drug resistance

Drug-Like Property Profiling of Novel Neuroprotective Compounds to Treat Acute Ischemic Stroke: Guidelines to Develop Pleiotropic Molecules.

Drug-Like Property Profiling of Novel Neuroprotective Compounds to Treat Acute Ischemic Stroke: Guidelines to Develop Pleiotropic Molecules.

Transl Stroke Res. 2013 Jun 1; 4(3): 328-342
Lapchak PA

The development of novel neuroprotective compounds to treat acute ischemic stroke (AIS)… Continue reading

The Antimicrobial Effect of Lactobacillus Casei Culture Supernatant Against Multiple Drug Resistant Clinical Isolates of Shigella Sonnei and Shigella Flexneri in Vitro.

The antimicrobial effect of lactobacillus casei culture supernatant against multiple drug resistant clinical isolates of Shigella sonnei and Shigella flexneri in vitro.

Iran Red Crescent Med J. 2013 Feb; 15(2): 122-6
Mirnejad R, Vahdati AR, Rashidiani J, Erfani M,… Continue reading

Rapid Detection of Human Cytomegalovirus UL97 and UL54 Mutations Directly From Patient Samples.

Rapid Detection of Human Cytomegalovirus UL97 and UL54 Mutations Directly from Patient Samples.

J Clin Microbiol. 2013 May 15;
Sedlak RH, Castor J, Butler-Wu SM, Chan E, Cook L, Limaye AP, Jerome KR

Human cytomegalovirus (CMV) is a significant… Continue reading

HIV Populations Are Large and Accumulate High Genetic Diversity in Nonlinear Fashion.

HIV Populations are Large and Accumulate High Genetic Diversity in Nonlinear Fashion.

J Virol. 2013 May 15;
Maldarelli F, Kearney M, Palmer S, Stephens R, Mican J, Polis MA, Davey RT, Kovacs J, Shao W, Rock-Kress D, Metcalf JA,… Continue reading

Mucosal and Systemic Immune Responses to Mycobacterium Tuberculosis Antigen 85A Following Its Co-Delivery With CpG, MPLA or LTB to the Lungs in Mice.

Mucosal and Systemic Immune Responses to Mycobacterium tuberculosis Antigen 85A following Its Co-Delivery with CpG, MPLA or LTB to the Lungs in Mice.

PLoS One. 2013; 8(5): e63344
Todoroff J, Lemaire MM, Fillee C, Jurion F, Renauld JC, Huygen… Continue reading

Sustained EKR Inhibition by EGFR Targeting Therapies Is a Predictive Factor for Synergistic Cytotoxicity With PDT as Neoadjuvant Therapy.

Sustained EKR inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy.

Biochim Biophys Acta. 2013 Mar; 1830(3): 2659-70
Weyergang A, Selbo PK, Berg K

Tyrosin kinase inhibitors (TKIs) and monoclonal antibodies… Continue reading

Secondary Bacterial Infections of Buruli Ulcer Lesions Before and After Chemotherapy With Streptomycin and Rifampicin.

Secondary bacterial infections of buruli ulcer lesions before and after chemotherapy with streptomycin and rifampicin.

PLoS Negl Trop Dis. 2013 May; 7(5): e2191
Yeboah-Manu D, Kpeli GS, Ruf MT, Asan-Ampah K, Quenin-Fosu K, Owusu-Mireku E, Paintsil A, Lamptey I,… Continue reading

Demonstration of the Innate Electrophilicity of 4-(3-(Benzyloxy)phenyl)-2-(Ethylsulfinyl)-6-(Trifluoromethyl)pyrimidine (BETP), a Small Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 (GLP-1) Receptor.

Demonstration of the Innate Electrophilicity of 4-(3-(Benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a Small Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 (GLP-1) Receptor.

Drug Metab Dispos. 2013 May 7;
Eng H, Sharma R, McDonald TS, Edmonds DJ, Fortin JP, Li X, Stevens… Continue reading

In Vitro Selection of Mutant HDM2 Resistant to Nutlin Inhibition.

In Vitro Selection of Mutant HDM2 Resistant to Nutlin Inhibition.

PLoS One. 2013; 8(4): e62564
Wei SJ, Joseph T, Sim AY, Yurlova L, Zolghadr K, Lane D, Verma C, Ghadessy F

HDM2 binds to the p53 tumour suppressor and… Continue reading

[Antibiotic-Associated Diarrhea in Clinical Practice].

[Antibiotic-associated diarrhea in clinical practice].

Ter Arkh. 2013; 85(2): 85-8

Antibiotic-associated diarrhea (AAD) is considered to mean at least 3 shapeless stool episodes within 2 or more consecutive days when using antibacterial agents. Due to the fact that antibiotics… Continue reading