drug resistance

Effectiveness of the Histone Deacetylase Inhibitor (S)-2 Against LNCaP and PC3 Human Prostate Cancer Cells.

Effectiveness of the Histone Deacetylase Inhibitor (S)-2 against LNCaP and PC3 Human Prostate Cancer Cells.

PLoS One. 2013; 8(3): e58267
Laurenzana A, Balliu M, Cellai C, Romanelli MN, Paoletti F

Histone deacetylase inhibitors (HDACi) represent a promising class of… Continue reading

Hsp90 Inhibitors Exhibit Resistance-Free Antiviral Activity Against Respiratory Syncytial Virus.

Hsp90 Inhibitors Exhibit Resistance-Free Antiviral Activity against Respiratory Syncytial Virus.

PLoS One. 2013; 8(2): e56762
Geller R, Andino R, Frydman J

Respiratory syncytial virus (RSV) is a major cause of respiratory illness in young children, leading to significant morbidity… Continue reading

[Research Progress of Self-Assembled Beads Drug Delivery System Prepared From Cyclodextrins and Oils].

[Research progress of self-assembled beads drug delivery system prepared from cyclodextrins and oils].

Yao Xue Xue Bao. 2012 Dec; 47(12): 1582-6
Liu C, Yi T

Recently, increasing attention has been paid to beads, an innovative self-assembled drug delivery system… Continue reading

[A New Method of Calibration and Positioning in Quantitative Analysis of Multicomponents by Single Marker].

[A new method of calibration and positioning in quantitative analysis of multicomponents by single marker].

Yao Xue Xue Bao. 2012 Dec; 47(12): 1653-9
He B, Yang SY, Zhang Y

This paper aims to establish a new method of calibration… Continue reading

New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cells and Cancer Stem-Like Cells by Some Selected Anthraquinone-Derived Small Molecules.

New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cells and Cancer Stem-Like Cells by Some Selected Anthraquinone-Derived Small Molecules.

PLoS One. 2013; 8(2): e56284
Lee YR, Yu DS, Liang YC, Huang KF, Chou SJ, Chen TC, Lee CC,… Continue reading

Kinetic Modeling-Based Detection of Genetic Signatures That Provide Chemoresistance via the E2F1-p73/DNp73-miR-205 Network.

Kinetic Modeling-Based Detection of Genetic Signatures that Provide Chemoresistance via the E2F1-p73/DNp73-miR-205 Network.

Cancer Res. 2013 Feb 27;
Vera J, Schmitz U, Lai X, Engelmann D, Khan FM, Wolkenhauer O, Putzer BM

Drug resistance is a major cause of… Continue reading

Discovery of Drug Resistance Biomarker Could Improve Cancer Treatment.

Discovery of drug resistance biomarker could improve cancer treatment.

Pharmacogenomics. 2013 Jan; 14(2): 125

HubMed – drug

 

Cognitive Impairment in Multiple Sclerosis: A Forgotten Disability Remembered.

Cerebrum. 2012 11; 2012: 14
Rahn K, Slusher B, Kaplin A… Continue reading

Cover Image, Volume 34, Issue 9.

Cover image, volume 34, issue 9.

J Comput Chem. 2013 Apr 5; 34(9): i-ii

The rapid development of drug resistance in microbes, the toxicity, and side effects of existing anti-infectious drugs are factors stimulating the effort directed toward a… Continue reading

Transcriptional Profiles of the Response of Methicillin-Resistant Staphylococcus Aureus to Pentacyclic Triterpenoids.

Transcriptional Profiles of the Response of Methicillin-Resistant Staphylococcus aureus to Pentacyclic Triterpenoids.

PLoS One. 2013; 8(2): e56687
Chung PY, Chung LY, Navaratnam P

Staphylococcus aureus is an important human pathogen in both hospital and the community that has demonstrated… Continue reading

Gene Expression and Thiopurine Metabolite Profiling in Inflammatory Bowel Disease – Novel Clues to Drug Targets and Disease Mechanisms?

Gene expression and thiopurine metabolite profiling in inflammatory bowel disease – novel clues to drug targets and disease mechanisms?

PLoS One. 2013; 8(2): e56989
Haglund S, Almer S, Peterson C, Söderman J

Thiopurines are effective to induce and maintain remission in inflammatory bowel disease (IBD). The methyl thioinosine monophosphate (meTIMP)/6-thioguanine nucleotide (6-TGN) concentration ratio has been associated with drug efficacy. Here we explored the molecular basis of differences in metabolite profiles and in relation to disease activity.Transcriptional profiles in blood samples from an exploratory IBD-patient cohort (n?=?21) with a normal thiopurine S-methyltransferase phenotype and meTIMP/6-TGN ratios >20, 10.0-14.0 and ?4, respectively, were assessed… Continue reading