Role of Reactive Oxygen Species in the Synergistic Cytotoxicity of Safingol-Based Combination Regimens With Conventional Chemotherapeutics.
Role of reactive oxygen species in the synergistic cytotoxicity of safingol-based combination regimens with conventional chemotherapeutics.
Filed under: Drug and Alcohol Rehabilitation
Oncol Lett. 2011 Sep 1; 2(5): 905-910
Ling LU, Tan KB, Chiu GN
Exploiting the sensitivity of cancer cells to reactive oxygen species (ROS) has been suggested as a strategy for the selective elimination of cancer cells. In this study, the ROS-generating sphingolipid safingol was combined with various conventional chemotherapeutics, and the potential synergism of the safingol-based combination regimen was assessed using a panel of cancer cell lines. The IC(50) values of safingol using as a single agent were 1.4-6.3 µM, which are concentrations that are clinically achievable. While synergism was dependent on the drug molar ratios, a 4:1 molar ratio of safingol to conventional chemotherapeutics exhibited a moderate to strong synergism in MDA-MB-231, JIMT-1, SKOV-3, U937 and KB cells, with combination indices ranging from 0.07 to 0.77. Furthermore, the addition of safingol may reduce the concentrations of conventional chemotherapeutics required to achieve 90% cell-kill by 1 to >3 log-folds. A significant… Continue reading
Drug and Alcohol Rehabilitation: Pharmacology and Anti-Tumor Activity of RWJ67657, a Novel Inhibitor of P38 Mitogen Activated Protein Kinase.
Pharmacology and anti-tumor activity of RWJ67657, a novel inhibitor of p38 mitogen activated protein kinase.
Filed under: Drug and Alcohol Rehabilitation
Am J Cancer Res. 2012; 2(4): 446-58
Antoon JW, Bratton MR, Guillot LM, Wadsworth S, Salvo VA, Elliott… Continue reading
A Potential in Vitro and in Vivo Anti-HIV Drug Screening System for Chinese Herbal Medicines.
A potential in vitro and in vivo anti-HIV drug screening system for Chinese herbal medicines.
Filed under: Drug and Alcohol Rehabilitation
Phytother Res. 2012 Jun; 26(6): 899-907
Feng L, Wang L, Ma YY, Li M, Zhao GQ
Chinese herbal medicines are often applied as an alternative therapy for viral diseases. However, the development of anti-HIV herbal drugs has proceeded slowly, partly because of the lack of a high-throughput system for screening these drugs. The present study evaluated 16 herbal medicines for anti-HIV activities in vitro and in vivo. Herbal medicines were first screened for the ability to regulate C-X-C receptor 4 (CXCR4) and C-C receptor 5 (CCR5) promoter activities. A single-round pseudotyped HIV-luciferase reporter virus system (HIV-Luc) was used to identify potential anti-HIV mechanisms. CD4+ T cells from healthy volunteers were examined for changes in CXCR4 and CCR5 levels. HIV-1 replication was evaluated by ELISA. Spica Prunellae and Herba Andrographitis were found to down-regulate the activities of both the CXCR4 and CCR5 promoters. Also, Spica Prunellae and Herba Andrographitis (>1000 ?M)… Continue reading
Inhibition of Heme Peroxidases by Melamine.
Inhibition of Heme Peroxidases by Melamine.
Filed under: Drug and Alcohol Rehabilitation
Enzyme Res. 2012; 2012: 416062
Vanachayangkul P, Tolleson WH
In 2008 melamine-contaminated infant formula and dairy products in China led to over 50,000 hospitalizations of children due… Continue reading
Confocal Raman Microspectroscopy for Skin Characterization: A Comparative Study Between Human Skin and Pig Skin.
Confocal Raman microspectroscopy for skin characterization: a comparative study between human skin and pig skin.
Filed under: Drug and Alcohol Rehabilitation
Analyst. 2012 Jul 3;
Tfaili S, Gobinet C, Josse G, Angiboust JF, Manfait M, Piot O
The present… Continue reading
Drug and Alcohol Treatment Center: Choosing the Best Residential Drug and Alcohol Treatment Center
There are many treatment centers to choose from. There are many factors that differentiate treatment centers from one another. Can you access it by car or other means? How large is the drug and alcohol treatment center? What… Continue reading
Drug and Alcohol Rehabilitation: Renowned Drug & Alcohol Treatment Center to Host Alumni Reunion – YAHOO!
Renowned Drug & Alcohol Treatment Center to Host Alumni Reunion – YAHOO!
Filed under: Drug and Alcohol Rehabilitation
Burning Tree, a long-term treatment facility in Texas, is inviting alumni back to its Texas ranch to reunite in October. This annual… Continue reading
Patricia Neal’s Awards Displayed at Namesake Rehab Center – Knoxville News Sentinel
Patricia Neal’s awards displayed at namesake rehab center – Knoxville News Sentinel
Filed under: Rehab Centers
On Thursday, Patricia Neal Rehabilitation Center announced it had gotten an award — several, actually. Its namesake, the late actress and Knoxville native Patricia… Continue reading