Enhanced Bactericidal Potency of Nanoliposomes by Modification of the Fusion Activity Between Liposomes and Bacterium.
... lipid, DOPE, is included. Regardless of changes in liposome composition, fluid liposomes-bacterium fusion is universally enhanced by calcium ions. The information obtained in this study will increase our understanding of fluid liposomal action mechanisms, and help in optimizing the… Continue reading
Therapeutic Action of Fluoxetine Is Associated With a Reduction in Prefrontal Cortical miR-1971 Expression Levels in a Mouse Model of Posttraumatic Stress Disorder.
... Action of Fluoxetine is Associated with a Reduction in Prefrontal Cortical miR-1971 Expression Levels in a Mouse Model of Posttraumatic Stress Disorder. Front Psychiatry. 2013; 4: 66Schmidt U, Herrmann L, Hagl K, Novak B, Huber C, Holsboer F, Wotjak… Continue reading
Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism.
... treatment with chemically synthesized kalata B1 mutants revealed a region comprising inter-cysteine loops 1 and 2 of the cyclotide framework to be important for biological activity. Cytokine signaling analysis using an ‘active’ kalata B1 mutant [T20K], and the reference… Continue reading
MOR Is Not Enough: Identification of Novel Mu-Opioid Receptor Interacting Proteins Using Traditional and Modified Membrane Yeast Two-Hybrid Screens.
... overdose. HubMed – addiction PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2013 Jul 9; Pfeifer M, Grau M, Lenze D, Wenzel SS, Wolf A,… Continue reading
Inhibitory Action of Quercetin on Eosinophil Activation in Vitro.
... in joint cartilage development, maintenance, and the pathogenesis of joint disease. Methods: We performed the first mouse genetic studies in which the core Notch signaling component, RBPj?, was tissue-specifically deleted within joints. The Prx1Cre transgene removed Rbpj? floxed alleles… Continue reading
Identification of (2-Aminopropyl)indole Positional Isomers in Forensic Samples.
... RAD52-F79 disrupts RAD52 – DNA interaction resulting in accumulation of toxic DNA double stand breaks in malignant cells, but not in normal counterparts. In addition, abrogation of RAD52 – DNA interaction enhanced anti-leukemia effect of the already approved drugs.… Continue reading
Synthesis, Anti-Inflammatory, and Ulcerogenicity Studies of Novel Substituted and Fused Pyrazolo[3,4-d]pyrimidin-4-Ones.
... structure. HubMed – drug Novel Phenotypic Fluorescent Three-Dimensional Platforms for High-throughput Drug Screening and Personalized Chemotherapy. J Cancer. 2013; 4(5): 402-15Fang C, Avis I, Salomon D, Cuttitta F We have developed novel phenotypic fluorescent three-dimensional co-culture platforms that… Continue reading
Safety, Anxiety and Natalizumab Continuation in JC Virus-Seropositive MS Patients.
... dsChi alone caused significant lethal effects, with a mortality four-fold higher than that of the control, whereas feeding with dsTRBP or dsSTAU alone did not yield any significant lethal effects. When dsChi was fed in the mixture 1:1 with… Continue reading