drugs of abuse

The Role of the Aversive Effects of Drugs in Self-Administration: Assessing the Balance of Reward and Aversion in Drug-Taking Behavior.

The role of the aversive effects of drugs in self-administration: assessing the balance of reward and aversion in drug-taking behavior.

Behav Pharmacol. 2013 Jul 16;
Verendeev A, Riley AL

Since the first experimental demonstration that a drug of abuse… Continue reading

[Consensus Regarding the Definition of Persons With Severe Mental Illness and the Number of Such Persons in the Netherlands.]

[Consensus regarding the definition of persons with severe mental illness and the number of such persons in the Netherlands.]

Tijdschr Psychiatr. 2013; 55(6): 427-438
Delespaul P

Insurance companies and mental health service planners need to have information about the… Continue reading

Imaging Addiction: D2 Receptors and Dopamine Signaling in the Striatum as Biomarkers for Impulsivity.

Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity.

Neuropharmacology. 2013 Jul 9;
Trifilieff P, Martinez D

Dependence to drugs of abuse is closely associated with impulsivity, or the propensity to choose a lower,… Continue reading

Expression, Covariation, and Genetic Regulation of miRNA Biogenesis Genes in Brain Supports Their Role in Addiction, Psychiatric Disorders, and Disease.

Expression, covariation, and genetic regulation of miRNA Biogenesis genes in brain supports their role in addiction, psychiatric disorders, and disease.

Front Genet. 2013; 4: 126
Mulligan MK, Dubose C, Yue J, Miles MF, Lu L, Hamre KM

The role… Continue reading

Pharmacokinetics Study of Recombinant Hirudin in the Plasma of Rats Using Chromogenic Substrate, ELISA, and Radioisotope Assays.

Pharmacokinetics study of recombinant hirudin in the plasma of rats using chromogenic substrate, ELISA, and radioisotope assays.

PLoS One. 2013; 8(6): e64336
Jiang SY, Jiao J, Zhang TT, Xu YP

To compare the analytical methods used to study the… Continue reading

Antimicrobial Activity and Probable Mechanisms of Action of Medicinal Plants of Kenya: Withania Somnifera, Warbugia Ugandensis, Prunus Africana and Plectrunthus Barbatus.

Antimicrobial Activity and Probable Mechanisms of Action of Medicinal Plants of Kenya: Withania somnifera, Warbugia ugandensis, Prunus africana and Plectrunthus barbatus.

PLoS One. 2013; 8(6): e65619
Mwitari PG, Ayeka PA, Ondicho J, Matu EN, Bii CC

Withania somnifera, Warbugia… Continue reading

Differential Regulation of the Period Genes in Striatal Regions Following Cocaine Exposure.

Differential Regulation of the Period Genes in Striatal Regions following Cocaine Exposure.

PLoS One. 2013; 8(6): e66438
Falcon E, Ozburn A, Mukherjee S, Roybal K, McClung CA

Several studies have suggested that disruptions in circadian rhythms contribute to the… Continue reading

Prenatal Exposure to Psychostimulants Increases Impulsivity, Compulsivity, and Motivation for Rewards in Adult Mice.

Prenatal exposure to psychostimulants increases impulsivity, compulsivity, and motivation for rewards in adult mice.

Physiol Behav. 2013 Jun 2;
Lloyd SA, Oltean C, Pass H, Phillips B, Staton K, Robertson CL, Shanks RA

Given the widespread use and misuse… Continue reading

Cocaine Tolerance in Honey Bees.

Cocaine tolerance in honey bees.

PLoS One. 2013; 8(5): e64920
Søvik E, Cornish JL, Barron AB

Increasingly invertebrates are being used to investigate the molecular and cellular effects of drugs of abuse to explore basic mechanisms of addiction. However,… Continue reading

Is Your Prescribing Serving a Hidden Addiction?

Is your prescribing serving a hidden addiction?

S Afr Med J. 2013; 103(6): 359-361
Bateman C

Addiction to prescription and over-the-counter (OTC) medicines is a hidden, little-researched chronic illness – which could be significantly countered by destigmatisation, ‘up-scheduling’ certain… Continue reading