Mouse Model

Has the Drug GRN-29 Improved Autism Symptoms in Mice?

Question by Kevin7: has the drug GRN-29 improved autism symptoms in mice?

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Best answer:

Answer by H????? ?oi 416™
*GRN-529

Agent Reduces Autism-Like Behaviors in Mice: Boosts Sociability, Quells Repetitiveness

ScienceDaily (Apr. 25, 2012) — National Institutes… Continue reading

Molecular Distribution of Amino Acid Substitutions on Neuraminidase From the 2009 (H1N1) Human Influenza Pandemic Virus.

Molecular distribution of amino acid substitutions on neuraminidase from the 2009 (H1N1) human influenza pandemic virus.

Bioinformation. 2013; 9(13): 673-9
Quiliano M, Valdivia-Olarte H, Olivares C, Requena D, Gutiérrez AH, Reyes-Loyola P, Tolentino-Lopez LE, Sheen P, Briz V, Muñoz-Fernández… Continue reading

OLANZAPINE ACTIVATES HEPATIC MAMMALIAN TARGET of RAPAMYCIN (MTOR): NEW MECHANISTIC INSIGHT INTO METABOLIC DYSREGULATION WITH ATYPICAL ANTIPSYCHOTIC DRUGS.

OLANZAPINE ACTIVATES HEPATIC MAMMALIAN TARGET OF RAPAMYCIN (mTOR): NEW MECHANISTIC INSIGHT INTO METABOLIC DYSREGULATION WITH ATYPICAL ANTIPSYCHOTIC DRUGS.

J Pharmacol Exp Ther. 2013 Aug 7;
Schmidt RH, Jokinen JD, Massey VL, Falkner KC, Shi X, Yin X, Zhang X,… Continue reading

SAHA Enhances Synaptic Function and Plasticity in Vitro but Has Limited Brain Availability in Vivo and Does Not Impact Cognition.

SAHA Enhances Synaptic Function and Plasticity In Vitro but Has Limited Brain Availability In Vivo and Does Not Impact Cognition.

PLoS One. 2013; 8(7): e69964
Hanson JE, La H, Plise E, Chen YH, Ding X, Hanania T, Sabath EV,… Continue reading

Poisoning With Depilatory Agents in Iran.

Poisoning with depilatory agents in Iran.

J Res Med Sci. 2013 Feb; 18(2): 168-9
Mehrpour O, Farzaneh E, Hasanian-Moghaddam H, Abdollahi A, Rayesson MR, Abdollahi M

HubMed – addiction

Addiction is a Reward Deficit and Stress Surfeit Disorder.

Front… Continue reading

Unintentional Weakness of Cancers: The MEK/ERK Pathway as a Double-Edged Sword.

Unintentional weakness of cancers: the MEK/ERK pathway as a double-edged sword.

Mol Cancer Res. 2013 Jul 30;
Suda K, Mitsudomi T

Recent advances in molecular target therapy have greatly improved treatment outcomes for cancers driven by oncogenic mutations. However… Continue reading

Mechanisms of Resistance to Sorafenib and the Corresponding Strategies in Hepatocellular Carcinoma.

Mechanisms of resistance to sorafenib and the corresponding strategies in hepatocellular carcinoma.

World J Hepatol. 2013 Jul 27; 5(7): 345-52
Zhai B, Sun XY

Sorafenib, the unique drug as first-line treatment for advanced hepatocellular carcinoma (HCC), has opened a… Continue reading

The Pharmacists’ Potential to Provide Targets for Interventions to Optimize Pharmacotherapy in Patients With Asthma.

The pharmacists’ potential to provide targets for interventions to optimize pharmacotherapy in patients with asthma.

Int J Clin Pharm. 2013 Jul 26;
van Boven JF, Hiddink EG, Stuurman-Bieze AG, Schuiling-Veninga CC, Postma MJ, Vegter S

Background Despite of pharmacists’ specialized knowledge of medication and his/her regular contact with patients, the expertise of the pharmacist may not be used enough yet. Furthermore, the potential of pharmacy dispensing data is underestimated. Objective To provide targets for tailored interventions in asthma patients and to illustrate the potential value of pharmacists in the identification of these targets using individual pharmacy dispensing data. Setting We performed a cross sectional retrospective analysis assessing the quality of asthma patients’ pharmacotherapeutic treatment. Method Drug dispensing data from 2008 to 2009 were retrieved from a Dutch pharmacy database. All asthma patients were screened for potential suboptimal pharmacotherapy in 2009. Results were projected to a single community pharmacy to provide an estimate of the number of patients eligible for potential interventions. Main outcome measures (1) frequent use of short-acting ?-agonists without preventive medication, (2) concomitant use of ?-blockers, (3) multiple short courses of oral corticosteroids without using inhaled corticosteroids and 4) use of long-acting ?-agonist without inhaled corticosteroids. Results A total of 8,504 patients were eligible for analysis of the quality of their asthma treatment. 20.9 % of all asthma patients used >100 DDD short-acting ?-agonists… Continue reading

Effect of DA-9701 on Gastric Emptying in a Mouse Model: Assessment by (13)C-Octanoic Acid Breath Test.

Effect of DA-9701 on gastric emptying in a mouse model: Assessment by (13)C-octanoic acid breath test.

World J Gastroenterol. 2013 Jul 21; 19(27): 4380-5
Lim CH, Choi MG, Park H, Baeg MK, Park JM

To evaluate the effects of DA-9701 on the gastric emptying of a solid meal using the (13)C-octanoic acid breath test in a mouse model.Male C57BL/6 mice aged > 8 wk and with body… Continue reading

Plurigon: Three Dimensional Visualization and Classification of High-Dimensionality Data.

Plurigon: three dimensional visualization and classification of high-dimensionality data.

Front Physiol. 2013; 4: 190
Martin B, Chen H, Daimon CM, Chadwick W, Siddiqui S, Maudsley S

High-dimensionality data is rapidly becoming the norm for biomedical sciences and many other… Continue reading