Confocal Raman Microspectroscopy for Skin Characterization: A Comparative Study Between Human Skin and Pig Skin.

Confocal Raman microspectroscopy for skin characterization: a comparative study between human skin and pig skin.

Filed under: Drug and Alcohol Rehabilitation

Analyst. 2012 Jul 3;
Tfaili S, Gobinet C, Josse G, Angiboust JF, Manfait M, Piot O

The present paper provides a spectral comparison between abdominal human skin (Transkin) and pig ear skin using confocal Raman microspectroscopy at 660 nm. Pig ear skin is usually utilized as a substitute for human skin for active ingredients assessment in dermatological and cosmetics fields. Herein, the comparison is made at the level of the stratum corneum (SC), the SC/epidermis junction and the viable epidermis. The 660 nm excitation source appears to be the most appropriate wavelength for such skin characterization. From Raman signatures of both skin types, a tentative assignment of vibrations was performed in the fingerprint and the high wavenumber spectral regions. Significant differences were highlighted for lipid content in in-depth spectra and for hyaluronic acid (HA) and carotenoid in SC spectra. Marked tissular variability was also revealed by certain Raman vibrations. These intrinsic molecular data probed by confocal Raman microspectroscopy have to be considered for further applications such as cutaneous drug permeation.
HubMed – drug


PURLs: Consider adding this drug to fight COPD that’s severe.

Filed under: Drug and Alcohol Rehabilitation

J Fam Pract. 2012 Jul; 61(7): 414-6
Hobbs K, Brown D

Daily use of azithromycin, in conjunction with the usual COPD regimen, has been found to reduce acute exacerbations in patients with moderate to severe disease.
HubMed – drug


The MicroFlow Spacer: A Drug-Eluting Stent for the Ethmoid Sinus.

Filed under: Drug and Alcohol Rehabilitation

Indian J Otolaryngol Head Neck Surg. 2011 Jul; 63(3): 279-84
Catalano PJ, Thong M, Weiss R, Rimash T

To evaluate the short-term outcomes and safety of a newly introduced drug-eluting ethmoid stent. Prospective study of 23 patients with a total of 40 implanted ethmoid sinuses. Two tertiary care medical facility. Twenty-three patients with medically refractory chronic rhinosinusitis were treated with patient-appropriate endoscopic sinus surgery, with the modification of treating the ethmoid sinuses with an ethmoid stent infused with triamcinolone, instead of conventional endoscopic ethmoidectomy. Patients were then followed up over 6 months. Outcomes were assessed by interval changes in 20-item Sino-Nasal Outcome Test (SNOT-20) and Lund-MacKay CT scores. Safety was determined by adverse events. Overall, the pre-op SNOT-20 mean score was 2.18, versus post-op score of 1.02, an improvement of 1.16 that was both statistically (P < 0.001) and clinically significant. Ethmoid-specific and side-specific Lund-MacKay mean scores both also showed statistically significant improvements. Pre-op ethmoid-specific Lund-MacKay mean score was 1.93, versus post-op score of 1.10, an improvement of 0.83 (P < 0.001). Pre-op side-specific Lund-MacKay mean score was 5.75, compared with post-op score of 2.95, an improvement of 2.80 (P < 0.001). There were no significant intra-op or post-op complications encountered. This triamcinolone-infused ethmoid stent appears safe and effective in treating chronic ethmoid sinus disease within the defined follow-up period. The ability to deliver medication directly to diseased mucosa holds wide-ranging potential. HubMed – drug


Urban bus drivers’ sleep problems and crash accidents.

Filed under: Drug and Alcohol Rehabilitation

Indian J Otolaryngol Head Neck Surg. 2011 Jul; 63(3): 269-73
Razmpa E, Sadegh Niat K, Saedi B

Sleep problems and their direct consequence, sleepiness, results in critical effects on psychomotor skills, memory, decision making, concentration and learning; all of which may play roles in accidents and errors. Despite the importance of quality of sleep among drivers there are only few researches that deal with them. Therefore, we designed this research to better understand possible relationships. This cross-sectional study was performed between 2006 and 2007 among 175 bus drivers of a transportation company in Tehran, the capital of Iran. Participants filled out a questionnaire concerning their demographic and personal history, associated disease, the insomnia index, the Epworth sleepiness scale (ESS), and the apnea index. Then they elaborated their history of crashes. Data was analyzed with the SPSS software through ?(2), Oneway ANOVAs, and Pearson correlation tests. The mean age, and body mass index (BMI) were 43.47 ± 6.85 years and 26.35 ± 3.87 kg/m(2). The mean duration of sleep among these drivers was 6.37 ± 1.62 h per day. The mean accident rate was 2.31 ± 1.83 per year. There was a significant correlation between the insomnia index and BMI (P = 0.014), age (0.00), marital status (0.00), associated disease (0.005), and drug history (0.028). There was a significant relationship between marital status and the ESS, and also between age and accident rate in the past years. Sleep problems were a frequent finding among the studied group and had a significant relationship with their crash history. These results can be an alarming sign to choose bus drivers more carefully and pay more attention to treating their sleep disorders.
HubMed – drug



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The Over Pricing of Drug and Alcohol Treatment

Filed under: Drug and Alcohol Rehabilitation

How could drug treatment centers charge as much as $ 90000 or more per month? The answer is that drug and alcohol treatment is massively overpriced.
Read more on Medical Daily


Palm Partners Announces Launch of YouTube Channel for Addiction Treatment

Filed under: Drug and Alcohol Rehabilitation

Gerard Egan from Palm Partners Recovery Center says of the YouTube Channel launch, “We try to connect with families and patients in a way that goes beyond just the standard treatment for drugs and alcohol. Our addiction treatment programs are designed …
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