number of co-amplified genes on 17q12… Continue reading
Depression Treatment: Revisiting Serotonin Reuptake Inhibitors and the Therapeutic Potential of “Uptake-2” in Psychiatric Disorders.
... transporter (SERT). However, the relative lack of therapeutic efficacy of SSRIs has brought into question the utility of increasing extracellular serotonin for the treatment of depression. In this Viewpoint, we discuss why increasing extracellular serotonin should not be written… Continue reading