Differentiation in the Protein Synthesis-Dependency of Persistent Synaptic Plasticity in Mossy Fiber and Associational/commissural CA3 Synapses in Vivo.
Differentiation in the protein synthesis-dependency of persistent synaptic plasticity in mossy fiber and associational/commissural CA3 synapses in vivo.
Front Integr Neurosci. 2013; 7: 10
Hagena H, Manahan-Vaughan D
Long-term potentiation (LTP) and long-term depression (LTD) are two mechanisms involved in the long-term storage of information in hippocampal synapses. In the hippocampal CA1 region, the late phases of LTP and LTD are protein-synthesis dependent. In the dentate gyrus, late-LTP but not LTD requires protein synthesis. The protein synthesis-dependency of persistent plasticity at CA3 synapses has not yet been characterized. Here, the roles of protein transcription and translation at mossy fiber (mf) and associational/commissural (AC)- synapses were studied in freely behaving rats. In control animals, low-frequency stimulation (LFS) evoked robust LTD (>24 h), whereas high-frequency stimulation (HFS) elicited robust LTP (>24 h) at both mf-CA3 and AC-CA3 synapses. Translation inhibitors prevented early and late phases of LTP and LTD at mf-CA3 synapses. In contrast, at AC-CA3 synapses, translation inhibitors prevented intermediate/late-LTP and late-LTD only. Transcription effects were also synapse-specific: whereas transcription inhibitors inhibited late-LTP and late-LTD (>3 h) at mf-CA3 synapses, at AC-CA3 synapses, protein transcription affected… Continue reading
[Antidepressant Activities of Flavonoids From Glycyrrhiza Uralensis and Its Neurogenesis Protective Effect in Rats].
[Antidepressant activities of flavonoids from Glycyrrhiza uralensis and its neurogenesis protective effect in rats].
Yao Xue Xue Bao. 2012 Dec; 47(12): 1612-7
Fan ZZ, Zhao WH, Guo J, Cheng RF, Zhao JY, Yang WD, Wang YH, Li W, Peng… Continue reading
Vigabatrin Inhibits Seizures and mTOR Pathway Activation in a Mouse Model of Tuberous Sclerosis Complex.
Vigabatrin Inhibits Seizures and mTOR Pathway Activation in a Mouse Model of Tuberous Sclerosis Complex.
PLoS One. 2013; 8(2): e57445
Zhang B, McDaniel SS, Rensing NR, Wong M
Epilepsy is a common neurological disorder and cause of significant morbidity… Continue reading
Internet Cognitive Behavioural Therapy for Mixed Anxiety and Depression: A Randomized Controlled Trial and Evidence of Effectiveness in Primary Care.
Internet cognitive behavioural therapy for mixed anxiety and depression: a randomized controlled trial and evidence of effectiveness in primary care.
Filed under: Depression Treatment
Psychol Med. 2013 Feb 18; 1-14
Newby JM, Mackenzie A, Williams AD, McIntyre K, Watts… Continue reading
Addiction Rehab: Extinction of Conditioned Opiate Withdrawal in Rats Is Blocked by Intracerebroventricular Infusion of an NMDA Receptor Antagonist.
Extinction of conditioned opiate withdrawal in rats is blocked by intracerebroventricular infusion of an NMDA receptor antagonist.
Filed under: Addiction Rehab
Neurosci Lett. 2013 Feb 12;
Coleman BR, Carlezon Jr WA, Myers KM
Maladaptive conditioned responses (CRs) contribute to… Continue reading
Addiction Rehab: Peroxisome Proliferator Activated Receptor-?/Hypoxia Inducible Factor-1? Interplay Sustains Carbonic Anhydrase IX and Apoliprotein E Expression in Breast Cancer Stem Cells.
Peroxisome Proliferator Activated Receptor-?/Hypoxia Inducible Factor-1? Interplay Sustains Carbonic Anhydrase IX and Apoliprotein E Expression in Breast Cancer Stem Cells.
Filed under: Addiction Rehab
PLoS One. 2013; 8(1): e54968
Papi A, Storci G, Guarnieri T, De Carolis S, Bertoni… Continue reading
Depression Treatment: Electrical Impedance of Human Blood With and Without Anticoagulants in the ?-Dispersion Region.
Electrical impedance of human blood with and without anticoagulants in the ?-dispersion region.
Filed under: Depression Treatment
Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012: 3262-4
Simsek FG, Ulgen Y
Impedance spectroscopy of blood with and without… Continue reading