Drug discovery

A New Class of Small Molecule Inhibitor of BMP Signaling.

Published May 7, 2013

A New Class of Small Molecule Inhibitor of BMP Signaling.

PLoS One. 2013; 8(4): e62721
Sanvitale CE, Kerr G, Chaikuad A, Ramel MC, Mohedas AH, Reichert S, Wang Y, Triffitt JT, Cuny GD, Yu PB, Hill CS, Bullock AN… Continue reading →

In Vitro Model Systems to Study Androgen Receptor Signaling in Prostate Cancer.

Published May 7, 2013

In vitro model systems to study androgen receptor signaling in prostate cancer.

Endocr Relat Cancer. 2013 Apr; 20(2): R49-64
Sampson N, Neuwirt H, Puhr M, Klocker H, Eder IE

Prostate cancer (PCa) is one of the most common causes… Continue reading →

In Vitro Antileishmanial, Trypanocidal, and Mammalian Cell Activities of Diverse N,N’ -Dihetaryl Substituted Diamines and Related Compounds.

Published May 5, 2013

In vitro antileishmanial, trypanocidal, and Mammalian cell activities of diverse n,n’ -dihetaryl substituted diamines and related compounds.

Sci Pharm. 2013 Mar; 81(1): 43-55
Leal SM, Amado DF, Kouznetsov VV, Escobar P

The leishmaniasis and Chagas diseases constitute a serious… Continue reading →

Characterization of Rift Valley Fever Virus MP-12 Strain Encoding NSs of Punta Toro Virus or Sandfly Fever Sicilian Virus.

Published May 3, 2013

Characterization of Rift Valley Fever Virus MP-12 Strain Encoding NSs of Punta Toro Virus or Sandfly Fever Sicilian Virus.

PLoS Negl Trop Dis. 2013 Apr; 7(4): e2181
Lihoradova OA, Indran SV, Kalveram B, Lokugamage N, Head JA, Gong B,… Continue reading →

PET Radiopharmaceuticals for Probing Enzymes in the Brain.

Published May 3, 2013

PET radiopharmaceuticals for probing enzymes in the brain.

Am J Nucl Med Mol Imaging. 2013; 3(3): 194-216
Holland JP, Cumming P, Vasdev N

Biologically important processes in normal brain function and brain disease involve the action of various protein-based… Continue reading →

Evaluation of Digoxin Concentration After Loading Dose in Patients With Renal Dysfunction.

Published April 26, 2013

Evaluation of digoxin concentration after loading dose in patients with renal dysfunction.

Can J Hosp Pharm. 2013 Mar; 66(2): 104-9
Pawlosky N, Macdonald E, Patel R, Kanji S

Loading dose recommendations for digoxin are based on the volume of… Continue reading →

Human rElafin Inhibits HIV-1 Replication in Its Natural Target Cells.

Published April 19, 2013

Human rElafin Inhibits HIV-1 Replication in Its Natural Target Cells.

Biores Open Access. 2013 Apr; 2(2): 128-137
Jasinghe VJ, Peyrotte EA, Meyers AF, Gajanayaka N, Ball TB, Sandstrom P, Lavigne C

Trappin-2/elafin is a novel innate immune factor that… Continue reading →

Preparation of Biocompatible Carboxymethyl Chitosan Nanoparticles for Delivery of Antibiotic Drug.

Published April 16, 2013

Preparation of biocompatible carboxymethyl chitosan nanoparticles for delivery of antibiotic drug.

Biomed Res Int. 2013; 2013: 236469
Zhao L, Zhu B, Jia Y, Hou W, Su C

Objective. To prepare biocompatible ciprofloxacin-loaded carboxymethyl chitosan nanoparticles (CCC NPs) and evaluate… Continue reading →

Serious Treatment Related Adverse Drug Reactions Amongst Anti-Retroviral Naïve MDR-TB Patients.

Published April 11, 2013

Serious Treatment Related Adverse Drug Reactions amongst Anti-Retroviral Naïve MDR-TB Patients.

PLoS One. 2013; 8(4): e58817
Van der Walt M, Lancaster J, Odendaal R, Davis JG, Shean K, Farley J

Globally treatment outcomes for multidrug-resistant Mycobacterium tuberculosis (MDR-TB) remain… Continue reading →

Anti-Dermatophytic Activity of Marine Sponge, Sigmadocia Carnosa (Dendy) on Clinically Isolated Fungi.

Published April 10, 2013

Anti-dermatophytic activity of marine sponge, Sigmadocia carnosa (Dendy) on clinically isolated fungi.

Asian Pac J Trop Biomed. 2012 Aug; 2(8): 635-9
Dhayanithi N, Kumar TA, Kalaiselvam M, Balasubramanian T, Sivakumar N

To screen the anti-fungal effects and find out… Continue reading →