drug resistance

How to Optimize Binding of Coated Nanoparticles: Coupling of Physical Interactions, Molecular Organization and Chemical State.

How to Optimize Binding of Coated Nanoparticles: Coupling of Physical Interactions, Molecular Organization and Chemical State.

Biomater Sci. 2013 Aug 1; 1(8): 814-823
Nap RJ, Szleifer I

One of the key challenges in the development of nano carriers for… Continue reading

An Essential Requirement for the Licensing of New Antibiotics Is the Provision of Data on Efficacy and Safety Obtained From Clinical Trials in Which Patients Are Randomized to Receive Either the Experimental Drug or a Comparator Antibiotic Regarded as a Standard Treatment Option. Preface.

An essential requirement for the licensing of new antibiotics is the provision of data on efficacy and safety obtained from clinical trials in which patients are randomized to receive either the experimental drug or a comparator antibiotic regarded as a… Continue reading

Advanced Drug Delivery to the Lymphatic System: Lipid-Based Nanoformulations.

Advanced drug delivery to the lymphatic system: lipid-based nanoformulations.

Int J Nanomedicine. 2013; 8: 2733-44
Khan AA, Mudassir J, Mohtar N, Darwis Y

The delivery of drugs and bioactive compounds via the lymphatic system is complex and dependent on… Continue reading

Pharmacology of Rasagiline, a New MAO-B Inhibitor Drug for the Treatment of Parkinson’s Disease With Neuroprotective Potential.

Pharmacology of Rasagiline, a New MAO-B Inhibitor Drug for the Treatment of Parkinson’s Disease with Neuroprotective Potential.

Rambam Maimonides Med J. 2010 Jul; 1(1): e0003
Finberg JP

Rasagiline (Azilect) is a highly selective and potent propargylamine inhibitor of monoamine… Continue reading

The Antibiotic Susceptibility Patterns of Uropathogenic Escherichia Coli, With Special Reference to the Fluoroquinolones.

The antibiotic susceptibility patterns of uropathogenic Escherichia coli, with special reference to the fluoroquinolones.

J Clin Diagn Res. 2013 Jun; 7(6): 1027-30
Shariff V A AR, Shenoy M S, Yadav T, M R

Context: The emergence of drug resistance… Continue reading

Association Between Ward-Specific Antimicrobial Use Density and Methicillin-Resistant Staphylococcu Aureus Surveillance: A 60-Month Study.

Association between ward-specific antimicrobial use density and methicillin-resistant Staphylococcu aureus surveillance: a 60-month study.

Infect Drug Resist. 2013; 6: 59-66
Yoshida J, Kikuchi T, Matsubara N, Asano I, Ogami N

It is not known whether or not ward-specific antimicrobial… Continue reading

Anthracycline Nano-Delivery Systems to Overcome Multiple Drug Resistance: A Comprehensive Review.

Anthracycline Nano-Delivery Systems to Overcome Multiple Drug Resistance: A Comprehensive Review.

Nano Today. 2013 Jun 1; 8(3): 313-331
Ma P, Mumper RJ

Anthracyclines (doxorubicin, daunorubicin, and idarubicin) are very effective chemotherapeutic drugs to treat many cancers; however, the development… Continue reading

The Pharmacists’ Potential to Provide Targets for Interventions to Optimize Pharmacotherapy in Patients With Asthma.

The pharmacists’ potential to provide targets for interventions to optimize pharmacotherapy in patients with asthma.

Int J Clin Pharm. 2013 Jul 26;
van Boven JF, Hiddink EG, Stuurman-Bieze AG, Schuiling-Veninga CC, Postma MJ, Vegter S

Background Despite of pharmacists’ specialized knowledge of medication and his/her regular contact with patients, the expertise of the pharmacist may not be used enough yet. Furthermore, the potential of pharmacy dispensing data is underestimated. Objective To provide targets for tailored interventions in asthma patients and to illustrate the potential value of pharmacists in the identification of these targets using individual pharmacy dispensing data. Setting We performed a cross sectional retrospective analysis assessing the quality of asthma patients’ pharmacotherapeutic treatment. Method Drug dispensing data from 2008 to 2009 were retrieved from a Dutch pharmacy database. All asthma patients were screened for potential suboptimal pharmacotherapy in 2009. Results were projected to a single community pharmacy to provide an estimate of the number of patients eligible for potential interventions. Main outcome measures (1) frequent use of short-acting ?-agonists without preventive medication, (2) concomitant use of ?-blockers, (3) multiple short courses of oral corticosteroids without using inhaled corticosteroids and 4) use of long-acting ?-agonist without inhaled corticosteroids. Results A total of 8,504 patients were eligible for analysis of the quality of their asthma treatment. 20.9 % of all asthma patients used >100 DDD short-acting ?-agonists… Continue reading

Multidrug-Resistant Tuberculosis in Panama Is Driven by Clonal Expansion of an MDR-TB Strain Related to the KZN XDR-TB Strain From South Africa.

Multidrug-resistant tuberculosis in Panama is driven by clonal expansion of an MDR-TB strain related to the KZN XDR-TB strain from South Africa.

J Clin Microbiol. 2013 Jul 24;
Lanzas F, Karakousis PC, Sacchettini JC, Ioerger TR

Multidrug-resistant tuberculosis (MDR-TB)… Continue reading

Tumor Necrosis Factor Neutralization Combined With Chemotherapy Enhances Mycobacterium Tuberculosis Clearance and Reduces Lung Pathology.

Tumor necrosis factor neutralization combined with chemotherapy enhances Mycobacterium tuberculosis clearance and reduces lung pathology.

Am J Clin Exp Immunol. 2013; 2(1): 124-34
Bourigault ML, Vacher R, Rose S, Olleros ML, Janssens JP, Quesniaux VF, Garcia I

Tuberculosis (TB)… Continue reading